Gene Symbol: crhr1
Description: corticotropin releasing hormone receptor 1
Alias: corticotropin-releasing factor receptor 1
Donizetti A, Grossi M, Pariante P, D Aniello E, Izzo G, Minucci S, et al
. Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: first evidence of nucleus incertus in fish. Dev Dyn. 2008;237:3864-9 pubmed publisher
..This pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish and rat brains, where only scattered cells express the gene in the periaqueductal gray. ..
Alderman S, Bernier N. Ontogeny of the corticotropin-releasing factor system in zebrafish. Gen Comp Endocrinol. 2009;164:61-9 pubmed publisher
..Overall, results from this study establish the zebrafish as a model species for research on stress during ontogeny and offer new insights into an HPI-axis independent function for the CRF system during embryogenesis. ..
Khor B, Jamil M, Adenan M, Shu Chien A. Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish. PLoS ONE. 2011;6:e28340 pubmed publisher
Jeffrey J, Gilmour K. Programming of the hypothalamic-pituitary-interrenal axis by maternal social status in zebrafish (Danio rerio). J Exp Biol. 2016;219:1734-43 pubmed publisher
..These results suggest programming of stress axis function in zebrafish offspring by maternal social status, emphasizing the importance of maternal environment and experience on offspring stress axis activity...
Bedell V, Wang Y, Campbell J, Poshusta T, Starker C, Krug R, et al
. In vivo genome editing using a high-efficiency TALEN system. Nature. 2012;491:114-8 pubmed publisher
..We further show successful germline transmission of both EcoRV and mloxP engineered chromosomes. This combined approach offers the potential to model genetic variation as well as to generate targeted conditional alleles. ..
Williams T, Bergstrome J, Scott J, Bernier N. CRF and urocortin 3 protect the heart from hypoxia/reoxygenation-induced apoptosis in zebrafish. Am J Physiol Regul Integr Comp Physiol. 2017;313:R91-R100 pubmed publisher
..We show that the CRF system is expressed in fish heart, is upregulated by hypoxia, and is cytoprotective. These findings identify a novel role for the CRF system in fish and a new strategy to tolerate hypoxia. ..
Massarsky A, Strek L, Craig P, Eisa Beygi S, Trudeau V, Moon T. Acute embryonic exposure to nanosilver or silver ion does not disrupt the stress response in zebrafish (Danio rerio) larvae and adults. Sci Total Environ. 2014;478:133-40 pubmed publisher