cry5

Summary

Gene Symbol: cry5
Description: cryptochrome circadian clock 5
Alias: z6-4phr, z64phr, cryptochrome circadian clock 5, 6-4 photolyase, cry5/6-4phr, cryptochrome 5
Species: zebrafish

Top Publications

  1. Hirayama J, Miyamura N, Uchida Y, Asaoka Y, Honda R, Sawanobori K, et al. Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell Cycle. 2009;8:2794-801 pubmed
    ..that light-induced activation of these pathways controls the expression of two evolutionary-related genes, z64Phr and zCry1a, revealing that light-dependent DNA repair and the entrainment of circadian clock share common ..
  2. Kobayashi Y, Ishikawa T, Hirayama J, Daiyasu H, Kanai S, Toh H, et al. Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish. Genes Cells. 2000;5:725-38 pubmed
    ..The expressions of these cry genes oscillate in a circadian manner, but their patterns differ. These findings suggest that functionally diverse cry genes are present in zebrafish and each gene has different role in the molecular clock. ..
  3. Tamai T, Vardhanabhuti V, Foulkes N, Whitmore D. Early embryonic light detection improves survival. Curr Biol. 2004;14:R104-5 pubmed
  4. Gavriouchkina D, Fischer S, Ivacevic T, Stolte J, Benes V, Dekens M. Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. PLoS ONE. 2010;5:e12542 pubmed publisher
    ..These data leads us to propose their involvement in light-induced UV tolerance in the zebrafish embryo. ..
  5. Weger B, Sahinbas M, Otto G, Mracek P, Armant O, Dolle D, et al. The light responsive transcriptome of the zebrafish: function and regulation. PLoS ONE. 2011;6:e17080 pubmed publisher
    ..These findings suggest that the mechanisms involved in period2 regulation might represent a more general pathway leading to light induced gene expression. ..
  6. Huang L, Zuo Z, Zhang Y, Wu M, Lin J, Wang C. Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity. Chemosphere. 2014;108:55-61 pubmed publisher
    ..Our results were helpful for an understanding of the toxicity of BaP. This study also indicated that microarray analysis was effective for predicting the potential toxicity of chemicals with high sensitivity and accuracy. ..
  7. Faltermann S, Hutter S, Christen V, Hettich T, Fent K. Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio). Toxins (Basel). 2016;8: pubmed publisher
    ..The data further demonstrate that pathways that are influenced by microcystin-LR are not affected by aeruginosin 828A. ..
  8. Oggier D, Lenard A, Kury M, Hoeger B, Affolter M, Fent K. Effects of the protein kinase inhibitor PKC412 on gene expression and link to physiological effects in zebrafish Danio rerio eleuthero-embryos. Toxicol Sci. 2011;119:104-15 pubmed publisher
    ..This study leads to the conclusion that PKC412-induced alterations of gene transcripts are partly paralleled by physiological effects at high, but not at low PKC412 concentrations expected to be of environmental relevance. ..
  9. Lu X, Xiang Y, Yang G, Zhang L, Wang H, Zhong S. Transcriptomic characterization of zebrafish larvae in response to mercury exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2017;192:40-49 pubmed publisher
    ..Thus, these findings provide useful insights to help further understand the transcriptional response and detoxification ability of zebrafish larvae following acute exposure to mercury. ..

More Information

Publications15

  1. Oggier D, Weisbrod C, Stoller A, Zenker A, Fent K. Effects of diazepam on gene expression and link to physiological effects in different life stages in zebrafish Danio rerio. Environ Sci Technol. 2010;44:7685-91 pubmed publisher
  2. Mracek P, Santoriello C, Idda M, Pagano C, Ben Moshe Z, Gothilf Y, et al. Regulation of per and cry genes reveals a central role for the D-box enhancer in light-dependent gene expression. PLoS ONE. 2012;7:e51278 pubmed publisher
    ..Given the existence of different photoreceptors in fish cells, our results implicate the D-box enhancer as a general convergence point for light driven signaling. ..
  3. Mracek P, Pagano C, Fröhlich N, Idda M, Cuesta I, López Olmeda J, et al. ERK Signaling Regulates Light-Induced Gene Expression via D-Box Enhancers in a Differential, Wavelength-Dependent Manner. PLoS ONE. 2013;8:e67858 pubmed publisher
    ..Thus, we reveal that D-box-driven gene expression is regulated via ERK/MAPK signaling in a strongly wavelength-dependent manner. ..
  4. Faltermann S, Zucchi S, Kohler E, Blom J, Pernthaler J, Fent K. Molecular effects of the cyanobacterial toxin cyanopeptolin (CP1020) occurring in algal blooms: global transcriptome analysis in zebrafish embryos. Aquat Toxicol. 2014;149:33-9 pubmed publisher
  5. Zucchi S, Mirbahai L, Castiglioni S, Fent K. Transcriptional and physiological responses induced by binary mixtures of drospirenone and progesterone in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:3523-31 pubmed publisher
    ..Effects of DRS and P4 were additive for most of the investigated parameters and occurred at environmentally relevant concentrations. They may translate to adverse reproductive effects in fish. ..
  6. Osaki T, Uchida Y, Hirayama J, Nishina H. Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol Pharm Bull. 2011;34:1343-7 pubmed
    ..Our findings also support the existence of a regulatory link between photoreactivation and the circadian clock in this species. ..