Gene Symbol: crhb
Description: corticotropin releasing hormone b
Alias: crf, crh, zgc:101864, corticoliberin, crh1b
Species: zebrafish

Top Publications

  1. Löhr H, Ryu S, Driever W. Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages. Development. 2009;136:1007-17 pubmed publisher
    ..Our data suggest a common evolutionary origin of specific hypothalamic neuroendocrine and dopaminergic systems. ..
  2. Amir Zilberstein L, Blechman J, Sztainberg Y, Norton W, Reuveny A, Borodovsky N, et al. Homeodomain protein otp and activity-dependent splicing modulate neuronal adaptation to stress. Neuron. 2012;73:279-91 pubmed publisher
    Regulation of corticotropin-releasing hormone (CRH) activity is critical for the animal's adaptation to stressful challenges, and its dysregulation is associated with psychiatric disorders in humans...
  3. Piato A, Capiotti K, Tamborski A, Oses J, Barcellos L, Bogo M, et al. Unpredictable chronic stress model in zebrafish (Danio rerio): behavioral and physiological responses. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:561-7 pubmed publisher
    ..evaluated in relation to anxiety and exploratory behavior, memory, expression of corticotrophin-releasing factor (CRF) and glucocorticoid receptor (GR), and cortisol levels...
  4. Chandrasekar G, Lauter G, Hauptmann G. Distribution of corticotropin-releasing hormone in the developing zebrafish brain. J Comp Neurol. 2007;505:337-51 pubmed
    Corticotropin-releasing hormone (CRH) plays a central role in the physiological regulation of the hypothalamus-pituitary-adrenal/interrenal axis mediating endocrine, behavioral, autonomic, and immune responses to stress...
  5. Alderman S, Bernier N. Ontogeny of the corticotropin-releasing factor system in zebrafish. Gen Comp Endocrinol. 2009;164:61-9 pubmed publisher
    The corticotropin-releasing factor (CRF) system in fish functions to maintain homeostasis during stress in part by regulating cortisol production via the hypothalamus-pituitary-interrenal (HPI) axis...
  6. Fernandes A, Beddows E, Filippi A, Driever W. Orthopedia transcription factor otpa and otpb paralogous genes function during dopaminergic and neuroendocrine cell specification in larval zebrafish. PLoS ONE. 2013;8:e75002 pubmed publisher
    ..individual contributions to the specification of th expressing dopaminergic neuronal populations as well as of crh, oxt, avp, trh or sst1.1 expressing neuroendocrine cells...
  7. Fernandes A, Fero K, Arrenberg A, Bergeron S, Driever W, Burgess H. Deep brain photoreceptors control light-seeking behavior in zebrafish larvae. Curr Biol. 2012;22:2042-7 pubmed publisher
    ..Our findings shed light on the identity and function of deep brain photoreceptors and suggest that otpa specifies an ancient population of sensory neurons that mediate behavioral responses to light. ..
  8. Fuzzen M, Van der Kraak G, Bernier N. Stirring up new ideas about the regulation of the hypothalamic-pituitary-interrenal axis in zebrafish (Danio rerio). Zebrafish. 2010;7:349-58 pubmed publisher
    ..These findings suggest that multiple genes at all levels of the HPI axis play an active role in the stimulation and termination of the cortisol stress response in zebrafish. ..
  9. Wang Y, Wu S, Chen J, Zhang C, Xu Z, Li G, et al. Single and joint toxicity assessment of four currently used pesticides to zebrafish (Danio rerio) using traditional and molecular endpoints. Chemosphere. 2018;192:14-23 pubmed publisher
    ..Taken together, increased toxicity might be triggered by the simultaneous presence of several pesticides in the aquatic environment, which seriously damaged the non-target organisms...

More Information


  1. Sun H, Li H, Xiang P, Zhang X, Ma L. Short-term exposure of arsenite disrupted thyroid endocrine system and altered gene transcription in the HPT axis in zebrafish. Environ Pollut. 2015;205:145-52 pubmed publisher
    ..3-1.4 times and modulated gene transcription in HPT axis. Our study showed AsIII caused oxidative damage, affected thyroid endocrine system and altered gene transcription in HPT axis in zebrafish. ..
