cxcl18b

Summary

Gene Symbol: cxcl18b
Description: chemokine (C-X-C motif) ligand 18b
Alias: cxcl-c1c, si:ch73-6k14.1, chemokine (C-X-C motif) ligand 18b, CXCL-Clc, chemokine (C-X-C motif) ligand C1c, chemokine CXCL-C1c (LOC795785), cxcl-chr1c, dr-chr25-CXCL11-28.0-EP27297
Species: zebrafish

Top Publications

  1. Stockhammer O, Zakrzewska A, Hegedus Z, Spaink H, Meijer A. Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. J Immunol. 2009;182:5641-53 pubmed publisher
    ..Finally, we showed that induction of il1b, mmp9, and irak3 requires Myd88-dependent signaling, while ifn1 and il8 were induced Myd88 independently during Salmonella infection. ..
  2. Cobbina S, Xu H, Zhao T, Mao G, Zhou Z, Wu X, et al. A multivariate assessment of innate immune-related gene expressions due to exposure to low concentration individual and mixtures of four kinds of heavy metals on zebrafish (Danio rerio) embryos. Fish Shellfish Immunol. 2015;47:1032-42 pubmed publisher
    ..It is indicative that mechanisms associated with toxicity of metal mixtures is complex, however, further studies to elucidate them are ongoing in our research laboratory. ..
  3. Liu Z, Fu Z, Jin Y. Immunotoxic effects of atrazine and its main metabolites at environmental relevant concentrations on larval zebrafish (Danio rerio). Chemosphere. 2017;166:212-220 pubmed publisher
    ..According to these results, both of ATZ and its metabolites exposure could cause the immunotoxicity in larval zebrafish. Thus, we thought that the ecological risks of the metabolites of ATZ on aquatic organisms could not be ignored. ..
  4. Tu W, Niu L, Liu W, Xu C. Embryonic exposure to butachlor in zebrafish (Danio rerio): endocrine disruption, developmental toxicity and immunotoxicity. Ecotoxicol Environ Saf. 2013;89:189-95 pubmed publisher
    ..Bidirectional interactions between the endocrine system and the immune system might be present, and further studies are needed to determine these possible pathways. ..
  5. Jin Y, Chen R, Liu W, Fu Z. Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio). Fish Shellfish Immunol. 2010;28:854-61 pubmed publisher
  6. Wang Y, Wu S, Chen J, Zhang C, Xu Z, Li G, et al. Single and joint toxicity assessment of four currently used pesticides to zebrafish (Danio rerio) using traditional and molecular endpoints. Chemosphere. 2018;192:14-23 pubmed publisher
    ..Taken together, increased toxicity might be triggered by the simultaneous presence of several pesticides in the aquatic environment, which seriously damaged the non-target organisms...
  7. Torraca V, Otto N, Tavakoli Tameh A, Meijer A. The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish. Dev Comp Immunol. 2017;67:57-65 pubmed publisher
    b>Cxcl18b is a chemokine found in zebrafish and in other piscine and amphibian species. Cxcl18b is a reliable inflammatory marker; however, its function is yet to be elucidated...
  8. Xu C, Tu W, Deng M, Jin Y, Lu B, Zhang C, et al. Stereoselective induction of developmental toxicity and immunotoxicity by acetochlor in the early life stage of zebrafish. Chemosphere. 2016;164:618-626 pubmed publisher
  9. Mu X, Chai T, Wang K, Zhang J, Zhu L, Li X, et al. Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages. Aquat Toxicol. 2015;160:57-68 pubmed publisher
    ..At 8 dpe, the modification in the transcription of the tested genes in the embryos and adult fish was similar, except for the genes related to the synthesis of sterols. ..

