Gene Symbol: cpa5
Description: carboxypeptidase A5
Alias: cb1060, cpa, wu:fb68f03, carboxypeptidase A, carbA
Species: zebrafish

Top Publications

  1. Dobson J, Seibert J, Teh E, Da as S, Fraser R, Paw B, et al. Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination. Blood. 2008;112:2969-72 pubmed publisher
    ..Carboxypeptidase A5 (cpa5), a MC-specific enzyme, is expressed in zebrafish blood cells beginning at 24 hours post fertilization (hpf)...
  2. Jiang Z, Song J, Qi F, Xiao A, An X, Liu N, et al. Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish. PLoS Biol. 2008;6:e293 pubmed publisher
    ..Knocking down exdpf by morpholino abolished ectopic carboxypeptidase A (cpa) expression induced by RA...
  3. Wang H, Zhou Q, Kesinger J, Norris C, Valdez C. Heme regulates exocrine peptidase precursor genes in zebrafish. Exp Biol Med (Maywood). 2007;232:1170-80 pubmed
    ..Here we report that six exocrine peptidase precursor genes, carboxypeptidase A, trypsin precursor, trypsin like, chymotrypsinogen B1, chymotrypsinogen 1-like, and elastase 2 like, are ..
  4. Yee N, Lorent K, Pack M. Exocrine pancreas development in zebrafish. Dev Biol. 2005;284:84-101 pubmed
    ..By contrast, analyses of mind bomb mutants and jagged morpholino-injected larvae suggest that Notch signaling principally regulates ductal differentiation of bipotential exocrine progenitors. ..
  5. Da as S, Teh E, Dobson J, Nasrallah G, McBride E, Wang H, et al. Zebrafish mast cells possess an Fc?RI-like receptor and participate in innate and adaptive immune responses. Dev Comp Immunol. 2011;35:125-34 pubmed publisher
    ..Whole mount in situ hybridization on 7-day embryos demonstrated co-localization of cpa5, a MC-specific marker, with myd88, a toll-like receptor adaptor, and zebrafish Fc?RI subunit homologs...
  6. Nissim S, Weeks O, Talbot J, Hedgepeth J, Wucherpfennig J, Schatzman Bone S, et al. Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Dev Biol. 2016;418:108-123 pubmed publisher
    ..These findings define critical iterative and pleiotropic roles for Nr5a2 at distinct stages of pancreas and liver organogenesis, and provide novel perspectives for interpreting the role of Nr5a2 in disease. ..
  7. Shao T, Zhu L, Nie L, Shi W, Dong W, Xiang L, et al. Characterization of surface phenotypic molecules of teleost dendritic cells. Dev Comp Immunol. 2015;49:38-43 pubmed publisher
    ..Our findings contributed to the current understanding of the evolutionary history of DCs and the DC-regulatory mechanisms of adaptive immunity. ..
  8. Hozumi S, Hirabayashi R, Yoshizawa A, Ogata M, Ishitani T, Tsutsumi M, et al. DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafish. PLoS ONE. 2012;7:e33675 pubmed publisher
    ..Therefore, our results suggest a model in which zebrafish Ddx46 is required for the development of the digestive organs and brain, possibly through the control of pre-mRNA splicing. ..
  9. Da as S, Coombs A, Balci T, Grondin C, Ferrando A, Berman J. The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood. 2012;119:3585-94 pubmed publisher
    ..Colocalization studies demonstrated zebrafish notch receptor expression in cells expressing carboxypeptidase A5 (cpa5), a zebrafish mast cell-specific marker...

More Information


  1. Qi F, Song J, Yang H, Gao W, Liu N, Zhang B, et al. Mmp23b promotes liver development and hepatocyte proliferation through the tumor necrosis factor pathway in zebrafish. Hepatology. 2010;52:2158-66 pubmed publisher
    ..Because mmp23b/MMP23B is highly conserved, our findings in zebrafish warrant further investigation of its role in regulating liver development in mammals. ..
  2. Lyons P, Ma L, Baker R, Fricker L. Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. PLoS ONE. 2010;5:e12967 pubmed publisher
    ..No other zebrafish CPA gene exhibited a similar expression profile...
  3. Alexa K, Choe S, Hirsch N, Etheridge L, Laver E, SAGERSTROM C. Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish. PLoS ONE. 2009;4:e8261 pubmed publisher
    ..gene expression is less affected in the mutant, with varying degrees of residual expression observed for pdx1, carbA, hhex, prox1, sid4, transferrin and ifabp...
  4. Sullivan Brown J, Bisher M, Burdine R. Embedding, serial sectioning and staining of zebrafish embryos using JB-4 resin. Nat Protoc. 2011;6:46-55 pubmed publisher
    ..Overall, we reinforce that plastic embedding can provide higher resolution of cellular details and is a valuable tool for cellular and morphological studies in zebrafish. ..
  5. diIorio P, Alexa K, Choe S, Etheridge L, SAGERSTROM C. TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm. Dev Biol. 2007;304:221-31 pubmed
    ..Our data indicate that meis3 and pbx4 regulate shh expression in anterior endoderm, thereby influencing patterning and growth of the foregut. ..
  6. Kim H, Schleiffarth J, Jessurun J, Sumanas S, Petryk A, Lin S, et al. Wnt5 signaling in vertebrate pancreas development. BMC Biol. 2005;3:23 pubmed
    ..This study opens the door for further investigation into a role of Wnt signaling in vertebrate organ development and disease. ..
  7. Kim H, Sumanas S, Palencia Desai S, Dong Y, Chen J, Lin S. Genetic analysis of early endocrine pancreas formation in zebrafish. Mol Endocrinol. 2006;20:194-203 pubmed
    ..Further study on these mutants will reveal important information on novel genes involved in pancreatic islet cell specification and morphogenesis. ..
  8. Zhang S, Xu M, Huang J, Tang L, Zhang Y, Wu J, et al. Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish. Dis Model Mech. 2014;7:837-45 pubmed publisher
    ..These results provide novel insights into the regulation of exocrine function, as well as the pathogenesis of porphyria, and should be useful for designing new therapies for both types of disease. ..