Gene Symbol: chrng
Description: cholinergic receptor, nicotinic, gamma
Alias: chrngl, wu:fc54e06, acetylcholine receptor subunit gamma, AChr gamma, cholinergic receptor, nicotinic, gamma like, nicotinic acetylcholine receptor subunit gamma
Species: zebrafish

Top Publications

  1. Etard C, Behra M, Ertzer R, Fischer N, Jesuthasan S, Blader P, et al. Mutation in the delta-subunit of the nAChR suppresses the muscle defects caused by lack of Dystrophin. Dev Dyn. 2005;234:1016-25 pubmed
    ..The myofiber detachment phenotype of Dystroglycan-deficient embryos was not suppressed, suggesting that Dystrophin and Dystroglycan play distinct roles in muscle formation and maintenance of muscle integrity. ..
  2. Mongeon R, Walogorsky M, Urban J, Mandel G, Ono F, Brehm P. An acetylcholine receptor lacking both ? and ? subunits mediates transmission in zebrafish slow muscle synapses. J Gen Physiol. 2011;138:353-66 pubmed publisher
    ..The unique functional features offered by the ?(2)??(2) receptor likely play a central role in mediating the persistent contractions characteristic to this muscle type. ..
  3. Papke R, Ono F, Stokes C, Urban J, Boyd R. The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study. Biochem Pharmacol. 2012;84:352-65 pubmed publisher
    ..Our data therefore indicate that while some pharmacological tools used in zebrafish may function as expected, others will not. ..
  4. Menelaou E, Udvadia A, Tanguay R, Svoboda K. Activation of ?2A-containing nicotinic acetylcholine receptors mediates nicotine-induced motor output in embryonic zebrafish. Eur J Neurosci. 2014;40:2225-40 pubmed publisher
    ..These findings also indicate that functional neuronal nAChRs are present within spinal cord at the time when locomotor output in zebrafish first begins to manifest itself. ..
  5. Park J, Mott M, Williams T, Ikeda H, Wen H, Linhoff M, et al. A single mutation in the acetylcholine receptor ?-subunit causes distinct effects in two types of neuromuscular synapses. J Neurosci. 2014;34:10211-8 pubmed publisher
    ..Both wild-type and mutant larvae lacked ?/? subunits in slow muscle synapses. These findings in zebrafish suggest that some mutations in human congenital myasthenic syndromes may affect slow and fast muscle fibers differently. ..
  6. Ahmed K, Ali D. Nicotinic acetylcholine receptors (nAChRs) at zebrafish red and white muscle show different properties during development. Dev Neurobiol. 2016;76:916-36 pubmed publisher
    ..2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 916-936, 2016. ..