Gene Symbol: cntn2
Description: contactin 2
Alias: si:dz37k09.2, tag1, contactin-2, transiently expressed axonal glycoprotein
Species: zebrafish
Products:     cntn2

Top Publications

  1. Chandrasekhar A, Moens C, Warren J, Kimmel C, Kuwada J. Development of branchiomotor neurons in zebrafish. Development. 1997;124:2633-44 pubmed
    ..These results demonstrate that rhombomere-specific cues and ventral midline cells play important roles in the development of the branchiomotor pathways. ..
  2. Sittaramane V, Sawant A, Wolman M, Maves L, Halloran M, Chandrasekhar A. The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish. Dev Biol. 2009;325:363-73 pubmed publisher
    ..We show here that the cell adhesion molecule Transient Axonal Glycoprotein (Tag1) is necessary for the migration of the facial branchiomotor neurons (FBMNs) in the zebrafish hindbrain...
  3. Bianco I, Carl M, Russell C, Clarke J, Wilson S. Brain asymmetry is encoded at the level of axon terminal morphology. Neural Dev. 2008;3:9 pubmed publisher
    ..Although signaling from the parapineal is essential for the development of normal lateralization, additional factors clearly act during development to confer left-right identity upon neurons in this highly conserved circuit. ..
  4. Wolman M, Sittaramane V, Essner J, Yost H, Chandrasekhar A, Halloran M. Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo. Neural Dev. 2008;3:6 pubmed publisher
    ..Laminin-alpha1 does not regulate axon-axon interactions, but does influence neuronal polarity and directional guidance. ..
  5. Wada H, Iwasaki M, Sato T, Masai I, Nishiwaki Y, Tanaka H, et al. Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos. Development. 2005;132:2273-85 pubmed
    ..The dual roles of the scrb1 gene in both neuronal migration and CE provide a novel insight into the underlying mechanisms of cell movement in vertebrate development. ..
  6. Carl M, Bianco I, Bajoghli B, Aghaallaei N, Czerny T, Wilson S. Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries. Neuron. 2007;55:393-405 pubmed
    ..We identify a second role for the Wnt pathway in the left/right regulation of LPM Nodal pathway gene expression, and finally, we show that at later stages Axin1 is required for the elaboration of concordant neuroanatomical asymmetries. ..
  7. Liu Y, Halloran M. Central and peripheral axon branches from one neuron are guided differentially by Semaphorin3D and transient axonal glycoprotein-1. J Neurosci. 2005;25:10556-63 pubmed
  8. Wada H, Tanaka H, Nakayama S, Iwasaki M, Okamoto H. Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Development. 2006;133:4749-59 pubmed
    ..e. preventing integration of differentiated neurons into the neuroepithelial layer). This contrasts markedly with their reported role in reintegration of neuroepithelial daughter cells into the neuroepithelial layer after cell division. ..
  9. Walsh G, Grant P, Morgan J, Moens C. Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration. Development. 2011;138:3033-42 pubmed publisher
    ..These results define a role for Nhsl1b as a neuronal effector of PCP signaling and indicate that proper FBM neuron migration is directly controlled by PCP signaling between the epithelium and the migrating neurons. ..

