cyp1b1

Summary

Gene Symbol: cyp1b1
Description: cytochrome P450, family 1, subfamily B, polypeptide 1
Alias: CYP1B, zgc:136223, cytochrome P450 1B1, cytochrome P4501B
Species: zebrafish
Products:     cyp1b1

Top Publications

  1. Godard C, Goldstone J, Said M, Dickerson R, Woodin B, Stegeman J. The new vertebrate CYP1C family: cloning of new subfamily members and phylogenetic analysis. Biochem Biophys Res Commun. 2005;331:1016-24 pubmed
    ..Orthologues of CYP1C1 and CYP1C2 were identified in genome databases for other fish species, and both CYP1B1 and CYP1C1 were cloned from zebrafish (Danio rerio)...
  2. Jönsson M, Orrego R, Woodin B, Goldstone J, Stegeman J. Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicol Appl Pharmacol. 2007;221:29-41 pubmed
    ..that the amino acid sequence is 78% identical to CYP1C1, and examined gene structure and expression of CYP1A, CYP1B1, CYP1C1, and CYP1C2. Xenobiotic response elements were observed upstream of the coding regions in all four genes...
  3. Jönsson M, Jenny M, Woodin B, Hahn M, Stegeman J. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2007;100:180-93 pubmed
    ..e., PCNA and cyclin E) in zebra fish (Danio rerio) embryos. Basal and PCB126-induced expression of CYP1A, CYP1B1, CYP1C1, and CYP1C2 was examined over time as well as in relation to cell cycle gene expression and morphological ..
  4. Goldstone J, Goldstone H, Morrison A, Tarrant A, Kern S, Woodin B, et al. Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. Mol Biol Evol. 2007;24:2619-31 pubmed publisher
    Cytochrome P450 family 1 (CYP1) proteins are important in a large number of toxicological processes. CYP1A and CYP1B genes are well known in mammals, but the evolutionary history of the CYP1 family as a whole is obscure; that history may ..
  5. Massarsky A, Bone A, Dong W, Hinton D, Prasad G, Di Giulio R. AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos. Toxicol Appl Pharmacol. 2016;309:63-76 pubmed publisher
    ..were microinjected with nuclear factor erythroid 2-related factor 2 (Nrf2), AHR2, cytochrome P450 1A (CYP1A), or CYP1B1 morpholinos, and deformities were assessed...
  6. Corrales J, Fang X, Thornton C, Mei W, Barbazuk W, Duke M, et al. Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo[a]pyrene exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2014;163:37-46 pubmed publisher
    ..At 96hpf (hours post fertilization) compared to 3.3hpf, dazl, nqo1, sox3, cyp1b1, and gstp1 had higher methylation percentages while c-fos and cdkn1a had decreased CG methylation...
  7. Wincent E, Jönsson M, Bottai M, Lundstedt S, Dreij K. Aryl hydrocarbon receptor activation and developmental toxicity in zebrafish in response to soil extracts containing unsubstituted and oxygenated PAHs. Environ Sci Technol. 2015;49:3869-77 pubmed publisher
    ..In addition to Ahr activating potency, the profile of cytochrome P4501 inhibitors may also determine the toxic potency of the extracts. ..
  8. Knecht A, Goodale B, Truong L, Simonich M, Swanson A, Matzke M, et al. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol Appl Pharmacol. 2013;271:266-75 pubmed publisher
    ..Comprehensive in vivo characterization of 38 structurally diverse OPAHs indicated differential AHR dependency and a prominent role for oxidative stress in the toxicity mechanisms...
  9. Chang C, Chung H, Su H, Tseng H, Tzou W, Hu C. Regulation of zebrafish CYP3A65 transcription by AHR2. Toxicol Appl Pharmacol. 2013;270:174-84 pubmed publisher
    ..It may also reflect the different environments that terrestrial and aquatic organisms encounter. ..

More Information

Publications57

  1. J nsson M, Woodin B, Stegeman J, Brunstr m B. Cytochrome p450 1 genes in birds: evolutionary relationships and transcription profiles in chicken and Japanese quail embryos. PLoS ONE. 2011;6:e28257 pubmed publisher
    ..We cloned cDNAs of chicken CYP1C1 and quail CYP1B1 and AHR1. CYP1Cs occur in several bird genomes, but we found no CYP1C gene in quail...
