Gene Symbol: chuk
Description: conserved helix-loop-helix ubiquitous kinase
Alias: ikk1, zgc:56539, inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase 1, IKK-A, IKK-alpha, IKKa, NFKBIKA, i kappa-B kinase alpha, ikBKA, ikappaB kinase, nuclear factor NF-kappa-B inhibitor kinase alpha, pky
Encinas P, Garcia Valtanen P, Chinchilla B, Gomez Casado E, Estepa A, Coll J. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. PLoS ONE. 2013;8:e73553 pubmed publisher
..These results could contribute to develop novel drug-based prevention methods and consolidate the zebrafish/SVCV as a model for vertebrate viral diseases. ..
Fukazawa C, Santiago C, Park K, Deery W, Gomez de la Torre Canny S, Holterhoff C, et al
. poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis. Dev Biol. 2010;346:272-83 pubmed publisher
..Differentiation of the EVL requires the maternal effect gene poky/ikk1 in EVL cells prior to establishment of the basal layer...
Correa R, Matsui T, Tergaonkar V, Rodriguez Esteban C, Izpisua Belmonte J, Verma I. Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity. Curr Biol. 2005;15:1291-5 pubmed
The IkappaB kinase (IKK) activity is critical for processing IkappaB inhibitory proteins and activating the NF-kappaB signaling, which is involved in a series of physiological and developmental steps in vertebrates...
Maddirevula S, Anuppalle M, Huh T, Kim S, Rhee M. Rnf11-like is a novel component of NF-?B signaling, governing the posterior patterning in the zebrafish embryos. Biochem Biophys Res Commun. 2012;422:602-6 pubmed publisher
..causes cell death and developmental defects in the posterior somites, elevating transcripts of NF-?B target gene, ikk1, a negative regulator of NF-?B signaling...
Magliozzi R, Low T, Weijts B, Cheng T, Spanjaard E, Mohammed S, et al
. Control of epithelial cell migration and invasion by the IKK?- and CK1?-mediated degradation of RAPGEF2. Dev Cell. 2013;27:574-85 pubmed publisher
..These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKK? and cell motility controlled by Rap-integrin signaling...
Li L, Huang T, Tian C, Xiao Y, Kou S, Zhou X, et al
. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-?B pathway in zebrafish embryos. Life Sci. 2016;157:97-106 pubmed publisher
..Moreover, the PHE also ameliorated the ROS-mediated inflammatory response. ..
Lisse T, Rieger S. IKK? regulates human keratinocyte migration through surveillance of the redox environment. J Cell Sci. 2017;130:975-988 pubmed publisher
..migration, we analyzed oxidation of a candidate upstream target, the inhibitor of ?B kinase ? (IKK?; encoded by CHUK), as a mechanism of action...
Díaz Pascual F, Ortíz Severín J, Varas M, Allende M, Chavez F. In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae. Front Cell Infect Microbiol. 2017;7:334 pubmed publisher
..aeruginosa. Our global proteomic profiling identifies novel molecular signatures that give systematic insight into zebrafish-Pseudomonas interaction. ..