Gene Symbol: ctsd
Description: cathepsin D
Alias: catD, wu:fb93e11, wu:fj17b09, cathepsin D, LAP, etID16901.18
Species: zebrafish
Products:     ctsd

Top Publications

  1. Meijer A, Verbeek F, Salas Vidal E, Corredor Adámez M, Bussman J, van der Sar A, et al. Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection. Mol Immunol. 2005;42:1185-203 pubmed
    ..Since a large group of genes linked to immune responses did not show altered expression in the infected animals, these results suggest specific responses in mycobacterium-induced disease. ..
  2. Follo C, Ozzano M, Mugoni V, Castino R, Santoro M, Isidoro C. Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish. PLoS ONE. 2011;6:e21908 pubmed publisher
    The lysosomal aspartic protease Cathepsin D (CD) is ubiquitously expressed in eukaryotic organisms...
  3. Riggio M, Scudiero R, Filosa S, Parisi E. Sex- and tissue-specific expression of aspartic proteinases in Danio rerio (zebrafish). Gene. 2000;260:67-75 pubmed
    ..of the two cDNAs was a 1708 bp product with an open reading frame of 398 amino acid residues corresponding to a cathepsin D. The other was a 1383 bp product encoding a polypeptide chain of 416 amino acids homologous to nothepsin, an ..
  4. Hegedus Z, Zakrzewska A, Agoston V, Ordas A, Racz P, Mink M, et al. Deep sequencing of the zebrafish transcriptome response to mycobacterium infection. Mol Immunol. 2009;46:2918-30 pubmed publisher
  5. De Wit M, Keil D, van der Ven K, Vandamme S, Witters E, De Coen W. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). Gen Comp Endocrinol. 2010;167:190-201 pubmed publisher
    ..Overall, this study demonstrated that a proteomics approach can lift the biological interpretation of microarrays to a higher level, and moreover, opens a window for identification of possible new biomarkers. ..
  6. Che R, Wang R, Xu T. Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker. Fish Shellfish Immunol. 2014;41:163-71 pubmed publisher
  7. Solchenberger B, Russell C, Kremmer E, Haass C, Schmid B. Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology. PLoS ONE. 2015;10:e0118956 pubmed publisher
    ..Loss of zebrafish Grna and Grnb might therefore either be fully compensated or only become symptomatic upon additional challenge. ..
  8. Slade L, Cowie A, Martyniuk C, Kienesberger P, Pulinilkunnil T. Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio). J Pharmacol Exp Ther. 2017;361:375-385 pubmed publisher
    ..Our data demonstrate that dieldrin induces genes associated with cardiovascular dysfunction and compromised lysosomal physiology, thereby identifying a novel mechanism for pesticide-induced cardiotoxicity. ..
  9. Liang P, Jones C, Bisgrove B, Song L, Glenn S, Yost H, et al. Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish. Physiol Genomics. 2004;16:314-22 pubmed publisher

More Information


  1. Eykelbosh A, Van der Kraak G. A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis. Comp Biochem Physiol A Mol Integr Physiol. 2010;156:218-23 pubmed publisher
    ..These results suggest a regulatory role for cathepsin B during follicular apoptosis in zebrafish ovarian follicles. ..
  2. Follo C, Ozzano M, Montalenti C, Santoro M, Isidoro C. Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy. Biosci Rep. 2013;33:e00034 pubmed publisher
    CD (cathepsin D) is a ubiquitous lysosomal hydrolase involved in a variety of pathophysiological functions, including protein turnover, activation of pro-hormones, cell death and embryo development...
  3. Pfefferli C, Muller F, Jazwinska A, Wicky C. Specific NuRD components are required for fin regeneration in zebrafish. BMC Biol. 2014;12:30 pubmed publisher
    ..These results provide in vivo evidence for the involvement of key epigenetic factors in the cellular reprogramming processes occurring during epimorphic regeneration in zebrafish. ..
  4. Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, et al. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017;26:2335-2345 pubmed publisher
    ..We conclude that CERKL deficiency in zebrafish may cause rod-cone dystrophy, but not cone-rod dystrophy, while interfering with the phagocytosis function of RPE associated with down-regulation of the expression of MERTK. ..
  5. Riggio M, Scudiero R, Filosa S, Parisi E. Oestrogen-induced expression of a novel liver-specific aspartic proteinase in Danio rerio (zebrafish). Gene. 2002;295:241-6 pubmed
    ..They include related paralogous proteins such as cathepsin D, cathepsin E and pepsin...