Gene Symbol: cry1bb
Description: cryptochrome circadian clock 1bb
Alias: cry2b, zcry2b, cryptochrome 2b, cry3b
Species: zebrafish

Top Publications

  1. Ishikawa T, Hirayama J, Kobayashi Y, Todo T. Zebrafish CRY represses transcription mediated by CLOCK-BMAL heterodimer without inhibiting its binding to DNA. Genes Cells. 2002;7:1073-86 pubmed
    ..Our findings suggest that CRY represses CLOCK-BMAL-mediated transcription by interacting directly with the zfCLOCK-zfBMAL-E-box complex. ..
  2. Kobayashi Y, Ishikawa T, Hirayama J, Daiyasu H, Kanai S, Toh H, et al. Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish. Genes Cells. 2000;5:725-38 pubmed
    ..The expressions of these cry genes oscillate in a circadian manner, but their patterns differ. These findings suggest that functionally diverse cry genes are present in zebrafish and each gene has different role in the molecular clock. ..
  3. Liu C, Hu J, Qu C, Wang L, Huang G, Niu P, et al. Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Sci Rep. 2015;5:8113 pubmed publisher
    ..retained six cry genes, renamed as cry1aa (zcry1a in the old nomenclature), cry1ab (zcry1b), cry1ba (zcry2a), cry1bb (zcry2b), cry2 (zcry3) and cry3 (zcry4)...
  4. Cruz B, Brongar L, Popiolek P, Gonçalvez B, Figueiredo M, Amaral I, et al. Clock genes expression and locomotor activity are altered along the light-dark cycle in transgenic zebrafish overexpressing growth hormone. Transgenic Res. 2017;26:739-752 pubmed publisher
    ..Furthermore, although no differences were observed between NT and GH animals for bmal1a and cry2b expression at each time point, only GH fish presented amplitude along the LD cycle...
  5. Gavriouchkina D, Fischer S, Ivacevic T, Stolte J, Benes V, Dekens M. Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. PLoS ONE. 2010;5:e12542 pubmed publisher
    ..These data leads us to propose their involvement in light-induced UV tolerance in the zebrafish embryo. ..
  6. Wang M, Zhong Z, Zhong Y, Zhang W, Wang H. The zebrafish period2 protein positively regulates the circadian clock through mediation of retinoic acid receptor (RAR)-related orphan receptor α (Rorα). J Biol Chem. 2015;290:4367-82 pubmed publisher
    ..delay under constant darkness, and quantitative real time PCR analyses showed up-regulation of cry1aa, cry1ba, cry1bb, and aanat2 but down-regulation of per1b, per3, and bmal1b in per2 mutant zebrafish, suggesting that Per2 is ..
  7. Chen Q, Li C, Gong Z, Chan E, Snyder S, Lam S. Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 2017;172:429-439 pubmed publisher
    ..Three genes (cry2b, fbxo32, and klhl38b) responded robustly to all glucocorticoid concentrations tested...
  8. Zhao Y, Zhang K, Fent K. Regulation of zebrafish (Danio rerio) locomotor behavior and circadian rhythm network by environmental steroid hormones. Environ Pollut. 2018;232:422-429 pubmed publisher
    ..Our results suggest that steroid hormones can modulate the circadian molecular network in zebrafish and provide novel insights into their mode of actions and potential environmental risks. ..
  9. Oggier D, Weisbrod C, Stoller A, Zenker A, Fent K. Effects of diazepam on gene expression and link to physiological effects in different life stages in zebrafish Danio rerio. Environ Sci Technol. 2010;44:7685-91 pubmed publisher

More Information


  1. Amaral I, Johnston I. Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish. Am J Physiol Regul Integr Comp Physiol. 2012;302:R193-206 pubmed publisher
    ..The role of circadian clocks in regulating muscle maintenance and growth are discussed. ..