cldne

Summary

Gene Symbol: cldne
Description: claudin e
Alias: cb84, fb16e12, wu:fb16e12, claudin-4
Species: zebrafish

Top Publications

  1. Siddiqui M, Sheikh H, Tran C, Bruce A. The tight junction component Claudin E is required for zebrafish epiboly. Dev Dyn. 2010;239:715-22 pubmed publisher
    ..Here, we focus on the function of Claudin E (Cldne), which is expressed specifically in the EVL...
  2. Clelland E, Kelly S. Tight junction proteins in zebrafish ovarian follicles: stage specific mRNA abundance and response to 17beta-estradiol, human chorionic gonadotropin, and maturation inducing hormone. Gen Comp Endocrinol. 2010;168:388-400 pubmed publisher
    ..The data supports a role for the endocrine regulation of TJ proteins in ovarian follicle development. ..
  3. Schwend T, Loucks E, Snyder D, Ahlgren S. Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish. J Lipid Res. 2011;52:1328-44 pubmed publisher
    ..Collectively, these studies show that npc1 is required early for proper cell movement and cholesterol localization and later for cell survival. ..
  4. Day K, Jagadeeswaran P. Microarray analysis of prothrombin knockdown in zebrafish. Blood Cells Mol Dis. 2009;43:202-10 pubmed publisher
    ..The identification of these genes regulated by thrombin according to microarray analysis should provide a greater understanding of the effects of thrombin activity in the early vertebrate embryo. ..
  5. Fu B, Chen M, Zou M, Long M, He S. The rapid generation of chimerical genes expanding protein diversity in zebrafish. BMC Genomics. 2010;11:657 pubmed publisher
    ..Our results indicate that retroposition created a large amount of new genes in the zebrafish genome, which has contributed significantly to the evolution of the fish genome. ..
  6. Harvey S, Sealy I, Kettleborough R, FĂ©nyes F, White R, STEMPLE D, et al. Identification of the zebrafish maternal and paternal transcriptomes. Development. 2013;140:2703-10 pubmed publisher
  7. Kumari P, Gilligan P, Lim S, Tran L, Winkler S, Philp R, et al. An essential role for maternal control of Nodal signaling. elife. 2013;2:e00683 pubmed publisher
    ..Thus, Ybx1 prevents ectopic Nodal activity, revealing a new paradigm in the regulation of Nodal signaling, which is likely to be conserved. DOI:http://dx.doi.org/10.7554/eLife.00683.001. ..
  8. Liu H, Leslie E, Jia Z, Smith T, Eshete M, Butali A, et al. Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate. Hum Mol Genet. 2016;25:766-76 pubmed publisher
    ..These results indicate that rare NSCL/P risk variants can be found in members of the gene regulatory network governing periderm differentiation. ..
  9. Li E, Truong D, Hallett S, Mukherjee K, Schutte B, Liao E. Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model. PLoS Genet. 2017;13:e1007009 pubmed publisher
    ..Furthermore, it unlocked the possibility for characterizing yet undiscovered human IRF6 missense gene variants from orofacial cleft patients, and illustrated a generalizable functional genomics paradigm in personalized medicine. ..

More Information

Publications12

  1. Loh Y, Christoffels A, Brenner S, Hunziker W, Venkatesh B. Extensive expansion of the claudin gene family in the teleost fish, Fugu rubripes. Genome Res. 2004;14:1248-57 pubmed
  2. Reischauer S, Levesque M, NUSSLEIN VOLHARD C, Sonawane M. Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genet. 2009;5:e1000720 pubmed publisher
    ..Our data reveal that pen/lgl2 functions as a tumor suppressor gene in vertebrates, establishing zebrafish pen/lgl2 mutants as a valuable cancer model. ..
  3. Kumai Y, Bahubeshi A, Steele S, Perry S. Strategies for maintaining Na? balance in zebrafish (Danio rerio) during prolonged exposure to acidic water. Comp Biochem Physiol A Mol Integr Physiol. 2011;160:52-62 pubmed publisher
    ..These results demonstrate that in acidic water, zebrafish maintain their whole body Na? balance primarily by regulating Na? uptake, rather than Na? efflux. ..