  2. Lupo G, Gestri G, O Brien M, Denton R, Chandraratna R, Ley S, et al. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proc Natl Acad Sci U S A. 2011;108:8698-703 pubmed publisher
    ..Furthermore, the identification of two cohorts of genes implicated in ventral eye morphogenesis may help to elucidate the genetic basis of ocular coloboma in humans. ..
  3. Sugden W, Leonardo Mendonça R, Acuna Castroviejo D, Siekmann A. Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). PLoS ONE. 2017;12:e0183433 pubmed publisher
    ..We further provide evidence that AHR can regulate the expression of the chemokine receptor cxcr4a in endothelial cells, a regulatory mechanism that may provide insight into AHR function in the endothelium. ..
  4. Yue C, Ji C, Zhang H, Zhang L, Tong J, Jiang Y, et al. Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/?-catenin signal pathways. Environ Toxicol. 2017;32:2316-2322 pubmed publisher
    ..FA supplementation attenuated the EOM-induced upregulation of AhR and its target genes including Cyp1a1, Cyp1b1, Ahrra, and Ahrrb. EROD assay confirmed that the EOM agonized Cyp1a1 activity was diminished by FA...
  5. Zhou Z, Yang J, Chan K. Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquat Toxicol. 2017;191:175-188 pubmed publisher
    ..The impairment of Cyp1a mRNA expression could be due to stimulation by other stressors such as oxidative stress, warranting further investigation into the underlying mechanism in zebrafish. ..
  6. Harskamp J, Britz McKibbin P, Wilson J. Functional screening of cytochrome P450 activity and uncoupling by capillary electrophoresis. Anal Chem. 2012;84:862-6 pubmed publisher
    ..with ?-estradiol confirmed that CYP1A, 1C1, and 1C2 have greater catalytic activity and coupling efficiency; CYP1B1 and 1D1 had coupling efficiencies under 4%...
  7. Šrut M, Bourdineaud J, Štambuk A, Klobučar G. Genomic and gene expression responses to genotoxic stress in PAC2 zebrafish embryonic cell line. J Appl Toxicol. 2015;35:1381-9 pubmed publisher
  8. Godard C, Leaver M, Said M, Dickerson R, George S, Stegeman J. Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba). Mar Environ Res. 2000;50:7-10 pubmed
    ..We report here on the identification and cloning of cytochrome P4501B-like sequences from two teleost fish species and a marine mammal...
  9. Yin H, Tseng H, Chung H, Ko C, Tzou W, Buhler D, et al. Influence of TCDD on zebrafish CYP1B1 transcription during development. Toxicol Sci. 2008;103:158-68 pubmed publisher
    b>Cytochrome P450 1B1 (CYP1B1) is a heme-containing monooxygenase that metabolizes various polycyclic aromatic hydrocarbons and aryl amines, as well as retinoic acid and steroid hormones...
  10. Bräunig J, Schiwy S, Broedel O, Müller Y, Frohme M, Hollert H, et al. Time-dependent expression and activity of cytochrome P450 1s in early life-stages of the zebrafish (Danio rerio). Environ Sci Pollut Res Int. 2015;22:16319-28 pubmed publisher
    ..In the present study, gene expression of cyp1a, cyp1b1, cyp1c1, cyp1c2, and ahr2 as well as EROD activity were investigated up to 120 h postfertilization (hpf) after ..
  11. Timme Laragy A, Noyes P, Buhler D, Di Giulio R. CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). Mar Environ Res. 2008;66:85-7 pubmed publisher
    ..This study tested two hypotheses: (1) in the absence of functional CYP1A, metabolism of PAHs is shunted towards CYP1B1, which has been shown in mammals to produce more reactive metabolites of PAHs; alternatively, (2) CYP1B1 serves a ..
  12. Goodale B, La Du J, Tilton S, Sullivan C, Bisson W, Waters K, et al. Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs. Toxicol Sci. 2015;147:397-411 pubmed publisher
    ..Identifying ligand-dependent AHR interactions and signaling pathways is essential for understanding toxicity of this class of environmentally relevant compounds. ..
  13. Wahl M, Lahni B, Guenther R, Kuch B, Yang L, Straehle U, et al. A technical mixture of 2,2',4,4'-tetrabromo diphenyl ether (BDE47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity. Chemosphere. 2008;73:209-15 pubmed publisher
    ..In addition to the dioxin-like actions, the BDE47 sample enhanced Cyp2B and Cyp3A expression suggesting that commercial PBDE mixtures, which also often contain brominated furans, may disturb cellular homeostasis at multiple levels. ..
