Gene Symbol: cpt1aa
Description: carnitine palmitoyltransferase 1Aa (liver)
Alias: cpt1a, si:dkey-56p7.8, carnitine palmitoyltransferase 1A, carnitine palmitoyltransferase 1A (liver)
Shieh Y, Chang Y, Hong J, Chen L, Jou L, Hsu C, et al
. Increase of hepatic fat accumulation by liver specific expression of Hepatitis B virus X protein in zebrafish. Biochim Biophys Acta. 2010;1801:721-30 pubmed publisher
..In addition, GBXs with transmissible NASH-like phenotypes provide a promising model for studying liver disease. ..
Dai W, Wang K, Zheng X, Chen X, Zhang W, Zhang Y, et al
. High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs. Nutr Metab (Lond). 2015;12:42 pubmed publisher
..the expression levels of endoplasmic reticulum (ER) stress and lipolytic molecules (atf6, hspa5, hsp90b1, pparab, cpt1a and acox3) were significantly up-regulated in the liver of HF and HFC diets-fed larvae compared to the control, ..
Ho J, Hsiao C, Kawakami K, Tse W. Triclosan (TCS) exposure impairs lipid metabolism in zebrafish embryos. Aquat Toxicol. 2016;173:29-35 pubmed publisher
..This study showed that 250Î¼g/L TCS exposure does not affect normal embryogenesis or organogenesis; however, there are concerns regarding possible impairment of lipid metabolism. ..
Cheng J, Lv S, Nie S, Liu J, Tong S, Kang N, et al
. Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish. Aquat Toxicol. 2016;176:45-52 pubmed publisher
..of nuclear receptors (nr1h3, rara, rxrgb, nr1l2) and the genes associated with fatty acid oxidation (acox1, acadm, cpt1a)...
Jin C, Luo T, Zhu Z, Pan Z, Yang J, Wang W, et al
. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2017;202:85-93 pubmed publisher
..These results indicated that exposure to IMZ could cause gut microbiota dysbiosis and metabolic disorders in adult zebrafish. ..
Zheng X, Dai W, Chen X, Wang K, Zhang W, Liu L, et al
. Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. J Biomed Sci. 2015;22:105 pubmed publisher
Zhang W, Liu Y, Zhang H, Dai J. Proteomic analysis of male zebrafish livers chronically exposed to perfluorononanoic acid. Environ Int. 2012;42:20-30 pubmed publisher
..Other potential modes should be further investigated. ..
Gut P, Baeza Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, et al
. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013;9:97-104 pubmed publisher
..Thus, using a whole-organism screening strategy, this study has identified new small-molecule activators of fasting metabolism. ..
Seiliez I, Médale F, Aguirre P, Larquier M, Lanneretonne L, Alami Durante H, et al
. Postprandial regulation of growth- and metabolism-related factors in zebrafish. Zebrafish. 2013;10:237-48 pubmed publisher
..Together, these results highlight some specificity of the zebrafish metabolism and demonstrate the interest and the limits of this species as a model organism for nutritional physiology studies. ..