Gene Symbol: cybb
Description: cytochrome b-245, beta polypeptide (chronic granulomatous disease)
Alias: zgc:64144, cytochrome b-245, beta polypeptide, gp91, nox2
Brothers K, Newman Z, Wheeler R. Live imaging of disseminated candidiasis in zebrafish reveals role of phagocyte oxidase in limiting filamentous growth. Eukaryot Cell. 2011;10:932-44 pubmed publisher
..The transparent and easily manipulated larval zebrafish model promises to provide a unique tool for dissecting the molecular basis of phagocyte NADPH oxidase-mediated limitation of filamentous growth in vivo...
Yang C, Cambier C, Davis J, Hall C, Crosier P, Ramakrishnan L. Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe. 2012;12:301-12 pubmed publisher
..Our results provide a mechanistic link to the observed patterns of neutrophils in human tuberculous granulomas and the susceptibility of humans with chronic granulomatous disease to mycobacterial infection. ..
Han P, Zhou X, Chang N, Xiao C, Yan S, Ren H, et al
. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Res. 2014;24:1091-107 pubmed publisher
..We conclude that H2O2 potentially generated from Duox/Nox2 promotes heart regeneration in zebrafish by unleashing MAP kinase signaling through a derepression mechanism ..
Weaver C, Leung Y, Suter D. Expression dynamics of NADPH oxidases during early zebrafish development. J Comp Neurol. 2016;524:2130-41 pubmed publisher
..Although the sequences of five NOX genes (nox1, nox2/cybb, nox4, nox5, and duox) have been identified in the zebrafish genome, nothing is known about their expression ..
Jin H, Huang Z, Chi Y, Wu M, Zhou R, Zhao L, et al
. c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 2016;128:415-26 pubmed publisher
..Our study indicates that c-MYB is an intrinsic master regulator for neutrophil terminal differentiation and a potential target in SGD patients. ..
Lu X, Xiang Y, Yang G, Zhang L, Wang H, Zhong S. Transcriptomic characterization of zebrafish larvae in response to mercury exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2017;192:40-49 pubmed publisher
..Thus, these findings provide useful insights to help further understand the transcriptional response and detoxification ability of zebrafish larvae following acute exposure to mercury. ..