csf3r

Summary

Gene Symbol: csf3r
Description: colony stimulating factor 3 receptor (granulocyte)
Alias: gcsfr, granulocyte colony-stimulating factor receptor, granulocyte stimulating factor receptor
Species: zebrafish

Top Publications

  1. Liongue C, Hall C, O Connell B, Crosier P, Ward A. Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration. Blood. 2009;113:2535-46 pubmed publisher
    Granulocyte colony-stimulating factor receptor (GCSFR) signaling participates in the production of neutrophilic granulocytes during normal hematopoietic development, with a particularly important role during emergency hematopoiesis...
  2. Balla K, Lugo Villarino G, Spitsbergen J, Stachura D, Hu Y, Banuelos K, et al. Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 2010;116:3944-54 pubmed publisher
  3. Lewis R, Noor S, Fraser F, Sertori R, Liongue C, Ward A. Regulation of embryonic hematopoiesis by a cytokine-inducible SH2 domain homolog in zebrafish. J Immunol. 2014;192:5739-48 pubmed publisher
    ..This occurred concomitantly with increased activation of STAT5. This study indicates that CISH functions as a conserved in vivo target and regulator of STAT5 in the control of embryonic hematopoiesis. ..
  4. Lu X, Li X, He Q, Gao J, Gao Y, Liu B, et al. miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Res. 2013;23:1356-68 pubmed publisher
    ..Together, these findings unveil the pivotal roles that miR-142a-3p plays in the formation and differentiation of HSCs by repressing irf7 signaling...
  5. Stachura D, Svoboda O, Campbell C, Espin Palazon R, Lau R, Zon L, et al. The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013;122:3918-28 pubmed publisher
    ..These findings may inform how hematopoietic cytokines evolved following the diversification of teleosts and mammals from a common ancestor...
  6. Hall C, Flores M, Oehlers S, Sanderson L, Lam E, Crosier K, et al. Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide. Cell Stem Cell. 2012;10:198-209 pubmed publisher
    ..These results provide new insights into the reactive capacity of HSPCs and how the blood system is "fine-tuned" in response to inflammatory stress. ..
  7. Feng Y, RENSHAW S, Martin P. Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE?. Curr Biol. 2012;22:1253-9 pubmed publisher
    ..Our in vivo observations at these early stages of cancer initiation provide a potential mechanistic explanation for why long-term use of low doses of NSAIDs, including aspirin, might reduce cancer onset. ..
  8. Stachura D, Svoboda O, Lau R, Balla K, Zon L, Bartunek P, et al. Clonal analysis of hematopoietic progenitor cells in the zebrafish. Blood. 2011;118:1274-82 pubmed publisher
  9. Wittamer V, Bertrand J, Gutschow P, Traver D. Characterization of the mononuclear phagocyte system in zebrafish. Blood. 2011;117:7126-35 pubmed publisher
    ..These findings suggest that mhc2dab:GFP and cd45:DsRed transgenic lines will be instrumental in elucidating the immune response in the zebrafish. ..

More Information

Publications17

  1. Alcaraz Pérez F, García Castillo J, García Moreno D, López Muñoz A, Anchelin M, Angosto D, et al. A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nat Commun. 2014;5:3228 pubmed publisher
    ..The alteration in spi1 and gata1 levels occurs through stimulation of gcsf and mcsf. Our model of TR deficiency in the zebrafish illuminates the non-canonical roles of TR, and could establish therapeutic targets for DC. ..
  2. Ellett F, Pase L, Hayman J, Andrianopoulos A, Lieschke G. mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish. Blood. 2011;117:e49-56 pubmed publisher
    ..These zebrafish transgenes provide a new resource that will contribute to the fields of inflammation, infection, and leukocyte biology. ..
  3. Svoboda O, Stachura D, Machonova O, Pajer P, Brynda J, Zon L, et al. Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014;124:220-8 pubmed publisher
  4. He Q, Zhang C, Wang L, Zhang P, Ma D, Lv J, et al. Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 2015;125:1098-106 pubmed publisher
    ..Our findings establish a previously unrecognized link between inflammatory signaling and HSPC emergence, and provide new insights into regenerative medicine and novel therapies to treat innate immune-related diseases. ..
  5. Wang S, He Q, Ma D, Xue Y, Liu F. Irf4 Regulates the Choice between T Lymphoid-Primed Progenitor and Myeloid Lineage Fates during Embryogenesis. Dev Cell. 2015;34:621-31 pubmed publisher
    ..1 expression to prevent an alternate fate. Our findings provide insight into the fate determination mechanism of T lymphoid-primed progenitors. ..
  6. Svoboda O, Stachura D, Machonova O, Zon L, Traver D, Bartunek P. Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nat Protoc. 2016;11:1007-20 pubmed publisher
    ..The present protocol should facilitate such studies on cells derived from zebrafish. ..
  7. Pazhakh V, Clark S, Keightley M, Lieschke G. A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia. Sci Rep. 2017;7:44455 pubmed publisher
    Granulocyte colony-stimulating factor (GCSF) and its receptor (GCSFR), also known as CSF3 and CSF3R, are required to maintain normal neutrophil numbers during basal and emergency granulopoiesis in humans, mice and zebrafish...
  8. Yuan H, Zhou J, Deng M, Zhang Y, Chen Y, Jin Y, et al. Sumoylation of CCAAT/enhancer-binding protein ? promotes the biased primitive hematopoiesis of zebrafish. Blood. 2011;117:7014-20 pubmed publisher
    ..Our results therefore implicate sumoylation in early lineage determination and reveal the possible molecular mechanism underlying the puzzling biased primitive hematopoiesis in vertebrates. ..