  14. Stegeman J, Behrendt L, Woodin B, Kubota A, Lemaire B, Pompon D, et al. Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast. Biochim Biophys Acta. 2015;1850:2340-52 pubmed publisher
    Zebrafish express five cytochrome P450 1 genes: CYP1A, CYP1B1, CYP1C1, CYP1C2, inducible by aryl hydrocarbon receptor agonists, and CYP1D1, a constitutively expressed CYP1A-like gene...
  15. Smith E, Iftikar F, Higgins S, Irshad A, Jandoc R, Lee M, et al. In vitro inhibition of cytochrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes. Aquat Toxicol. 2012;109:259-66 pubmed publisher
    ..Expressed zebrafish CYP1 proteins (CYP1A, CYP1B1, CYP1C1 and CYP1C2) were assessed for inhibition with selected substrates...
  16. Yang J, Zhu J, Chan K. BDE-99, but not BDE-47, is a transient aryl hydrocarbon receptor agonist in zebrafish liver cells. Toxicol Appl Pharmacol. 2016;305:203-215 pubmed publisher
    ..CYP1A induction derived by BDE-99 warrants further risk assessment as the humans, wildlife and environment are exposed to a complex mixture including dioxin-like compounds and carcinogenic compounds. ..
  17. Gao K, Brandt I, Goldstone J, Jönsson M. Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer. Comp Biochem Physiol C Toxicol Pharmacol. 2011;154:42-55 pubmed publisher
    ..The cDNAs of stickleback CYP1A, CYP1B1, CYP1C1, and CYP1C2 were cloned and their basal and induced expression patterns were determined in the brain, gill,..
  18. Scornaienchi M, Thornton C, Willett K, Wilson J. Functional differences in the cytochrome P450 1 family enzymes from zebrafish (Danio rerio) using heterologously expressed proteins. Arch Biochem Biophys. 2010;502:17-22 pubmed publisher
    ..We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP)...
  19. Ko S, Jin H, Jung D, Tian X, Shin I. Cardiosulfa, a small molecule that induces abnormal heart development in zebrafish, and its biological implications. Angew Chem Int Ed Engl. 2009;48:7809-12 pubmed publisher
  20. Xu T, Wang Q, Shi Q, Fang Q, Guo Y, Zhou B. Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish. Environ Toxicol Pharmacol. 2015;40:581-6 pubmed publisher
    ..The mRNA expression of genes related to Phase I and II metabolic enzymes, such as cyp1a1, cyp1b1, cyp1c1 and ugt1ab were also significantly upregulated...
  21. Jia Z, Liu D, Sheng C, Casida J, Wang C, Song P, et al. Acute toxicity, bioconcentration, elimination and antioxidant effects of fluralaner in zebrafish, Danio rerio. Environ Pollut. 2018;232:183-190 pubmed publisher
    ..Among them, the activities of CAT and CarE, and most mRNA expression level of CYPs showed fast response to the sub-lethal concentration of fluralaner, which could be used as a biomarker relevant to the toxicity. ..
  22. Verbueken E, Alsop D, Saad M, Pype C, Van Peer E, Casteleyn C, et al. In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development. Int J Mol Sci. 2017;18: pubmed publisher
    ..Furthermore, Luciferin-IPA was not metabolized by the zebrafish. In conclusion, the capacity of intrinsic biotransformation in zebrafish embryos appears to be lacking during a major part of organogenesis. ..
  23. Williams A, Eason J, Chawla B, Bohnsack B. Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid-Independent Pathway. Invest Ophthalmol Vis Sci. 2017;58:1084-1097 pubmed publisher
    Mutations in the CYP1B1 gene are the most commonly identified genetic causes of primary infantile-onset glaucoma. Despite this disease association, the role of CYP1B1 in eye development and its in vivo substrate remain unknown...
  24. Timme Laragy A, Cockman C, Matson C, Di Giulio R. Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. Aquat Toxicol. 2007;85:241-50 pubmed
    ..Both BNF and ANF each individually resulted in a dose dependent increase CYP1A, CYP1B1, CYP1C1, and AHRR2 mRNA, confirming their activities as AHR agonists...
  25. Bugiak B, Weber L. Hepatic and vascular mRNA expression in adult zebrafish (Danio rerio) following exposure to benzo-a-pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Aquat Toxicol. 2009;95:299-306 pubmed publisher
    ..3 fold-increase, mean+/-SEM respectively). TCDD also increased CYP1A, CYP1B1, CYP1C1, CYP1C2, and COX-1 mRNA expression in mesenteric artery (121+/-23, 5+/-1, 28+/-6, 7+/-1, and 3+/-0...
