Gene Symbol: col8a1a
Description: collagen, type VIII, alpha 1a
Alias: Col8A1.1, col8a1, si:ch211-283e2.6, wu:fb18b08, collagen alpha-1(VIII) chain, collagen type VIII alpha 1, gul, gulliver, lev, leviathan
Gansner J, Gitlin J. Essential role for the alpha 1 chain of type VIII collagen in zebrafish notochord formation. Dev Dyn. 2008;237:3715-26 pubmed publisher
..We now report the cloning and further characterization of one such mutant, gulliver(m208) (gul(m208))...
Stemple D, Solnica Krezel L, Zwartkruis F, Neuhauss S, Schier A, Malicki J, et al
. Mutations affecting development of the notochord in zebrafish. Development. 1996;123:117-28 pubmed
Sandoval I, Manos E, Van Wagoner R, Delacruz R, Edes K, Winge D, et al
. Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F. Chem Biol. 2013;20:753-63 pubmed publisher
..Our data support this mechanism of action for kalihinol F and the utility of zebrafish as an effective system for identifying therapeutic and target pathways. ..
Lien H, Yang C, Cheng C, Hung C, Liao W, Hwang P, et al
. A novel zinc finger protein 219-like (ZNF219L) is involved in the regulation of collagen type 2 alpha 1a (col2a1a) gene expression in zebrafish notochord. Int J Biol Sci. 2013;9:872-86 pubmed publisher
..Taken together, our results reveal that ZNF219L is involved in regulating the expression of col2a1a in zebrafish notochord specifically. ..
Gray R, Wilm T, Smith J, Bagnat M, Dale R, Topczewski J, et al
. Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. Dev Biol. 2014;386:72-85 pubmed publisher
..We characterize three recessive zebrafish leviathan/col8a1a mutant alleles ((m531, vu41, vu105)) that disrupt collagen type VIII alpha1a (col8a1a), and cause ..
Garcia J, Bagwell J, Njaine B, Norman J, Levic D, Wopat S, et al
. Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord. Curr Biol. 2017;27:1982-1989.e3 pubmed publisher
..This work reveals a novel structural role for caveolae in vertebrates and provides unique insights into the mechanisms that safeguard notochord and spine development. ..