Gene Symbol: crfb1
Description: cytokine receptor family member b1
Alias: fa94a03, wu:fa94a03, zgc:165377, cytokine receptor family member b1, ifnar2
Aggad D, Mazel M, Boudinot P, Mogensen K, Hamming O, Hartmann R, et al
. The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains. J Immunol. 2009;183:3924-31 pubmed publisher
..Both receptor complexes include a common short chain receptor (CRFB5) and a specific long chain receptor (CRFB1 or CRFB2).
Gabor K, Stevens C, Pietraszewski M, Gould T, Shim J, Yoder J, et al
. Super resolution microscopy reveals that caveolin-1 is required for spatial organization of CRFB1 and subsequent antiviral signaling in zebrafish. PLoS ONE. 2013;8:e68759 pubmed publisher
..Viral infection leads to a downregulation in Caveolin-1b (Cav-1b), disrupting clusters of CRFB1, a zebrafish type I interferon receptor (-R) subunit...
Palha N, Guivel Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, et al
. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013;9:e1003619 pubmed publisher
..Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus. ..
Chen H, Liu W, Wang B, Mao H, Sun Z, Hou Q, et al
. Cloning, identification of the two cytokine receptor family B subunits CRFB1 and CRFB5 from grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;45:211-20 pubmed publisher
..Phylogenetic tree analysis suggested that CiCRFB1 and CiCRFB5 shared highly homology to Danio rerio CRFB1 and CRFB5 respectively...
Aggad D, Stein C, Sieger D, Mazel M, Boudinot P, Herbomel P, et al
. In vivo analysis of Ifn-?1 and Ifn-?2 signaling in zebrafish. J Immunol. 2010;185:6774-82 pubmed publisher
..These results shed new light on the evolution of the Ifn-? signaling in fish and tetrapods and contribute toward an integrated view of the innate immune regulation in vertebrates...
Sun B, Greiner Tollersrud L, Koop B, Robertsen B. Atlantic salmon possesses two clusters of type I interferon receptor genes on different chromosomes, which allows for a larger repertoire of interferon receptors than in zebrafish and mammals. Dev Comp Immunol. 2014;47:275-86 pubmed publisher
Mammalian type I interferons (IFNs) signal through a receptor composed of the IFNAR1 and IFNAR2 chains...