  26. Behrendt L, Jönsson M, Goldstone J, Stegeman J. Induction of cytochrome P450 1 genes and stress response genes in developing zebrafish exposed to ultraviolet radiation. Aquat Toxicol. 2010;98:74-82 pubmed publisher
    ..93 W/m(2)) for two 3-h or two 4-h pulses (20.1 or 26.8 kJ/m(2)). CYP1B1, SOD1 and PCNA expression was induced by the two 3-h pulses of the higher intensity UVB, but not after two 4-h ..
  27. Goodale B, Tilton S, Corvi M, Wilson G, Janszen D, Anderson K, et al. Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish. Toxicol Appl Pharmacol. 2013;272:656-70 pubmed publisher
    ..These results indicate that systems approaches can be used to classify the toxicity of PAHs based on the networks perturbed following exposure, and may provide a path for unraveling the toxicity of complex PAH mixtures. ..
  28. Ko S, Shin I. Cardiosulfa induces heart deformation in zebrafish through the AhR-mediated, CYP1A-independent pathway. Chembiochem. 2012;13:1483-9 pubmed publisher
    ..Our results indicate that cardiosulfa has potential as a novel type of a biological probe to investigate the AhR pathway. ..
  29. Schiwy S, Bräunig J, Alert H, Hollert H, Keiter S. A novel contact assay for testing aryl hydrocarbon receptor (AhR)-mediated toxicity of chemicals and whole sediments in zebrafish (Danio rerio) embryos. Environ Sci Pollut Res Int. 2015;22:16305-18 pubmed publisher
    ..The highest levels of all investigated cyp genes (cyp1a, cyp1b1, cyp1c1, and cyp1c2) were recorded after exposure to the sediment sample of the Vering canal...
  30. Zhang H, Yao Y, Chen Y, Yue C, Chen J, Tong J, et al. Crosstalk between AhR and wnt/?-catenin signal pathways in the cardiac developmental toxicity of PM2.5 in zebrafish embryos. Toxicology. 2016;355-356:31-8 pubmed publisher
    ..We further found that EOM had increased the expression levels of AhR targeted genes (Cyp1a1, Cyp1b1 and Ahrra) and reduced the mRNA levels of ?-catenin targeted genes (axin2, nkx2.5 and sox9b)...
  31. Jönsson M, Franks D, Woodin B, Jenny M, Garrick R, Behrendt L, et al. The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish. Chem Biol Interact. 2009;181:447-54 pubmed publisher
    ..FICZ binding to two zebrafish AHRs (AHR1B and AHR2) and its ability to induce zebrafish CYP1 genes (CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1) in vivo...
  32. Scornaienchi M, Thornton C, Willett K, Wilson J. Cytochrome P450-mediated 17beta-estradiol metabolism in zebrafish (Danio rerio). J Endocrinol. 2010;206:317-25 pubmed publisher
    ..We have cloned and heterologously expressed CYP1A, CYP1B1, CYP1C1, CYP1C2, CYP1D1, and CYP3A65 from zebrafish (Danio rerio) to determine the CYP-mediated metabolism of E(2) ..
  33. Yang Y, Ji D, Huang X, Zhang J, Liu J. Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish. Environ Toxicol Chem. 2017;36:2139-2146 pubmed publisher
    ..These results suggest that the influence of coexistent metals should be considered in the ecological risk assessment of chiral pyrethroids in aquatic environments. Environ Toxicol Chem 2017;36:2139-2146. © 2017 SETAC. ..
  34. Bugiak B, Weber L. Phenotypic anchoring of gene expression after developmental exposure to aryl hydrocarbon receptor ligands in zebrafish. Aquat Toxicol. 2010;99:423-37 pubmed publisher
    ..However, further experiments are needed to confirm this difference and to determine whether the relationship is causative or merely associative. ..
  35. Truong L, Bugel S, Chlebowski A, Usenko C, Simonich M, Simonich S, et al. Optimizing multi-dimensional high throughput screening using zebrafish. Reprod Toxicol. 2016;65:139-147 pubmed publisher
    ..Adaptation of these better practices for zebrafish HTS should increase reproducibility across laboratories. ..
  36. Van Tiem L, Di Giulio R. AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio). Toxicol Appl Pharmacol. 2011;254:280-7 pubmed publisher
    ..CYP1A, CYP1B1, CYP1C1, and redox-responsive genes glutathione s-transferase pi 2 (GSTp2), glutathione peroxidase 1 (GPx1), the ..
