dbx1b

Summary

Gene Symbol: dbx1b
Description: developing brain homeobox 1b
Alias: hlx2, sb:eu236, homeobox protein DBX1-B, H2.0-like homeobox 2, developing brain homeobox protein 1-B, homeobox protein hlx2
Species: zebrafish

Top Publications

  1. Seo H, Nilsen F, Fjose A. Three structurally and functionally conserved Hlx genes in zebrafish. Biochim Biophys Acta. 1999;1489:323-35 pubmed
    ..0, few members have been identified in vertebrates. In this report, we describe three zebrafish genes, hlx1, hlx2 and hlx3, related to the murine Dbx genes...
  2. Gribble S, Nikolaus O, Dorsky R. Regulation and function of Dbx genes in the zebrafish spinal cord. Dev Dyn. 2007;236:3472-83 pubmed
    ..Our data confirm that the dbx1a/1b/2 domain in zebrafish spinal cord development behaves similarly to amniotes, while extending knowledge of Dbx1 function in spinal cord patterning. ..
  3. Bonner J, Gribble S, Veien E, Nikolaus O, Weidinger G, Dorsky R. Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling. Dev Biol. 2008;313:398-407 pubmed
    ..Together, our work demonstrates that proliferation and patterning in the developing spinal cord are separable events that are regulated independently by Wnt signaling. ..
  4. Guner B, Ozacar A, Thomas J, Karlstrom R. Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis. Endocrinology. 2008;149:4435-51 pubmed publisher
    ..These data suggest that there are distinct origins and signaling requirements for the PD and PI. ..
  5. Wong L, Weadick C, Kuo C, Chang B, Tropepe V. Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. BMC Dev Biol. 2010;10:100 pubmed publisher
  6. Satou C, Kimura Y, Higashijima S. Generation of multiple classes of V0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity. J Neurosci. 2012;32:1771-83 pubmed publisher
    ..These results suggest that multiple types of V0 neurons are produced by two distinct mechanisms; from heterogeneous p0 progenitors and from the same p0 progenitor, but in a time-dependent manner. ..
  7. Juárez Morales J, Schulte C, Pezoa S, Vallejo G, Hilinski W, England S, et al. Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev. 2016;11:5 pubmed publisher
    ..These results significantly increase our understanding of the mechanisms of neuronal specification and the genetic networks involved in these processes. ..
  8. Roberson S, Halpern M. Convergence of signaling pathways underlying habenular formation and axonal outgrowth in zebrafish. Development. 2017;144:2652-2662 pubmed publisher
    ..Time-lapse imaging and fate mapping demonstrate that the dorsal habenulae (dHb) of zebrafish are derived from dbx1b-expressing (dbx1b+ ) progenitors, which transition into cxcr4b-expressing neuronal ..
  9. Koyama M, Kinkhabwala A, Satou C, Higashijima S, FETCHO J. Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain. Proc Natl Acad Sci U S A. 2011;108:1170-5 pubmed publisher
    ..Many different specialized hindbrain networks may arise similarly from a simple early patterning. ..

More Information

Publications14

  1. Kinkhabwala A, Riley M, Koyama M, Monen J, Satou C, Kimura Y, et al. A structural and functional ground plan for neurons in the hindbrain of zebrafish. Proc Natl Acad Sci U S A. 2011;108:1164-9 pubmed publisher
    ..This simple organization probably forms a foundation for the construction of the networks underlying the many behaviors produced by the hindbrain. ..
  2. Wu S, de Borsetti N, Bain E, Bulow C, Gamse J. Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development. Dev Biol. 2014;385:13-22 pubmed publisher
    ..We propose that the Mediator complex is responsible for subtle but significant changes in transcriptional timing and amplitude that are essential for coordinating the development of neurons in the epithalamus. ..
  3. Lee E, Koo Y, Ng A, Wei Y, Luby Phelps K, Juraszek A, et al. Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy. 2014;10:572-87 pubmed publisher
    ..Thus, autophagy plays an essential, conserved role in cardiac morphogenesis during vertebrate development. ..
  4. Dean B, Erdoğan B, Gamse J, Wu S. Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Dev. 2014;9:20 pubmed publisher
    ..Here we examine the expression of a homeodomain transcription factor, dbx1b, and its potential to serve as an early molecular marker of dorsal habenular progenitors...
  5. Lee M, Arrenberg A, Aksay E. A structural and genotypic scaffold underlying temporal integration. J Neurosci. 2015;35:7903-20 pubmed publisher
    ..A second glutamatergic class was more laterally located along a stripe associated with transcription factor dbx1b; these glutamatergic cells had contralateral projections collateralizing near abducens motoneurons, consistent ..