chrd

Summary

Gene Symbol: chrd
Description: chordin
Alias: chd, din, fe47d04, wu:fe47d04, chordin, chordino, dino (din), protein chordino
Species: zebrafish

Top Publications

  1. Muraoka O, Shimizu T, Yabe T, Nojima H, Bae Y, Hashimoto H, et al. Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Nat Cell Biol. 2006;8:329-38 pubmed
    ..We found that Sizzled stabilizes Chordin, a Bmp antagonist, by binding and inhibiting the Tolloid-family metalloproteinase, Bmp1a, which cleaves and ..
  2. Esterberg R, Fritz A. dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity. Dev Biol. 2009;325:189-99 pubmed publisher
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction. ..
  3. Tribulo C, Aybar M, Nguyen V, Mullins M, Mayor R. Regulation of Msx genes by a Bmp gradient is essential for neural crest specification. Development. 2003;130:6441-52 pubmed publisher
    ..We propose a model where a gradient of Bmp activity specifies the expression of Msx genes in the neural folds, and that this expression is essential for the early specification of the neural crest...
  4. Carreira Barbosa F, Concha M, Takeuchi M, Ueno N, Wilson S, Tada M. Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development. 2003;130:4037-46 pubmed
    ..In addition, Pk1 interacts with Tri to mediate posterior migration of branchiomotor neurons, probably independent of the noncanonical Wnt pathway. ..
  5. Blader P, Rastegar S, Fischer N, Strahle U. Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid. Science. 1997;278:1937-40 pubmed
    ..embryos overexpressing a zebrafish homolog of tolloid were shown to resemble loss-of-function mutations in chordino, the zebrafish homolog of the Xenopus BMP-4 antagonist Chordin...
  6. Rentzsch F, Zhang J, Kramer C, Sebald W, Hammerschmidt M. Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation. Development. 2006;133:801-11 pubmed
    ..Although structurally related to the Bmp antagonist Chordin, Crossveinless 2 has been described to be both a Bmp agonist and antagonist...
  7. Kudoh T, Concha M, Houart C, Dawid I, Wilson S. Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. Development. 2004;131:3581-92 pubmed
    ..We further show that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity promotes the adoption of caudal fate by this tissue. ..
  8. Liu X, Xiong C, Jia S, Zhang Y, Chen Y, Wang Q, et al. Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nat Commun. 2013;4:1728 pubmed publisher
    ..Our findings open avenues for investigating the potential significance of Raf regulation of transforming growth factor ? signalling in versatile biological and pathological processes in the future. ..
  9. Varga M, Maegawa S, Bellipanni G, Weinberg E. Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo. Mech Dev. 2007;124:775-91 pubmed
    ..b>chordin expression during zebrafish gastrulation has been previously shown in both axial and paraxial domains, but is ..

