Gene Symbol: ctrb1
Description: chymotrypsinogen B1
Alias: wu:fb61f07, wu:fb69e12, chymotrypsin B1, fb69e12
Wang H, Zhou Q, Kesinger J, Norris C, Valdez C. Heme regulates exocrine peptidase precursor genes in zebrafish. Exp Biol Med (Maywood). 2007;232:1170-80 pubmed
..Our findings provide a better understanding of heme deficiency pathogenesis and enhance our ability to diagnose and treat patients with porphyria or pancreatic diseases. ..
Sant K, Jacobs H, Borofski K, Moss J, Timme Laragy A. Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio. Environ Pollut. 2017;220:807-817 pubmed publisher
Trede N, Medenbach J, Damianov A, Hung L, Weber G, Paw B, et al
. Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc Natl Acad Sci U S A. 2007;104:6608-13 pubmed
..Together, our data demonstrate that a mutation in a general splicing factor can lead to distinct defects in organ development and cause disease. ..
Zhang S, Xu M, Huang J, Tang L, Zhang Y, Wu J, et al
. Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish. Dis Model Mech. 2014;7:837-45 pubmed publisher
..These results provide novel insights into the regulation of exocrine function, as well as the pathogenesis of porphyria, and should be useful for designing new therapies for both types of disease. ..
Mesquita S, van Drooge B, Oliveira E, Grimalt J, Barata C, Vieira N, et al
. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environ Pollut. 2015;206:535-42 pubmed publisher
..The observed effects can be directly related to air pollution-related human disorders, suggesting different potential adverse outcomes for human populations exposed to air pollution from specific sources. ..
Mesquita S, Dachs J, van Drooge B, Castro JimÃ©nez J, Navarro MartÃn L, Barata C, et al
. Toxicity assessment of atmospheric particulate matter in the Mediterranean and Black Seas open waters. Sci Total Environ. 2016;545-546:163-70 pubmed publisher
..The present study emphasizes the need for more in-depth studies into the toxic burden of atmospheric PM on aquatic ecosystems, in order to improve future regulatory guidelines. ..
Hostelley T, Lodh S, Zaghloul N. Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes. BMC Genomics. 2016;17:318 pubmed publisher
..These findings provide important novel insight into shared and divergent phenotypes between two similar but distinct genetic syndromes. ..
Mesquita S, van Drooge B, Dall Osto M, Grimalt J, Barata C, Vieira N, et al
. Toxic potential of organic constituents of submicron particulate matter (PM1) in an urban road site (Barcelona). Environ Sci Pollut Res Int. 2017;24:15406-15415 pubmed publisher
..Our data suggest that the toxic potential of PM1 organic chemical constituents strongly depends on the emission sources and on the process of ageing from primary to secondary organic aerosols. ..