  2. Cheng H, Yan W, Wu Q, Liu C, Gong X, Hung T, et al. Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity. Environ Pollut. 2017;230:981-988 pubmed publisher
    ..We regard these adverse effects as a parental transgenerational toxicity of MCLR. ..
  3. Jianjie C, Wenjuan X, Jinling C, Jie S, Ruhui J, Meiyan L. Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio). Aquat Toxicol. 2016;171:48-58 pubmed publisher
    ..The transcriptional levels of corticotrophin-releasing hormone (CRH), thyroid-stimulating hormone (TSH), thyroglobulin (TG), sodium iodide symporter (NIS), iodothyronine I (DIO1), and ..
  4. Jeffrey J, Gilmour K. Programming of the hypothalamic-pituitary-interrenal axis by maternal social status in zebrafish (Danio rerio). J Exp Biol. 2016;219:1734-43 pubmed publisher
    ..may reflect reduced hypothalamic-pituitary-interrenal (HPI) axis activity, because corticotropin-releasing factor (crf) and cytochrome p450 side chain cleavage enzyme (p450scc) mRNA levels also were lower in larvae from dominant ..
  5. Koch P, Löhr H, Driever W. A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons. PLoS ONE. 2014;9:e113829 pubmed publisher
    ..Our data indicate that attenuation of Cnot8 activity differentially affects mRNA levels of developmental control genes. ..
  6. Zhao X, Wang S, Li D, You H, Ren X. Effects of perchlorate on BDE-47-induced alteration thyroid hormone and gene expression of in the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Environ Toxicol Pharmacol. 2013;36:1176-85 pubmed publisher
    ..1a) and significantly down-regulated the expression of genes related to the regulation of the HPT axis (CRH and TSH?)...
  7. Ghisleni G, Capiotti K, da Silva R, Oses J, Piato A, Soares V, et al. The role of CRH in behavioral responses to acute restraint stress in zebrafish. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36:176-82 pubmed publisher
  8. Liu Z, Li D, Hu Q, Tang R, Li L. Effects of exposure to microcystin-LR at environmentally relevant concentrations on the metabolism of thyroid hormones in adult zebrafish (Danio rerio). Toxicon. 2016;124:15-25 pubmed publisher
    ..The transcription of corticotropin-releasing hormone (crh), thyroid-stimulating hormone (tsh), transthyretin (ttr), thyroid hormone receptors (trs) genes, and the activities ..
  9. Eachus H, Bright C, Cunliffe V, Placzek M, Wood J, Watt P. Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function. Hum Mol Genet. 2017;26:1992-2005 pubmed publisher
    ..rx3-derived ff1b+?neurons, implicated in anxiety-related behaviours, and corticotrophin releasing hormone (crh) neurons, key regulators of the stress axis, develop abnormally, and rx3-derived pomc+?neurons are disorganised...
  10. Fuzzen M, Bernier N, Van der Kraak G. Differential effects of 17?-estradiol and 11-ketotestosterone on the endocrine stress response in zebrafish (Danio rerio). Gen Comp Endocrinol. 2011;170:365-73 pubmed publisher
    ..blunted the cortisol response of male fish in vivo and in vitro and as well as corticotropin-releasing factor (crf) expression in the pre-optic area (POA) of the brain...
  11. Bräutigam L, Hillmer J, Söll I, Hauptmann G. Localized expression of urocortin genes in the developing zebrafish brain. J Comp Neurol. 2010;518:2978-95 pubmed publisher
    The corticotropin-releasing hormone (CRH) family consists of four paralogous genes, CRH and urocortins (UCNs) 1, 2, and 3...
  12. Huang G, Tian X, Fang X, Ji F. Waterborne exposure to bisphenol F causes thyroid endocrine disruption in zebrafish larvae. Chemosphere. 2016;147:188-94 pubmed publisher
    ..Treatment with BPF also significantly increased transcription of genes involved in thyroid hormone regulation (crh) and synthesis (nis and tg) as a compensatory mechanism for the decrease of T4 contents...
