chsy1

Summary

Gene Symbol: chsy1
Description: chondroitin sulfate synthase 1
Alias: chys1, wu:fc27h05, wu:fc27h06, zgc:64191, chondroitin sulfate synthase 1, carbohydrate (chondroitin) synthase 1
Species: zebrafish
Products:     chsy1

Top Publications

  1. Peal D, Burns C, Macrae C, Milan D. Chondroitin sulfate expression is required for cardiac atrioventricular canal formation. Dev Dyn. 2009;238:3103-10 pubmed publisher
  2. Tian J, Ling L, Shboul M, Lee H, O CONNOR B, Merriman B, et al. Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling. Am J Hum Genet. 2010;87:768-78 pubmed publisher
    ..High-throughput sequencing of all 177 candidate genes detected a truncating frameshift mutation in the gene CHSY1 encoding a chondroitin synthase with a Fringe domain...
  3. Li Y, Laue K, Temtamy S, Aglan M, Kotan L, Yigit G, et al. Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling. Am J Hum Genet. 2010;87:757-67 pubmed publisher
    ..Here we identify chondroitin synthase 1 (CHSY1) as a potential mediator of BMP effects...
  4. Holmborn K, Habicher J, Kasza Z, Eriksson A, Filipek Gorniok B, Gopal S, et al. On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. J Biol Chem. 2012;287:33905-16 pubmed
  5. Filipek Gorniok B, Holmborn K, Haitina T, Habicher J, Oliveira M, Hellgren C, et al. Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development. Dev Dyn. 2013;242:964-75 pubmed publisher
    ..genome, chpfa and chpfb, while the other five human CS/DS glycosyltransferases csgalnact1, csgalnact2, chpf2, chsy1, and chsy3 all have single zebrafish orthologues...