Gene Symbol: ckma
Description: creatine kinase, muscle a
Alias: CK-M, cb51, ckm, mck, wu:fa28d05, muscle creatine kinase a
Species: zebrafish
Products:     ckma

Top Publications

  1. Yang J, Wang J, Zeng Z, Qiao L, Zhuang L, Jiang L, et al. Smad4 is required for the development of cardiac and skeletal muscle in zebrafish. Differentiation. 2016;92:161-168 pubmed publisher
    ..and vmhc, as well as abnormal expression of three makers of myogenic terminal differentiation, mylz2, smyhc1 and mck. Furthermore, a notable increase in apoptosis was apparent in the smad4 knockdown embryos, while no obvious ..
  2. Tee J, Sartori da Silva M, Rygiel A, Muncan V, Bink R, van den Brink G, et al. asb11 is a regulator of embryonic and adult regenerative myogenesis. Stem Cells Dev. 2012;21:3091-103 pubmed publisher
    ..Hence, we provide evidence that d-asb11 is a principal regulator of embryonic as well as adult regenerative myogenesis. ..
  3. Parolini M, Bini L, Magni S, Rizzo A, Ghilardi A, Landi C, et al. Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environ Pollut. 2018;232:603-614 pubmed publisher
    ..Our data confirmed the potential toxicity of low concentrations of COC, BE and EME, and helped to shed light on their MoA on an aquatic vertebrate during early developmental period. ..
  4. Chen K, Cole R, Rees B. Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. J Proteomics. 2013;78:477-85 pubmed publisher
    ..These proteomic changes may contribute to the acclimation of zebrafish to hypoxia, thereby increasing their tolerance of low oxygen concentrations. ..
  5. Gao Y, Wang Y, Li C, Chen Z, Yan Y, Zhou H. Dissecting the key residues crucial for the species-specific thermostability of muscle-type creatine kinase. Int J Biol Macromol. 2010;47:366-70 pubmed publisher
    ..The results showed that two residues close to the dimer interface of MMCK, the 46th and 146th residue, were crucial for species-specific thermal stability. ..
  6. Delgado Olguin P, Brand Arzamendi K, Scott I, Jungblut B, Stainier D, Bruneau B, et al. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011;286:12483-94 pubmed publisher
    ..We conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis. ..
  7. Cortelazzo A, Pietri T, De Felice C, Leoncini S, Guerranti R, Signorini C, et al. Proteomic analysis of the Rett syndrome experimental model mecp2Q63X mutant zebrafish. J Proteomics. 2017;154:128-133 pubmed publisher
    ..This non-mammalian vertebrate model of RTT strongly suggests a broad impact of Mecp2 dysfunction. ..
  8. Bosworth C, Chou C, Cole R, Rees B. Protein expression patterns in zebrafish skeletal muscle: initial characterization and the effects of hypoxic exposure. Proteomics. 2005;5:1362-71 pubmed
    ..The difference between protein and mRNA expression illustrates the need to integrate both measures for a more complete understanding of gene expression in fish during hypoxic exposure. ..
  9. Fujii T, Tsunesumi S, Sagara H, Munakata M, Hisaki Y, Sekiya T, et al. Smyd5 plays pivotal roles in both primitive and definitive hematopoiesis during zebrafish embryogenesis. Sci Rep. 2016;6:29157 pubmed publisher
    ..As the expression of myeloid markers was elevated in smyd5 loss-of-function zebrafish, we propose that Smyd5 plays critical roles in hematopoiesis. ..