More Information


  1. Volkmann K, Rieger S, Babaryka A, Köster R. The zebrafish cerebellar rhombic lip is spatially patterned in producing granule cell populations of different functional compartments. Dev Biol. 2008;313:167-80 pubmed
    ..Thus, our findings offer an explanation for how specific functional cerebellar circuitries are laid down by spatio-temporal patterning of cerebellar germinal zones during early brain development. ..
  2. Woltering J, Durston A. MiR-10 represses HoxB1a and HoxB3a in zebrafish. PLoS ONE. 2008;3:e1396 pubmed publisher
  3. Jászai J, Reifers F, Picker A, Langenberg T, Brand M. Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity. Development. 2003;130:6611-23 pubmed
    ..followed by the lack of early and late cerebellar-specific gene expression (zath1/atoh1, gap43, tag1/cntn2, neurod, zebrin II). The Locus coeruleus (LC) derived from rostral rhombomere 1 is also absent in the mutants...
  4. Hüsken U, Stickney H, Gestri G, Bianco I, Faro A, Young R, et al. Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons. Curr Biol. 2014;24:2217-27 pubmed publisher
    ..Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries. ..
  5. Chandrasekhar A, Schauerte H, Haffter P, Kuwada J. The zebrafish detour gene is essential for cranial but not spinal motor neuron induction. Development. 1999;126:2727-37 pubmed
  6. Diekmann H, Stuermer C. Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding. J Comp Neurol. 2009;513:38-50 pubmed publisher
    ..Without Neurolin-b, RGC axons grow in highly aberrant routes along the optic tract and/or fail to reach the optic tectum. Thus, the zebrafish Neurolin paralogs are involved in distinct steps of retinotectal development. ..
  7. Jacobson S, BIRKHOLZ D, McNamara M, Bharate S, George K. Subacute developmental exposure of zebrafish to the organophosphate pesticide metabolite, chlorpyrifos-oxon, results in defects in Rohon-Beard sensory neuron development. Aquat Toxicol. 2010;100:101-11 pubmed publisher
  8. Sittaramane V, Pan X, Glasco D, Huang P, Gurung S, Bock A, et al. The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. Dev Biol. 2013;382:400-12 pubmed publisher
    ..Taken together, our data suggest strongly that Vangl2 regulates FBM neuron migration by acting in floor plate cells, independently of cilia function. ..
  9. Lin J, Pan H, Ma L, Shen Y, Schachner M. The cell neural adhesion molecule contactin-2 (TAG-1) is beneficial for functional recovery after spinal cord injury in adult zebrafish. PLoS ONE. 2012;7:e52376 pubmed publisher
    ..The combined observations indicate that contactin-2 contributes to locomotor recovery and successful regrowth of axons after spinal cord injury in adult zebrafish. ..
  10. Stockinger P, Maître J, Heisenberg C. Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube. Development. 2011;138:4673-83 pubmed publisher
    ..By contrast, reducing cohesion among FBMNs by interfering with Contactin 2 (Cntn2) expression in these cells has little effect on apical FBMN movement, but reduces the fusion of the ..
  11. Hoffman E, Turner K, Fernández J, Cifuentes D, Ghosh M, Ijaz S, et al. Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 2016;89:725-33 pubmed publisher
    ..These results identify estrogenic compounds as phenotypic suppressors and illuminate novel pharmacological pathways with relevance to autism. ..
  12. Pittman A, Gaynes J, Chien C. nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system. Dev Biol. 2010;344:784-94 pubmed publisher
  13. Scholpp S, Brand M. Integrity of the midbrain region is required to maintain the diencephalic-mesencephalic boundary in zebrafish no isthmus/pax2.1 mutants. Dev Dyn. 2003;228:313-22 pubmed
    ..We therefore suggest that the genetic program controlled by Pax2.1 is not only involved in initiating but also in maintaining the identity of midbrain and isthmus cells to prevent them from assuming a forebrain or hindbrain fate. ..
  14. Chandrasekhar A, Warren J, Takahashi K, Schauerte H, van Eeden F, Haffter P, et al. Role of sonic hedgehog in branchiomotor neuron induction in zebrafish. Mech Dev. 1998;76:101-15 pubmed
    ..These results demonstrate that Shh is not solely responsible for inducing branchiomotor and spinal motor neurons, and suggest that Shh and Twhh may function as partially redundant signals for motor neuron induction in zebrafish. ..
  15. Nevin L, Xiao T, Staub W, Baier H. Topoisomerase IIbeta is required for lamina-specific targeting of retinal ganglion cell axons and dendrites. Development. 2011;138:2457-65 pubmed publisher
    ..The noto mutant provides the first example of the importance of an epigenetic regulator, Top2b, in the intricate series of events that lead to a properly wired visual system. ..
  16. Bingham S, Toussaint G, Chandrasekhar A. Neuronal development and migration in zebrafish hindbrain explants. J Neurosci Methods. 2005;149:42-9 pubmed
    ..These results suggest that hindbrain explant culture can be employed effectively in zebrafish to analyze neuronal migration and other dynamic processes using pharmacological and imaging techniques. ..