  13. Pavlidis M, Theodoridi A, Tsalafouta A. Neuroendocrine regulation of the stress response in adult zebrafish, Danio rerio. Prog Neuropsychopharmacol Biol Psychiatry. 2015;60:121-31 pubmed publisher
    ..acute stress affected significantly brain mRNA expression levels of several genes (corticotropin-releasing factor, crf; pro-opiomelanocortin, pomc; glucocorticoid receptor, gr; MR/GR ratio; prolactin, prl; hypocretin/orexin, hcrt; ..
  14. Grone B, Maruska K. Divergent evolution of two corticotropin-releasing hormone (CRH) genes in teleost fishes. Front Neurosci. 2015;9:365 pubmed publisher
    ..Our phylogenetic and synteny analyses indicate that two CRH genes, crha and crhb, evolved via duplication of crh1 early in the teleost lineage...
  15. Dhanasiri A, Fernandes J, Kiron V. Acclimation of zebrafish to transport stress. Zebrafish. 2013;10:87-98 pubmed publisher
    ..In addition, the relevant genes in hypothalamic-pituitary-interrenal (HPI) axis (crf in brain, mc2r, star, cyp11c1, and hsd11b2 in kidney), including that of mineralocorticoid receptor (mr in kidney), ..
  16. Chiu C, Rihel J, Lee D, Singh C, Mosser E, Chen S, et al. A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States. Neuron. 2016;89:842-56 pubmed publisher
    ..We show that Nmu-induced arousal requires Nmu receptor 2 and signaling via corticotropin releasing hormone (Crh) receptor 1...
  17. Nesan D, Vijayan M. Maternal Cortisol Mediates Hypothalamus-Pituitary-Interrenal Axis Development in Zebrafish. Sci Rep. 2016;6:22582 pubmed publisher
    ..This contrasting hormonal response corresponded with altered expression of key HPI axis genes, including crf, 11B hydroxylase, pomca, and star, which were upregulated in response to reduced cortisol availability and ..
  18. Vom Berg Maurer C, Trivedi C, Bollmann J, De Marco R, Ryu S. The Severity of Acute Stress Is Represented by Increased Synchronous Activity and Recruitment of Hypothalamic CRH Neurons. J Neurosci. 2016;36:3350-62 pubmed publisher
    ..Corticotropin-releasing hormone (CRH) released from the paraventricular nucleus of the hypothalamus is a major regulator of the HPA axis...
  19. Du J, Wang S, You H, Liu Z. Effects of ZnO nanoparticles on perfluorooctane sulfonate induced thyroid-disrupting on zebrafish larvae. J Environ Sci (China). 2016;47:153-164 pubmed publisher
    ..Our results also provide insight into the mechanism of disruption of the thyroid status by PFOS and nano-ZnO. ..
  20. Santos da Rosa J, Alcântara Barcellos H, Fagundes M, Variani C, Rossini M, Kalichak F, et al. Muscarinic receptors mediate the endocrine-disrupting effects of an organophosphorus insecticide in zebrafish. Environ Toxicol. 2017;32:1964-1972 pubmed publisher
    ..This appears to be mediated via muscarinic receptors, since the muscarinic antagonist scopolamine blocked these effects. ..
  21. Tu W, Xu C, Lu B, Lin C, Wu Y, Liu W. Acute exposure to synthetic pyrethroids causes bioconcentration and disruption of the hypothalamus-pituitary-thyroid axis in zebrafish embryos. Sci Total Environ. 2016;542:876-85 pubmed publisher
    ..In addition, the majority of the HPT axis-related genes examined, including CRH, TSHβ, TTR, UGT1ab, Pax8, Dio2 and TRα, were significantly upregulated in the presence of BF...
  22. Zhang D, Zhou E, Yang Z. Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae. PLoS ONE. 2017;12:e0176927 pubmed publisher
    ..After exposure to BPS, the mRNA expression of corticotrophin releasing hormone (crh) and thyroglobulin (tg) genes were up-regulated at ?10 ?g/L of BPS, in a dose-response manner...
