Gene Symbol: COUP
Description: nuclear receptor subfamily 2, group F, member 5
Alias: COUP, couptf, svp46, nuclear receptor subfamily 2 group F member 5, COUPTFgamma, seven-up related 46, steroid receptor homolog SVP 46
Tsai S, Tsai M. Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr Rev. 1997;18:229-40 pubmed
Lupo G, Gestri G, O Brien M, Denton R, Chandraratna R, Ley S, et al
. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proc Natl Acad Sci U S A. 2011;108:8698-703 pubmed publisher
..Furthermore, the identification of two cohorts of genes implicated in ventral eye morphogenesis may help to elucidate the genetic basis of ocular coloboma in humans. ..
Love C, Prince V. Expression and retinoic acid regulation of the zebrafish nr2f orphan nuclear receptor genes. Dev Dyn. 2012;241:1603-15 pubmed publisher
..Our finding that RA positively regulates nr2f1a expression in the trunk supports the possibility that Nr2fs function in a negative feedback loop to modulate RA signaling in this region. ..
Chen J, Carney S, Peterson R, Heideman W. Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart. Physiol Genomics. 2008;33:148-58 pubmed publisher
..Among the genes rapidly induced by RA was Nr2F5, a member of the COUP-TF family of transcriptional repressors...
Gauchat D, Escriva H, Miljkovic Licina M, Chera S, Langlois M, Begue A, et al
. The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates. Dev Biol. 2004;275:104-23 pubmed
In bilaterians, COUP-TF nuclear receptors participate in neurogenesis and/or CNS patterning...
Kashyap B, Frey R, Stenkamp D. Ethanol-induced microphthalmia is not mediated by changes in retinoic acid or sonic hedgehog signaling during retinal neurogenesis. Alcohol Clin Exp Res. 2011;35:1644-61 pubmed publisher
..These studies suggest that FASD intervention strategies based upon augmentation of RA or Shh signaling may not prevent ethanol-induced microphthalmia. ..
Mitchell D, Stevens C, Frey R, Hunter S, Ashino R, Kawamura S, et al
. Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish. PLoS Genet. 2015;11:e1005483 pubmed publisher
..This is the first evidence that an extracellular signal may regulate differential expression of opsin genes in a tandemly duplicated array. ..
Valdivia L, Lamb D, Horner W, Wierzbicki C, Tafessu A, Williams A, et al
. Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish. Development. 2016;143:1087-98 pubmed publisher
..Together, our results support a model in which dorsally expressed gdf6a limits RA pathway activity to control the transition from proliferation to differentiation in the growing eye. ..