cyt1

Summary

Gene Symbol: cyt1
Description: type I cytokeratin, enveloping layer
Alias: wu:fa03a08, wu:fb34e10, type I cytokeratin, enveloping layer, krtt1c19c
Species: zebrafish
Products:     cyt1

Top Publications

  1. Schaffeld M, H ffling S, Haberkamp M, Conrad M, Markl J. Type I keratin cDNAs from the rainbow trout: independent radiation of keratins in fish. Differentiation. 2002;70:282-91 pubmed publisher
    ..Within this second branch, the teleost keratins form a separate, highly bootstrap-supported twig. This tree leaves little doubt that the teleost Ie keratins diversified independently from the mammalian Ie keratins...
  2. Trede N, Medenbach J, Damianov A, Hung L, Weber G, Paw B, et al. Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc Natl Acad Sci U S A. 2007;104:6608-13 pubmed
    ..Together, our data demonstrate that a mutation in a general splicing factor can lead to distinct defects in organ development and cause disease. ..
  3. Pei W, Noushmehr H, Costa J, Ouspenskaia M, Elkahloun A, Feldman B. An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev Biol. 2007;310:10-22 pubmed
    ..Probing FoxH1 morphant RNA by microarray, we identified a cohort of five keratin genes--cyt1, cyt2, krt4, krt8 and krt18--that are normally transcribed in the embryo's enveloping layer (EVL) and which have ..
  4. Ghosh B, Benyumov A, Ghosh P, Jia Y, Avdulov S, Dahlberg P, et al. Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. ACS Chem Biol. 2009;4:367-77 pubmed publisher
    ..Our work provides strong motivation for the continued development of compounds designed to normalize cap-dependent translation as novel chemo-preventive agents and therapeutics for cancer and fibrosis. ..
  5. Gündel U, Kalkhof S, Zitzkat D, von Bergen M, Altenburger R, Küster E. Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome. Ecotoxicol Environ Saf. 2012;76:11-22 pubmed publisher
    ..Using this experimental design based on testing of several exposure concentrations and less replicates might provide a step forward in getting increased output from toxicoproteomics studies. ..
  6. SAGERSTROM C, Gammill L, Veale R, Sive H. Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants. Dev Dyn. 2005;232:85-97 pubmed
    ..Outer cells, but not deeper cells, are specified to express the EVL-specific marker, cyt1 by late blastula...
  7. Krushna Padhi B, Akimenko M, Ekker M. Independent expansion of the keratin gene family in teleostean fish and mammals: an insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish. Gene. 2006;368:37-45 pubmed
    ..This contrasts with other members of the keratin gene family, which diverged independently between fish and mammals. ..
  8. Fukazawa C, Santiago C, Park K, Deery W, Gomez de la Torre Canny S, Holterhoff C, et al. poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis. Dev Biol. 2010;346:272-83 pubmed publisher
  9. Chen C, Lin D, Cheng C, Lin C, Lo Y, Yen C, et al. Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish. Oncotarget. 2014;5:6300-11 pubmed
    ..Our findings and other characteristics of zebrafish, including optical clarity and small molecule treatment, provide the future utility of this model for easy and non-invasive detection and for identification of new anti-cancer drug. ..

More Information

Publications12

  1. Liu L, Xu Y, Xu L, Wang J, Wu W, Xu L, et al. Analysis of differentially expressed proteins in zebrafish (Danio rerio) embryos exposed to chlorpyrifos. Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:183-9 pubmed
    ..These data may help us understand the functions and the molecular mechanisms of these proteins in zebrafish embryos' response to CPF exposure. ..
  2. Chou C, Chen Y, Su S, Chen G, Huang K, Lien H, et al. Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. J Biomed Sci. 2015;22:102 pubmed publisher
    ..Our data indicate that MEK2 is sufficient to induce epidermal papilloma formation through MAPK signaling in zebrafish, and this transgenic model can be used as a new platform for drug screening. ..
  3. Parolini M, Bini L, Magni S, Rizzo A, Ghilardi A, Landi C, et al. Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environ Pollut. 2018;232:603-614 pubmed publisher
    ..Our data confirmed the potential toxicity of low concentrations of COC, BE and EME, and helped to shed light on their MoA on an aquatic vertebrate during early developmental period. ..