  23. van den Bos R, Zethof J, Flik G, Gorissen M. Light regimes differentially affect baseline transcript abundance of stress-axis and (neuro)development-related genes in zebrafish (Danio rerio, Hamilton 1822) AB and TL larvae. Biol Open. 2017;6:1692-1697 pubmed publisher
    ..The latter finding adds to the growing database of phenotypical differences between zebrafish of the AB and TL strain...
  24. Liang Y, Huang G, Ying G, Liu S, Jiang Y, Liu S, et al. A time-course transcriptional kinetics of the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in zebrafish eleutheroembryos after exposure to norgestrel. Environ Toxicol Chem. 2015;34:112-9 pubmed publisher
    ..induce expression of Cyp19a1a, Cyp11b, Gnrh2, Gnrh3, and Lhb mRNAs but inhibit transcripts of Hsd11b2 and Crh genes above 5 ng L(-1) at different time points...
  25. Alderman S, Bernier N. Localization of corticotropin-releasing factor, urotensin I, and CRF-binding protein gene expression in the brain of the zebrafish, Danio rerio. J Comp Neurol. 2007;502:783-93 pubmed
    Our current understanding of the corticotropin-releasing factor (CRF) system distribution in the teleost brain is restricted by limited immunohistochemical studies and a lack of complete transcriptional distribution maps...
  26. Shi X, Liu C, Wu G, Zhou B. Waterborne exposure to PFOS causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Chemosphere. 2009;77:1010-8 pubmed publisher
    ..The expression of several genes in the HPT system, i.e., corticotropin-releasing factor (CRF), thyroid-stimulating hormone (TSH), sodium/iodide symporter (NIS), thyroglobulin (TG), thyroid peroxidase (TPO), ..
  27. Mahler J, Filippi A, Driever W. DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish. J Neurosci. 2010;30:16621-35 pubmed publisher
    ..Rather, DeltaA/D limits the size of the sim1a- and otpa-expressing precursor pool from which dopaminergic neurons differentiate. ..
  28. Chandrasekar G, Arner A, Kitambi S, Dahlman Wright K, Lendahl M. Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish. Neurotoxicol Teratol. 2011;33:752-64 pubmed publisher
    ..These data suggest that 4-NP enduringly affects the embryonic development in zebrafish and that this compound might exert these deleterious effects through diverse signaling pathways. ..
  29. Yu L, Lam J, Guo Y, Wu R, Lam P, Zhou B. Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish. Environ Sci Technol. 2011;45:10652-9 pubmed publisher
    ..This increased T4 was accompanied by decreased mRNA levels of corticotropin-releasing hormone (CRH) and thyrotropin ?-subunit (TSH?) in the brain...
  30. Huising M, Metz J, van Schooten C, Taverne Thiele A, Hermsen T, Verburg van Kemenade B, et al. Structural characterisation of a cyprinid (Cyprinus carpio L.) CRH, CRH-BP and CRH-R1, and the role of these proteins in the acute stress response. J Mol Endocrinol. 2004;32:627-48 pubmed
    ..factors regulating the initiation of the acute stress response in common carp: corticotrophin-releasing hormone (CRH), CRH-receptor 1 (CRH-R1) and CRH-binding protein (CRH-BP)...
  31. Dickmeis T, Lahiri K, Nica G, Vallone D, Santoriello C, Neumann C, et al. Glucocorticoids play a key role in circadian cell cycle rhythms. PLoS Biol. 2007;5:e78 pubmed
    ..Instead, they act in concert with a systemic signaling environment of which glucocorticoids are an essential part. ..
  32. Forsatkar M, Nematollahi M, Rafiee G, Farahmand H, Lawrence C. Effects of the prebiotic mannan-oligosaccharide on the stress response of feed deprived zebrafish (Danio rerio). Physiol Behav. 2017;180:70-77 pubmed publisher showed higher baseline cortisol levels than the other treatments, which was in line with higher expression of CRH gene in fish subjected to this treatment...