More Information


  1. Almeida D, Bianchini A, Marins L. Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions. Gen Comp Endocrinol. 2013;194:102-9 pubmed publisher
    ..At the gene expression level, transgenesis increased lactate dehydrogenase (LDH) and creatine kinase muscle (CKM) expression in fish under normoxic conditions...
  2. Gómez Requeni P, Conceição L, Olderbakk Jordal A, Rønnestad I. A reference growth curve for nutritional experiments in zebrafish (Danio rerio) and changes in whole body proteome during development. Fish Physiol Biochem. 2010;36:1199-215 pubmed publisher
    ..Thus, in order to design nutritional studies with zebrafish fed Artemia nauplii, it is recommended to select a period between 20 and 40 dpf, when fish allocate most of the ingested energy for non-reproductive growth purposes. ..
  3. Harder G, McGowan R. Isolation and characterization of the muscle-specific isoform of creatine kinase from the zebrafish, Danio rerio. Biochem Cell Biol. 2001;79:779-82 pubmed
    ..The sequence is very similar to muscle-specific creatine kinases isolated from other species at both the nucleotide and amino acid levels but contains some differences from a previously reported zebrafish clone. ..
  4. Li J, Yue Y, Dong X, Jia W, Li K, Liang D, et al. Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly. J Biol Chem. 2015;290:10216-28 pubmed publisher
    ..Taken together, our results demonstrate that foxc1a plays an essential role in early somitogenesis by controlling Fgf and Notch signaling through restricting the expression of aldh1a2 in paraxial mesoderm directly. ..
  5. Amali A, Lin C, Chen Y, Wang W, Gong H, Lee C, et al. Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1. Dev Dyn. 2004;229:847-56 pubmed
    ..of MRFs, MSP, and IGFs in the knock-down embryos by RT-PCR revealed the up-regulation of MyoD, Myogenin, and Mck transcription, whereas IGF-2 transcription showed mild response with no effect on IGF-1, Desmin, and Myf5...
  6. Langenau D, Keefe M, Storer N, Guyon J, Kutok J, Le X, et al. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev. 2007;21:1382-95 pubmed
    ..When coupled with gene expression studies of this cell population, we propose that the zebrafish RMS cancer stem cell shares similar self-renewal programs as those found in activated satellite cells...
  7. Guan B, Ma H, Wang Y, Hu Y, Lin Z, Zhu Z, et al. Vitreoscilla hemoglobin (VHb) overexpression increases hypoxia tolerance in zebrafish (Danio rerio). Mar Biotechnol (NY). 2011;13:336-44 pubmed publisher
    ..These results suggest that that vhb gene may be an efficient candidate for genetically modifying hypoxia tolerance in fish. ..
  8. Yang J, Zeng Z, Wei J, Jiang L, Ma Q, Wu M, et al. Sema4d is required for the development of the hindbrain boundary and skeletal muscle in zebrafish. Biochem Biophys Res Commun. 2013;433:213-9 pubmed publisher
    ..Collectively, these data suggest that sema4d plays an important role in the development of the hindbrain and skeletal muscle. ..
  9. Ding L, Zang L, Zhang Y, Zhang Y, Wang X, Ai W, et al. Joint toxicity of fluoroquinolone and tetracycline antibiotics to zebrafish (Danio rerio) based on biochemical biomarkers and histopathological observation. J Toxicol Sci. 2017;42:267-280 pubmed publisher
    ..05) up-regulated in all treatments after two months of DKA exposure. CKma expression from skeletal muscle was significantly down-regulated in the 90 mg/L treatment...
  10. Zhuo H, Huang L, Huang H, Cai Z. Effects of chronic tramadol exposure on the zebrafish brain: a proteomic study. J Proteomics. 2012;75:3351-64 pubmed publisher
    ..Ultrastructural observation of mitochondria showed a series of morphological changes in the case of TH exposure. ..
  11. Wu C, Lin T, Chang T, Sun H, Hui C, Wu J. Zebrafish HSC70 promoter to express carp muscle-specific creatine kinase for acclimation under cold condition. Transgenic Res. 2011;20:1217-26 pubmed publisher
    ..The swimming distance of the transgenic fish was 42% greater than that of the wild type at 13°C. This new transgenic fish model is ideal for studies of ectothermal vertebrates in low-temperature environments. ..
  12. Doğanlı C, Beck H, Ribera A, Oxvig C, Lykke Hartmann K. ?3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish. J Biol Chem. 2013;288:8862-74 pubmed publisher
    ..Our data thus strongly support the role of ?3Na(+)/K(+)-ATPase in zebrafish motility and brain development, associating for the first time the ?3Na(+)/K(+)-ATPase deficiency with brain ventricle dilation. ..
  13. Fujii T, Tsunesumi S, Yamaguchi K, Watanabe S, Furukawa Y. Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish. PLoS ONE. 2011;6:e23491 pubmed publisher
    ..These data suggest that Smyd3 plays an important role in the development of heart and skeletal muscle. ..