Gene Symbol: cryaba
Description: crystallin, alpha B, a
Alias: cryab, alpha-crystallin B chain, hspb5, hspb5a
Species: zebrafish
Products:     cryaba

Top Publications

  1. Dahlman J, Margot K, Ding L, Horwitz J, Posner M. Zebrafish alpha-crystallins: protein structure and chaperone-like activity compared to their mammalian orthologs. Mol Vis. 2005;11:88-96 pubmed
    ..Future comparative studies of alpha-crystallin from closely related vertebrate species can help identify specific structural changes that lead to alterations in chaperone-like activity. ..
  2. Smith A, Wyatt K, Vacha J, Vihtelic T, Zigler J, Wistow G, et al. Gene duplication and separation of functions in alphaB-crystallin from zebrafish (Danio rerio). FEBS J. 2006;273:481-90 pubmed
    ..Gene duplication may have allowed these functions to separate, providing a unique model for studying structure-function relationships and the regulation of tissue-specific expression patterns. ..
  3. Harding R, Howley S, Baker L, Murphy T, Archer W, Wistow G, et al. Lengsin expression and function during zebrafish lens formation. Exp Eye Res. 2008;86:807-18 pubmed publisher
    ..These results demonstrate Lengsin is required for proper fiber cell differentiation by playing roles in either cell elongation or the establishment of cell interactions. ..
  4. Marvin M, O Rourke D, Kurihara T, Juliano C, Harrison K, Hutson L. Developmental expression patterns of the zebrafish small heat shock proteins. Dev Dyn. 2008;237:454-63 pubmed
    ..The results of these studies provide a foundation for analysis of sHSP function during normal development and their roles in protecting cells from the effects environmental stressors. ..
  5. Bührdel J, Hirth S, Kessler M, Westphal S, Forster M, Manta L, et al. In vivo characterization of human myofibrillar myopathy genes in zebrafish. Biochem Biophys Res Commun. 2015;461:217-23 pubmed publisher
    ..In summary, our results indicate that the zebrafish is a suitable model to functionally and structurally evaluate novel MFM disease genes in vivo. ..
  6. Koteiche H, Claxton D, Mishra S, Stein R, McDonald E, McHaourab H. Species-Specific Structural and Functional Divergence of α-Crystallins: Zebrafish αBa- and Rodent αA(ins)-Crystallin Encode Activated Chaperones. Biochemistry. 2015;54:5949-58 pubmed publisher
    ..These results emphasize the role of sequence divergence as an evolutionary strategy to tune chaperone function to the requirements of the tissues and organisms in which they are expressed. ..
  7. Franck E, Madsen O, van Rheede T, Ricard G, Huynen M, de Jong W. Evolutionary diversity of vertebrate small heat shock proteins. J Mol Evol. 2004;59:792-805 pubmed
    ..Interesting is the occurrence of several head-to-head located pairs of chordate sHsp genes. ..
  8. Zou P, Wu S, Koteiche H, Mishra S, Levic D, KNAPIK E, et al. A conserved role of αA-crystallin in the development of the zebrafish embryonic lens. Exp Eye Res. 2015;138:104-13 pubmed publisher
  9. Posner M, Murray K, McDonald M, Eighinger H, Andrew B, Drossman A, et al. The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function. Peerj. 2017;5:e4093 pubmed publisher

More Information


  1. Wages P, Horwitz J, Ding L, Corbin R, Posner M. Changes in zebrafish (Danio rerio) lens crystallin content during development. Mol Vis. 2013;19:408-17 pubmed
    ..Similarities with mammalian crystallin expression continue to support the use of the zebrafish as a model for lens crystallin function. ..
  2. Mishra S, Wu S, Fuller A, Wang Z, Rose K, Schey K, et al. Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart. J Biol Chem. 2018;293:740-753 pubmed publisher
  3. Mao L, Shelden E. Developmentally regulated gene expression of the small heat shock protein Hsp27 in zebrafish embryos. Gene Expr Patterns. 2006;6:127-33 pubmed
    ..Here, we assessed the temporospatial dynamics of zebrafish Hsp27 (hsp27) and alpha-B crystallin (cryab) gene expression using reverse-transcriptase PCR (RT-PCR) and hsp27 expression by in situ hybridization...
  4. Elicker K, Hutson L. Genome-wide analysis and expression profiling of the small heat shock proteins in zebrafish. Gene. 2007;403:60-9 pubmed of a number of sHSPs, including HSP27 (HSPB1), HSP22 (HSPB8), alphaA-crystallin (HSPB4), or alphaB-crystallin (HSPB5) can result in neuronal degeneration, myopathy, and/or cataract in humans...