  33. Zhu Y, Su G, Yang D, Zhang Y, Yu L, Li Y, et al. Time-dependent inhibitory effects of Tris(1, 3-dichloro-2-propyl) phosphate on growth and transcription of genes involved in the GH/IGF axis, but not the HPT axis, in female zebrafish. Environ Pollut. 2017;229:470-478 pubmed publisher
  34. Wagle M, Mathur P, Guo S. Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol. J Neurosci. 2011;31:214-24 pubmed publisher
    ..Here we report the identification of corticotropin-releasing factor (CRF) as a critical component of the camouflage response pathway...
  35. Pavlidis M, Sundvik M, Chen Y, Panula P. Adaptive changes in zebrafish brain in dominant-subordinate behavioral context. Behav Brain Res. 2011;225:529-37 pubmed publisher
    ..involved in the functioning of the hypothalamus-hypophysis-interrenal axis (corticotropin releasing factor, CRF; glucocorticoid receptor, GR; mineralocorticoid receptor, MR); arginine vasotocin, AVT), in the biosynthesis and ..
  36. Chakravarty S, Reddy B, Sudhakar S, Saxena S, Das T, Meghah V, et al. Chronic unpredictable stress (CUS)-induced anxiety and related mood disorders in a zebrafish model: altered brain proteome profile implicates mitochondrial dysfunction. PLoS ONE. 2013;8:e63302 pubmed publisher
    ..The common molecular markers of rodent anxiety and related disorders, corticotropin-releasing factor (CRF), calcineurin (ppp3r1a) and phospho cyclic AMP response element binding protein (pCREB), were also replicated in ..
  37. Luo L, Chen A, Hu C, Lu W. Dynamic expression pattern of corticotropin-releasing hormone, urotensin I and II genes under acute salinity and temperature challenge during early development of zebrafish. Fish Physiol Biochem. 2014;40:1877-86 pubmed publisher
    Corticotropin-releasing hormone (CRH), urotensin I (UI) and urotensin II (UII) are found throughout vertebrate species from fish to human...
  38. Oswald M, Drew R, Racine M, Murdoch G, Robison B. Is behavioral variation along the bold-shy continuum associated with variation in the stress axis in zebrafish?. Physiol Biochem Zool. 2012;85:718-28 pubmed publisher
    ..The bold and shy zebrafish lines will be valuable tools for additional research into the relationship between stress and behavior and the mechanisms regulating sexual dimorphism in these traits. ..
  39. Massarsky A, Strek L, Craig P, Eisa Beygi S, Trudeau V, Moon T. Acute embryonic exposure to nanosilver or silver ion does not disrupt the stress response in zebrafish (Danio rerio) larvae and adults. Sci Total Environ. 2014;478:133-40 pubmed publisher
    ..were not affected by either AgNPs or Ag(+); however, the transcript levels of corticotropin releasing factor (CRF), CRF-binding protein (CRF-BP), CRF-receptor 2 (CRF-R2), and pro-opiomelanocortin (POMCb) were significantly ..
  40. Kim S, Jung J, Lee I, Jung D, Youn H, Choi K. Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines. Aquat Toxicol. 2015;160:188-96 pubmed publisher
    ..The down-regulation of the crh and tshβ genes in the zebrafish larvae suggests the activation of a central regulatory feedback mechanism ..
  41. Tokarz J, Norton W, Moller G, Hrabe de Angelis M, Adamski J. Zebrafish 20?-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response. PLoS ONE. 2013;8:e54851 pubmed publisher
    ..Our experiments show that 20?-HSD type 2, together with 11?-HSD type 2, represents a short pathway in zebrafish to rapidly inactivate and excrete cortisol. Therefore, 20?-HSD type 2 is an important enzyme in stress response. ..
  42. Gorissen M, Manuel R, Pelgrim T, Mes W, de Wolf M, Zethof J, et al. Differences in inhibitory avoidance, cortisol and brain gene expression in TL and AB zebrafish. Genes Brain Behav. 2015;14:428-38 pubmed publisher
    ..We conclude that AB fish show higher cortisol levels and no inhibitory avoidance than TL fish. The differential learning responses of these Danio strains may unmask genetically defined risks for stress-related disorders. ..
  43. Liu C, Yu H, Zhang X. Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere. 2013;93:2327-32 pubmed publisher
    ..Furthermore, we studied the effects of PTU or MET on the cross-talk between HPT and HPI axis. The results demonstrated that PTU and MET could affect cross-talk responses in zebrafish embryos/larvae. ..
