Gene Symbol: ddb2
Description: damage-specific DNA binding protein 2
Alias: si:dkey-45f10.3, DNA damage-binding protein 2
Species: zebrafish

Top Publications

  1. Zeng Z, Richardson J, Verduzco D, Mitchell D, Patton E. Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin. Zebrafish. 2009;6:405-15 pubmed publisher
    ..These studies provide the groundwork for exploring the role of UV light in melanoma development in zebrafish. ..
  2. Gavriouchkina D, Fischer S, Ivacevic T, Stolte J, Benes V, Dekens M. Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. PLoS ONE. 2010;5:e12542 pubmed publisher
    ..These data leads us to propose their involvement in light-induced UV tolerance in the zebrafish embryo. ..
  3. Sandrini J, Trindade G, Nery L, Marins L. Time-course expression of DNA repair-related genes in hepatocytes of zebrafish (Danio rerio) after UV-B exposure. Photochem Photobiol. 2009;85:220-6 pubmed publisher
    ..of the CDKI gene (cyclin-dependent kinase inhibitor) and genes related to DNA damage repair (mainly XPC and DDB2), while the late response observed (24 h) was more related to up-regulation of p53 and genes involved in cell cycle ..
  4. Scrima A, Konícková R, Czyzewski B, Kawasaki Y, Jeffrey P, Groisman R, et al. Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell. 2008;135:1213-23 pubmed publisher
    ..The DDB1-DDB2 complex serves in the initial detection of UV lesions in vivo...
  5. Weger B, Sahinbas M, Otto G, Mracek P, Armant O, Dolle D, et al. The light responsive transcriptome of the zebrafish: function and regulation. PLoS ONE. 2011;6:e17080 pubmed publisher
    ..These findings suggest that the mechanisms involved in period2 regulation might represent a more general pathway leading to light induced gene expression. ..
  6. Glass T, Hui S, Blazar B, Lund T. Effect of radiation dose-rate on hematopoietic cell engraftment in adult zebrafish. PLoS ONE. 2013;8:e73745 pubmed publisher
    ..mortality, cell death in the kidney, endogenous hematopoietic reconstitution, or gene expression levels of p53 and ddb2 (damage-specific DNA binding protein 2) in the kidney...
  7. Ling L, Chang Y, Liu C, Lai P, Hsu T. Oxidative stress intensity-related effects of cadmium (Cd) and paraquat (PQ) on UV-damaged-DNA binding and excision repair activities in zebrafish (Danio rerio) embryos. Chemosphere. 2017;167:10-18 pubmed publisher
    ..Real-time RT-PCR detected a down-regulated xeroderma pigmentosum C (XPC) and an up-regulated UV-DDB2 gene expression in mildly-stressed embryos, whereas 8-oxoguanine DNA glycosylase (OGG1) gene expression increased ..
  8. Chen Q, Li C, Gong Z, Chan E, Snyder S, Lam S. Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 2017;172:429-439 pubmed publisher
    ..The common deregulated genes with the associated biological processes and morphological changes can be used for biological inference of glucocorticoid exposure in fish for future studies. ..
  9. Chang Y, Lee W, Lin Y, Hsu T. Mercury (II) impairs nucleotide excision repair (NER) in zebrafish (Danio rerio) embryos by targeting primarily at the stage of DNA incision. Aquat Toxicol. 2017;192:97-104 pubmed publisher
    ..Our results showed the potential of Hg2+ at environmental relevant levels to disturb NER in zebrafish embryos by targeting primarily at the stage of DNA incision/excision. ..