Gene Symbol: cygb2
Description: cytoglobin 2
Alias: cygb-2, cytoglobin-2
Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
..There was little change in the expression of the two cytoglobin genes. Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism. ..
Roesner A, Mitz S, Hankeln T, Burmester T. Globins and hypoxia adaptation in the goldfish, Carassius auratus. FEBS J. 2008;275:3633-43 pubmed publisher
Tiedke J, Gerlach F, Mitz S, Hankeln T, Burmester T. Ontogeny of globin expression in zebrafish (Danio rerio). J Comp Physiol B. 2011;181:1011-21 pubmed publisher
..b>Cytoglobin 2 mRNA levels increased gradually, whereas cytoglobin 1 mRNA levels increased strongly after ~31 hpf, which is ..
Fuchs C, Luckhardt A, Gerlach F, Burmester T, Hankeln T. Duplicated cytoglobin genes in teleost fishes. Biochem Biophys Res Commun. 2005;337:216-23 pubmed publisher
..However, Cygb-2 is more than 250-fold stronger expressed in neuronal tissues, suggesting a subfunctionalization of the two cytoglobin paralogs after gene duplication...
Blank M, Burmester T. Widespread occurrence of N-terminal acylation in animal globins and possible origin of respiratory globins from a membrane-bound ancestor. Mol Biol Evol. 2012;29:3553-61 pubmed publisher
Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
..These findings agree with the role of globins in oxidative energy metabolism, but may also hint at a specific function in antioxidative defense. ..
Corti P, Ieraci M, Tejero J. Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins. Nitric Oxide. 2016;53:22-34 pubmed publisher
..We have expressed the recombinant zebrafish proteins Ngb, Cygb1, and Cygb2 in Escherichia coli and characterized their nitrite reduction rates, spectral properties, autoxidation rate ..
Amdahl M, Sparacino Watkins C, Corti P, Gladwin M, Tejero J. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Biochemistry. 2017;56:3993-4004 pubmed publisher
..These data suggest that the cytochrome b5/cytochrome b5 reductase system is a viable reductant for cytoglobin in vivo, allowing for catalytic oxidoreductase activity. ..