  44. Liang X, Yu L, Gui W, Zhu G. Exposure to difenoconazole causes changes of thyroid hormone and gene expression levels in zebrafish larvae. Environ Toxicol Pharmacol. 2015;40:983-7 pubmed publisher
    ..Moreover, the mRNA transcription of corticotrophin-releasing hormone (crh), thyroid-stimulating hormone (tshβ), transthyretin (ttr), thyronine deiodinase (dio1 and dio2), uridine ..
  45. Liang X, Li J, Martyniuk C, Wang J, Mao Y, Lu H, et al. Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos. Chemosphere. 2017;182:22-30 pubmed publisher
    ..Taken together, our results indicate that BUVSs can potentially impact the thyroid system, and that this is dependent upon the type or structure of BUVSs. ..
  46. Williams T, Bergstrome J, Scott J, Bernier N. CRF and urocortin 3 protect the heart from hypoxia/reoxygenation-induced apoptosis in zebrafish. Am J Physiol Regul Integr Comp Physiol. 2017;313:R91-R100 pubmed publisher
    ..Given the key role of the CRF system in coordinating the response to stressors and its cardioprotective actions against ischemia in mammals, we ..
  47. Facchinello N, Skobo T, Meneghetti G, Colletti E, Dinarello A, Tiso N, et al. nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor. Sci Rep. 2017;7:4371 pubmed publisher
    ..Mutants show higher levels of whole-body cortisol associated with overstimulated basal levels of crh and pomca transcripts along the HPI axis, which is unresponsive to a mechanical stressor...
  48. Herget U, Wolf A, Wullimann M, Ryu S. Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae. J Comp Neurol. 2014;522:1542-64 pubmed publisher reconstructing the locations of cells producing zebrafish neuropeptides found in the mammalian PVN (CCK, CRH, ENK, NTS, SS, VIP, OXT, AVP), we provide the first 3D arrangement map of NPO neuropeptides in the larval zebrafish ..
  49. Kurrasch D, Nevin L, Wong J, Baier H, Ingraham H. Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Dev. 2009;4:22 pubmed publisher
    ..Based on our collective findings, we speculate that neuroendocrine transcriptional programs adapt dynamically to both the supply and demand for neuropeptides to ensure adequate homeostatic responses. ..
  50. van den Bos R, Mes W, Galligani P, Heil A, Zethof J, Flik G, et al. Further characterisation of differences between TL and AB zebrafish (Danio rerio): Gene expression, physiology and behaviour at day 5 of the larval stage. PLoS ONE. 2017;12:e0175420 pubmed publisher
    ..These results emphasise that differences between strains need to be taken into account to enhance reproducibility both within, and between, laboratories. ..
  51. Filby A, Paull G, Bartlett E, Van Look K, Tyler C. Physiological and health consequences of social status in zebrafish (Danio rerio). Physiol Behav. 2010;101:576-87 pubmed publisher
    ..The wide-ranging physiological differences seen between dominant and subordinate zebrafish as a consequence of their social status suggest negative health impacts for subordinates after prolonged durations in those hierarchies. ..
  52. Jia P, Ma Y, Lu C, Mirza Z, Zhang W, Jia Y, et al. The Effects of Disturbance on Hypothalamus-Pituitary-Thyroid (HPT) Axis in Zebrafish Larvae after Exposure to DEHP. PLoS ONE. 2016;11:e0155762 pubmed publisher
    ..exposure to DEHP, the mRNA expressions of thyroid stimulating hormone (tshβ) and corticotrophin releasing hormone (crh) genes were increased in a concentration dependent manner, respectively...
  53. Tu W, Xu C, Jin Y, Lu B, Lin C, Wu Y, et al. Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence. Aquat Toxicol. 2016;175:39-46 pubmed publisher
    ..Both in vivo and in silico studies clearly disclosed that PM potentially disrupts the thyroid endocrine system in fish. This study provides a rapid and cost-effective approach for identifying THDCs and the underlying mechanisms. ..