More Information

Publications23

  1. Xu H, Shao X, Zhang Z, Zou Y, Wu X, Yang L. Oxidative stress and immune related gene expression following exposure to di-n-butyl phthalate and diethyl phthalate in zebrafish embryos. Ecotoxicol Environ Saf. 2013;93:39-44 pubmed publisher
    ..In addition, co-exposure to DBP-DEP also induced antioxidant defense and immune response in zebrafish embryo. The results demonstrat that DBP/DEP exposure could induce the antioxidant and immune responses in zebrafish embryos...
  2. Xu H, Yang M, Qiu W, Pan C, Wu M. The impact of endocrine-disrupting chemicals on oxidative stress and innate immune response in zebrafish embryos. Environ Toxicol Chem. 2013;32:1793-9 pubmed publisher
    ..The authors' results demonstrate that exposure to BPA and NP significantly affects the expression of genes related to immune response in zebrafish embryos following oxidative stress. ..
  3. van der Vaart M, van Soest J, Spaink H, Meijer A. Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system. Dis Model Mech. 2013;6:841-54 pubmed publisher
    ..This zebrafish myd88 mutant will be a valuable tool for further study of the role of IL1R and TLR signaling in the innate immunity processes underlying infectious diseases, inflammatory disorders and cancer...
  4. MarĂ­n Juez R, Jong Raadsen S, Yang S, Spaink H. Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. J Endocrinol. 2014;222:229-41 pubmed publisher
    ..In addition, our data will be very useful in further studies of the function of immunological determinants in a non-obese model system. ..
  5. Zhuang S, Zhang Z, Zhang W, Bao L, Xu C, Zhang H. Enantioselective developmental toxicity and immunotoxicity of pyraclofos toward zebrafish (Danio rerio). Aquat Toxicol. 2015;159:119-26 pubmed publisher
    ..Our in vitro and in silico studies provided a better insight into the molecular basis for aquatic toxicity and thus improved the risk assessment for pyraclofos and other chiral organophosphorus pesticides. ..
  6. Jin Y, Liu Z, Peng T, Fu Z. The toxicity of chlorpyrifos on the early life stage of zebrafish: a survey on the endpoints at development, locomotor behavior, oxidative stress and immunotoxicity. Fish Shellfish Immunol. 2015;43:405-14 pubmed publisher
    ..Taken together, our results suggested that CPF had the potential to cause developmental toxicity, behavior alterations, oxidative stress and immunotoxicity in the larval zebrafish. ..
  7. Yang Y, Qi S, Wang D, Wang K, Zhu L, Chai T, et al. Toxic effects of thifluzamide on zebrafish (Danio rerio). J Hazard Mater. 2016;307:127-36 pubmed publisher
    ..These might be responsible for the adverse expansion of the apoptosis- and immune-related genes, which would facilitate the action of these factors in programmed cell death and might play a key role during the toxic events. ..
  8. Yang L, Zou M, Fu B, He S. Genome-wide identification, characterization, and expression analysis of lineage-specific genes within zebrafish. BMC Genomics. 2013;14:65 pubmed publisher
  9. Torraca V, Tulotta C, Snaar Jagalska B, Meijer A. The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme. Sci Rep. 2017;7:45061 pubmed publisher
    ..Expression of vegfaa was upregulated to a similar extent in cxcr4b mutants and wildtypes, suggesting that the granuloma vascularisation phenotype of cxcr4b mutants is independent of vascular endothelial growth factor. ..
  10. Torraca V, Cui C, Boland R, Bebelman J, van der Sar A, Smit M, et al. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Dis Model Mech. 2015;8:253-69 pubmed publisher
    ..The demonstration of a conserved CXCR3-CXCL11 signaling axis in zebrafish extends the translational applicability of this model for studying diseases involving the innate immune system. ..
  11. Jin Y, Pan X, Cao L, Ma B, Fu Z. Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish Shellfish Immunol. 2013;34:717-23 pubmed publisher
    ..The information presented in this study will help with elucidating the differences and environmental risk of the two enantiomers of cis-BF-induced toxicity in aquatic organisms. ..
  12. Jin Y, Zheng S, Fu Z. Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish Shellfish Immunol. 2011;30:1049-54 pubmed publisher
    ..The information presented in this study will help elucidate the mechanism of CYP-induced toxicity in fish. ..
  13. Yang Y, Liu W, Mu X, Qi S, Fu B, Wang C. Biological response of zebrafish embryos after short-term exposure to thifluzamide. Sci Rep. 2016;6:38485 pubmed publisher
    ..In addition to providing the first description of the mechanism of the toxic effects of thifluzamide on embryos, this study also represents a step towards using embryos to assess mitochondrial metabolism and disease. ..
  14. Feng Y, Santoriello C, Mione M, Hurlstone A, Martin P. Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol. 2010;8:e1000562 pubmed publisher
    ..These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds. ..