Gene Symbol: crhbp
Description: corticotropin releasing hormone binding protein
Alias: zgc:91905, corticotropin-releasing factor-binding protein, CRF-BP
Species: zebrafish

Top Publications

  1. Alderman S, Bernier N. Ontogeny of the corticotropin-releasing factor system in zebrafish. Gen Comp Endocrinol. 2009;164:61-9 pubmed publisher
    ..Overall, results from this study establish the zebrafish as a model species for research on stress during ontogeny and offer new insights into an HPI-axis independent function for the CRF system during embryogenesis. ..
  2. Gorissen M, Manuel R, Pelgrim T, Mes W, de Wolf M, Zethof J, et al. Differences in inhibitory avoidance, cortisol and brain gene expression in TL and AB zebrafish. Genes Brain Behav. 2015;14:428-38 pubmed publisher
    ..We conclude that AB fish show higher cortisol levels and no inhibitory avoidance than TL fish. The differential learning responses of these Danio strains may unmask genetically defined risks for stress-related disorders. ..
  3. Williams T, Bergstrome J, Scott J, Bernier N. CRF and urocortin 3 protect the heart from hypoxia/reoxygenation-induced apoptosis in zebrafish. Am J Physiol Regul Integr Comp Physiol. 2017;313:R91-R100 pubmed publisher
    ..We show that the CRF system is expressed in fish heart, is upregulated by hypoxia, and is cytoprotective. These findings identify a novel role for the CRF system in fish and a new strategy to tolerate hypoxia. ..
  4. Liu C, Yu H, Zhang X. Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere. 2013;93:2327-32 pubmed publisher
    ..Furthermore, we studied the effects of PTU or MET on the cross-talk between HPT and HPI axis. The results demonstrated that PTU and MET could affect cross-talk responses in zebrafish embryos/larvae. ..
  5. Manuel R, Gorissen M, Stokkermans M, Zethof J, Ebbesson L, van de Vis H, et al. The effects of environmental enrichment and age-related differences on inhibitory avoidance in zebrafish (Danio rerio Hamilton). Zebrafish. 2015;12:152-65 pubmed publisher
    ..Overall, our data show strong differences in inhibitory avoidance behavior between zebrafish of different ages and a clear reduction in avoidance behavior following housing under environmental enrichment. ..
  6. Zhang X, Zhong Y, Tian H, Wang W, Ru S. Impairment of the cortisol stress response mediated by the hypothalamus-pituitary-interrenal (HPI) axis in zebrafish (Danio rerio) exposed to monocrotophos pesticide. Comp Biochem Physiol C Toxicol Pharmacol. 2015;176-177:10-6 pubmed publisher
    ..Considered together, the reduced ability to elevate cortisol levels in response to an acute stress may be an endocrine dysfunction occurring in zebrafish subchronically exposed to MCP pesticide. ..
  7. Wirbisky S, Weber G, Sepúlveda M, Lin T, Jannasch A, Freeman J. An embryonic atrazine exposure results in reproductive dysfunction in adult zebrafish and morphological alterations in their offspring. Sci Rep. 2016;6:21337 pubmed publisher
    ..This study provides evidence to support atrazine as an EDC causing reproductive dysfunction and molecular alterations in adults exposed only during embryogenesis and morphological alterations in their offspring. ..
  8. van den Bos R, Zethof J, Flik G, Gorissen M. Light regimes differentially affect baseline transcript abundance of stress-axis and (neuro)development-related genes in zebrafish (Danio rerio, Hamilton 1822) AB and TL larvae. Biol Open. 2017;6:1692-1697 pubmed publisher
    ..The latter finding adds to the growing database of phenotypical differences between zebrafish of the AB and TL strain...
  9. Huising M, Metz J, van Schooten C, Taverne Thiele A, Hermsen T, Verburg van Kemenade B, et al. Structural characterisation of a cyprinid (Cyprinus carpio L.) CRH, CRH-BP and CRH-R1, and the role of these proteins in the acute stress response. J Mol Endocrinol. 2004;32:627-48 pubmed
    ..We conclude that these factors are actively involved in the regulation of acute stress responses in the teleost fish...

More Information


  1. Alderman S, Bernier N. Localization of corticotropin-releasing factor, urotensin I, and CRF-binding protein gene expression in the brain of the zebrafish, Danio rerio. J Comp Neurol. 2007;502:783-93 pubmed
  2. Donizetti A, Grossi M, Pariante P, D Aniello E, Izzo G, Minucci S, et al. Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: first evidence of nucleus incertus in fish. Dev Dyn. 2008;237:3864-9 pubmed publisher
    ..This pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish and rat brains, where only scattered cells express the gene in the periaqueductal gray. ..
  3. Massarsky A, Strek L, Craig P, Eisa Beygi S, Trudeau V, Moon T. Acute embryonic exposure to nanosilver or silver ion does not disrupt the stress response in zebrafish (Danio rerio) larvae and adults. Sci Total Environ. 2014;478:133-40 pubmed publisher
  4. Manuel R, Zethof J, Flik G, van den Bos R. Providing a food reward reduces inhibitory avoidance learning in zebrafish. Behav Processes. 2015;120:69-72 pubmed publisher
    ..These results suggest that providing rewards at fixed intervals alters fear avoidance behaviour, albeit modestly, in zebrafish. We discuss the data in the context of similar underlying brain structures in mammals and fish. ..
  5. van den Bos R, Mes W, Galligani P, Heil A, Zethof J, Flik G, et al. Further characterisation of differences between TL and AB zebrafish (Danio rerio): Gene expression, physiology and behaviour at day 5 of the larval stage. PLoS ONE. 2017;12:e0175420 pubmed publisher
    ..These results emphasise that differences between strains need to be taken into account to enhance reproducibility both within, and between, laboratories. ..
  6. Williams T, Bonham L, Bernier N. High environmental ammonia exposure has developmental-stage specific and long-term consequences on the cortisol stress response in zebrafish. Gen Comp Endocrinol. 2017;254:97-106 pubmed publisher
    ..Further, we demonstrate that HEA exposure at the larval stage can have persistent effects on the capacity to respond to stressors in later life. ..
  7. Manuel R, Gorissen M, Zethof J, Ebbesson L, van de Vis H, Flik G, et al. Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen long-fin zebrafish: stronger effects in the resting phase than in the active phase. J Exp Biol. 2014;217:3919-28 pubmed publisher
    ..Our data warrant further studies on the effect of UCS on stress axis-related genes, especially grβ; in mammals this receptor has been implicated in glucocorticoid resistance and depression. ..