  37. Wirbisky S, Weber G, Sepúlveda M, Lin T, Jannasch A, Freeman J. An embryonic atrazine exposure results in reproductive dysfunction in adult zebrafish and morphological alterations in their offspring. Sci Rep. 2016;6:21337 pubmed publisher
    ..This study provides evidence to support atrazine as an EDC causing reproductive dysfunction and molecular alterations in adults exposed only during embryogenesis and morphological alterations in their offspring. ..
  38. Goodale B, La Du J, Bisson W, Janszen D, Waters K, Tanguay R. AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. PLoS ONE. 2012;7:e29346 pubmed publisher
  39. Du M, Fang C, Qiu L, Dong S, Zhang X, Yan C. Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome P450s in zebrafish (Danio rerio). Chemosphere. 2015;132:24-31 pubmed publisher
    ..and γ-HBCD inhibited cyp1a expression but enhanced the expression of cyp1b1 and cyp1c1...
  40. Garner L, Brown D, Di Giulio R. Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Aquat Toxicol. 2013;142-143:336-46 pubmed publisher
    ..Knockdown of AHR1A did not impact the mRNA expression of CYP1A, CYP1B1, and CYP1C1 in exposed embryos, but it did result in increased CYP1 activity in exposed embryos...
  41. Wincent E, Stegeman J, Jönsson M. Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions. Toxicol Appl Pharmacol. 2015;284:163-79 pubmed publisher
    ..We propose that the AHR has a physiological role in regulating β-catenin during development, and that this is one point of intersection linking toxicological and physiological AHR-governed processes. ..
  42. Chourasia T, Pang Y, Thomas P. The catecholestrogen, 2-hydroxyestradiol-17beta, acts as a G protein-coupled estrogen receptor 1 (GPER/GPR30) antagonist to promote the resumption of meiosis in zebrafish oocytes. Biol Reprod. 2015;92:69 pubmed publisher
    ..The increases in EH activity and OM were blocked by treatment with CYP1A1 and CYP1B1 inhibitors...
  43. Yang Y, Ye X, He B, Liu J. Cadmium potentiates toxicity of cypermethrin in zebrafish. Environ Toxicol Chem. 2016;35:435-45 pubmed publisher
    ..The authors' findings provide a deeper understanding of the mechanistic basis accounting for the joint toxicity of cypermethrin and Cd. ..
  44. Yuan L, Lv B, Zha J, Wang Z, Wang W, Li W, et al. New cytochrome P450 1B1, 1C1, 2Aa, 2Y3, and 2K genes from Chinese rare minnow (Gobiocypris rarus): Molecular characterization, basal expression and response of rare minnow CYP1s and CYP2s mRNA exposed to the AHR agonist benzo[a]pyrene. Chemosphere. 2013;93:209-16 pubmed publisher
    ..The high responsiveness of CYP1 and 2 genes suggested Chinese rare minnow is feasible to screen and assess pollution with AHR agonist. ..
  45. Duan J, Hu H, Zhang Y, Feng L, Shi Y, Miller M, et al. Multi-organ toxicity induced by fine particulate matter PM2.5 in zebrafish (Danio rerio) model. Chemosphere. 2017;180:24-32 pubmed publisher
    ..function (gabrd, chrna3, npy8br) were markedly down-regulated; while genes linked to hepatic metabolism (cyp1a, cyp1b1, cyp1c1) were significantly up-regulated by PM2.5. In summary, our data showed that PM2...
  46. Kühnert A, Vogs C, Seiwert B, Aulhorn S, Altenburger R, Hollert H, et al. Biotransformation in the zebrafish embryo -temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene. Environ Pollut. 2017;230:1-11 pubmed publisher
    ..Time dependent changes in cyp transcription (cyp1a, cyp1b1, cyp1c1 and cyp1c2) as well as concentration & time-dependent courses of BaA in the fish embryo and the ..
  47. Huang L, Zuo Z, Zhang Y, Wu M, Lin J, Wang C. Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity. Chemosphere. 2014;108:55-61 pubmed publisher
    ..Our results were helpful for an understanding of the toxicity of BaP. This study also indicated that microarray analysis was effective for predicting the potential toxicity of chemicals with high sensitivity and accuracy. ..
  48. Xiong K, Peterson R, Heideman W. Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos. Mol Pharmacol. 2008;74:1544-53 pubmed publisher
    ..These results suggest that reduced sox9b expression in TCDD-exposed zebrafish embryos contributes to jaw malformation. ..