Gene Symbol: cry1ba
Description: cryptochrome circadian clock 1ba
Alias: cry2a, zgc:110521, cryptochrome-1, cry3a, cryptochrome 2a
Species: zebrafish

Top Publications

  1. Gavriouchkina D, Fischer S, Ivacevic T, Stolte J, Benes V, Dekens M. Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. PLoS ONE. 2010;5:e12542 pubmed publisher
    ..These data leads us to propose their involvement in light-induced UV tolerance in the zebrafish embryo. ..
  2. Kobayashi Y, Ishikawa T, Hirayama J, Daiyasu H, Kanai S, Toh H, et al. Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish. Genes Cells. 2000;5:725-38 pubmed
    ..The expressions of these cry genes oscillate in a circadian manner, but their patterns differ. These findings suggest that functionally diverse cry genes are present in zebrafish and each gene has different role in the molecular clock. ..
  3. Cahill G. Clock mechanisms in zebrafish. Cell Tissue Res. 2002;309:27-34 pubmed
    ..The interactions of clock gene products are for the most part similar to their interactions in mammals, although there are some potentially interesting differences. ..
  4. Wang M, Zhong Z, Zhong Y, Zhang W, Wang H. The zebrafish period2 protein positively regulates the circadian clock through mediation of retinoic acid receptor (RAR)-related orphan receptor α (Rorα). J Biol Chem. 2015;290:4367-82 pubmed publisher
    ..2-h phase delay under constant darkness, and quantitative real time PCR analyses showed up-regulation of cry1aa, cry1ba, cry1bb, and aanat2 but down-regulation of per1b, per3, and bmal1b in per2 mutant zebrafish, suggesting that Per2 ..
  5. Liu C, Hu J, Qu C, Wang L, Huang G, Niu P, et al. Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Sci Rep. 2015;5:8113 pubmed publisher
    ..losses, zebrafish retained six cry genes, renamed as cry1aa (zcry1a in the old nomenclature), cry1ab (zcry1b), cry1ba (zcry2a), cry1bb (zcry2b), cry2 (zcry3) and cry3 (zcry4)...
  6. Kopp R, Billecke N, Legradi J, den Broeder M, Parekh S, Legler J. Bringing obesity to light: Rev-erbα, a central player in light-induced adipogenesis in the zebrafish?. Int J Obes (Lond). 2016;40:824-32 pubmed publisher
    ..As the pparβδ promoter includes three Rev-erbα binding sites, we hypothesize that pparβδ may be a direct target that ultimately activates Pparγ. ..
  7. Khan Z, Yumnamcha T, Rajiv C, Sanjita Devi H, Mondal G, Devi S, et al. Melatonin biosynthesizing enzyme genes and clock genes in ovary and whole brain of zebrafish (Danio rerio): Differential expression and a possible interplay. Gen Comp Endocrinol. 2016;233:16-31 pubmed publisher
    ..enzyme genes (Tph1a, Aanat1, Aanat2 and Hiomt) and clock associated genes (Bmal1a, Clock1a, Per1b, Per2 and Cry2a) in the ovary with a comparison to whole brain in normal (LD=12h L:12h D) and altered photic conditions (..
  8. Lahiri K, Vallone D, Gondi S, Santoriello C, Dickmeis T, Foulkes N. Temperature regulates transcription in the zebrafish circadian clock. PLoS Biol. 2005;3:e351 pubmed
    ..Together, our results imply that several key transcriptional regulatory elements at the core of the zebrafish clock respond to temperature. ..
  9. Amaral I, Johnston I. Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish. Am J Physiol Regul Integr Comp Physiol. 2012;302:R193-206 pubmed publisher
    ..The role of circadian clocks in regulating muscle maintenance and growth are discussed. ..

More Information


  1. Weger M, Weger B, Diotel N, Rastegar S, Hirota T, Kay S, et al. Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Dev Biol. 2013;380:259-73 pubmed publisher
    ..Finally, it allows mapping of clock activity in the brain of a vertebrate model organism with prominent adult neurogenesis and high regeneration capacity. ..
  2. Ren D, Ji C, Wang X, Wang H, Hu B. Endogenous melatonin promotes rhythmic recruitment of neutrophils toward an injury in zebrafish. Sci Rep. 2017;7:4696 pubmed publisher
    ..Together, our findings provide evidence that endogenous melatonin promotes rhythmic migration of neutrophils through cytokines in zebrafish. ..
  3. Pando M, Sassone Corsi P. Unraveling the mechanisms of the vertebrate circadian clock: zebrafish may light the way. Bioessays. 2002;24:419-26 pubmed
    ..This review focuses on the advantages of using the zebrafish to study the development of the vertebrate circadian system and light-dependent signaling to the clock. ..
  4. Li Y, Li G, Wang H, Du J, Yan J. Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish. PLoS Comput Biol. 2013;9:e1002940 pubmed publisher
    ..Our study describes a systematic method to discover previously unidentified TFs involved in circadian physiology in complex organisms. ..
  5. Chen Q, Li C, Gong Z, Chan E, Snyder S, Lam S. Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 2017;172:429-439 pubmed publisher
    ..The common deregulated genes with the associated biological processes and morphological changes can be used for biological inference of glucocorticoid exposure in fish for future studies. ..
  6. Zhao Y, Zhang K, Fent K. Regulation of zebrafish (Danio rerio) locomotor behavior and circadian rhythm network by environmental steroid hormones. Environ Pollut. 2018;232:422-429 pubmed publisher
    ..Our results suggest that steroid hormones can modulate the circadian molecular network in zebrafish and provide novel insights into their mode of actions and potential environmental risks. ..