cyba

Summary

Gene Symbol: cyba
Description: cytochrome b-245, alpha polypeptide
Alias: zgc:66077, cytochrome b-245, alpha polypeptide, P22phox
Species: zebrafish

Top Publications

  1. Kawahara T, Lambeth J. Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol. 2007;7:178 pubmed
    ..Nox2 forms a heterodimer with the integral membrane protein, p22phox, and this heterodimer binds to the regulatory subunits p47phox, p67phox, p40phox and the small GTPase Rac, ..
  2. Niethammer P, Grabher C, Look A, Mitchison T. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009;459:996-9 pubmed publisher
    ..This is the first observation, to our knowledge, of a tissue-scale H(2)O(2) pattern, and the first evidence that H(2)O(2) signals to leukocytes in tissues, in addition to its known antiseptic role. ..
  3. Yan B, Han P, Pan L, Lu W, Xiong J, Zhang M, et al. IL-1? and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model. J Immunol. 2014;192:5998-6008 pubmed publisher
    ..In addition, Il-1? overexpressing Tg(hsp70:(m)il-1?_eGFP;lyz:DsRed2)hkz10t;nz50 transgenic zebrafish provides a useful animal model for the study of chronic inflammatory disorder and for anti-inflammatory drug discovery. ..
  4. Han P, Zhou X, Chang N, Xiao C, Yan S, Ren H, et al. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Res. 2014;24:1091-107 pubmed publisher
    ..We conclude that H2O2 potentially generated from Duox/Nox2 promotes heart regeneration in zebrafish by unleashing MAP kinase signaling through a derepression mechanism involving Dusp6. ..
  5. Tauzin S, Starnes T, Becker F, Lam P, Huttenlocher A. Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. J Cell Biol. 2014;207:589-98 pubmed publisher
    ..We found that redox-SFK signaling through p22phox and Yes-related kinase is necessary for macrophage wound attraction and the subsequent reverse migration of ..