More Information

Publications72

  1. Ho C, Houart C, Wilson S, Stainier D. A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene. Curr Biol. 1999;9:1131-4 pubmed
    ..repressor and its overexpression led to the downregulation of bmp2b and wnt8 expression and the expansion of chordin expression...
  2. Zhang Y, Li X, Qi J, Wang J, Liu X, Zhang H, et al. Rock2 controls TGFbeta signaling and inhibits mesoderm induction in zebrafish embryos. J Cell Sci. 2009;122:2197-207 pubmed publisher
    ..Thus, our data have unraveled previously unidentified functions of Rock2, in controlling TGFbeta signaling as well as in regulating embryonic patterning. ..
  3. Wagner D, Mullins M. Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev Biol. 2002;245:109-23 pubmed
    ..and mini fin/tolloid were each analyzed in double mutant combinations with the ventralized mutants chordino/chordin and ogon, whose molecular nature is not known...
  4. von der Hardt S, Bakkers J, Inbal A, Carvalho L, Solnica Krezel L, Heisenberg C, et al. The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr Biol. 2007;17:475-87 pubmed
  5. Lyman Gingerich J, Westfall T, Slusarski D, Pelegri F. hecate, a zebrafish maternal effect gene, affects dorsal organizer induction and intracellular calcium transient frequency. Dev Biol. 2005;286:427-39 pubmed
  6. Ober E, Schulte Merker S. Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafish. Dev Biol. 1999;215:167-81 pubmed
    ..In addition, these experiments show that the establishment of the anteroposterior axis is independent of the dorsoventral axis. ..
  7. Xie J, Fisher S. Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms. Development. 2005;132:383-91 pubmed
    BMP signaling is modulated by a number of extracellular proteins, including the inhibitor Chordin, Tolloid-related enzymes (Tld), and the interacting protein Twisted Gastrulation (Tsg)...
  8. Nguyen V, Trout J, Connors S, Andermann P, Weinberg E, Mullins M. Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development. 2000;127:1209-20 pubmed
  9. Connors S, Tucker J, Mullins M. Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues. Dev Biol. 2006;293:191-202 pubmed
    ..is positively regulated by Tolloid, a metalloprotease, that can eliminate the activity of the BMP antagonist Chordin. A tolloid mutant in zebrafish, mini fin (mfn), exhibits a specific loss of ventral tail tissues...
  10. Shih Y, Kuo C, Hirst C, Dee C, Liu Y, Laghari Z, et al. SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling. Development. 2010;137:2671-81 pubmed publisher
    ..It therefore seems that the broad expression of these SoxB1 genes throughout the early epiblast and their subsequent restriction to the ectoderm is a primary regulator of when and where the organizer forms. ..
  11. Ro H, Dawid I. Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. Nat Cell Biol. 2009;11:1121-7 pubmed publisher
    ..These studies introduce a ubiquitin ligase, Lnx-l, as a balancing modulator of axial patterning in the zebrafish embryo. ..
  12. Ramel M, Lekven A. Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. Development. 2004;131:3991-4000 pubmed
    ..Thus, whereas both Wnt8 and zygotic BMP are ventralizing agents that regulate common target genes, their temporally different modes of action are necessary to pattern the embryo harmoniously along its DV axis. ..
  13. Shimizu T, Yamanaka Y, Nojima H, Yabe T, Hibi M, Hirano T. A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Mech Dev. 2002;118:125-38 pubmed
    ..These results suggest that ved is a target for the repressor Dha/Boz. Ved functions redundantly with vox/vega1 and vent/vega2 to restrict the organizer domain. ..
  14. Sirotkin H, Dougan S, Schier A, Talbot W. bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm in zebrafish. Development. 2000;127:2583-92 pubmed
    ..Expression of chordin and noggin1 is greatly reduced in boz;sqt mutants, indicating that the boz and sqt pathways have overlapping ..
  15. Koos D, Ho R. The nieuwkoid gene characterizes and mediates a Nieuwkoop-center-like activity in the zebrafish. Curr Biol. 1998;8:1199-206 pubmed
  16. Tay H, Ng Y, Manser E. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS ONE. 2010;5:e10125 pubmed publisher
    ..These events may mirror the requirement for PAK2 signaling essential for the proper formation of the blood-brain barrier. ..
  17. Yin C, Kikuchi K, Hochgreb T, Poss K, Stainier D. Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Dev Cell. 2010;18:973-84 pubmed publisher
    ..Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM remodeling during organogenesis. ..
  18. Flores M, Lam E, Crosier K, Crosier P. Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish. Nat Cell Biol. 2008;10:346-52 pubmed publisher
  19. Feng Q, Zou X, Lu L, Li Y, Liu Y, Zhou J, et al. The stress-response gene redd1 regulates dorsoventral patterning by antagonizing Wnt/?-catenin activity in zebrafish. PLoS ONE. 2012;7:e52674 pubmed publisher
    ..These findings have unraveled a novel role of Redd1 in early development by antagonizing Wnt/?-catenin signaling. ..
  20. Ramel M, Buckles G, Baker K, Lekven A. WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. Dev Biol. 2005;287:237-48 pubmed
  21. Leung A, Mendenhall E, Kwan T, Liang R, Eckfeldt C, Chen E, et al. Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev Biol. 2005;277:235-54 pubmed
    We investigated the mechanisms of intermediate cell mass (ICM) expansion in zebrafish chordin (Chd) morphant embryos and examined the role of BMPs in relation to this phenotype...
  22. Pelegri F, Maischein H. Function of zebrafish beta-catenin and TCF-3 in dorsoventral patterning. Mech Dev. 1998;77:63-74 pubmed
  23. Baker K, Ramel M, Lekven A. A direct role for Wnt8 in ventrolateral mesoderm patterning. Dev Dyn. 2010;239:2828-36 pubmed publisher
    ..approach in the zebrafish to generate embryos lacking expression of both Wnt8 and the BMP antagonist Chordin. wnt8;chordin loss-of-function embryos show rescued BMP signaling, thereby allowing us to identify Wnt8-specific ..
  24. Maegawa S, Varga M, Weinberg E. FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer. Development. 2006;133:3265-76 pubmed
    ..to test for the epistatic relationship between beta-catenin activation, FGF signaling and bozozok, squint and chordin expression. Injection of beta-catenin RNA into ichabod embryos can completely rescue normal development...
  25. Zhang Y, Lander A, Nie Q. Computational analysis of BMP gradients in dorsal-ventral patterning of the zebrafish embryo. J Theor Biol. 2007;248:579-89 pubmed
    ..suggest that the DV patterning of vertebrates is controlled by a similar network of BMPs and antagonists (such as Chordin, a homologue of Sog), but differences exist in how the two systems are organized, and a quantitative comparison ..
  26. Miller Bertoglio V, Carmany Rampey A, F├╝rthauer M, Gonzalez E, Thisse C, Thisse B, et al. Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. Dev Biol. 1999;214:72-86 pubmed
    ..protein (BMP) activity, which, in part, arises through the interaction of dorsally expressed antagonists Chordin and Noggin with the ventralizing BMPs...
  27. Londin E, Niemiec J, Sirotkin H. Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction. Dev Biol. 2005;279:1-19 pubmed
    ..The extracellular BMP antagonist Chordin and other signals from the dorsal mesoderm play important roles in this process...
  28. Shimizu T, Bae Y, Muraoka O, Hibi M. Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev Biol. 2005;279:125-41 pubmed
    ..These data indicate that the cdx genes mediate Wnt signaling and play essential roles in the morphogenesis of the posterior body in zebrafish. ..
  29. Little S, Mullins M. Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development. 2004;131:5825-35 pubmed
    ..Moreover, loss of tsg1 partially suppressed the ventralized phenotypes of mutants of the BMP antagonists Chordin or Sizzled (Ogon)...
  30. Grinblat Y, Gamse J, Patel M, Sive H. Determination of the zebrafish forebrain: induction and patterning. Development. 1998;125:4403-16 pubmed
    ..either the presumptive prechordal plate, marked by goosecoid (gsc) expression, or the entire organizer, marked by chordin (chd) expression...
  31. Tse W, You M, Ho S, Jiang Y. The deubiquitylating enzyme Cops6 regulates different developmental processes during early zebrafish embryogenesis. Int J Dev Biol. 2011;55:19-24 pubmed publisher
    ..Overall, the present study that consolidates our previous work on zebrafish DUB genes, corroborates the hypothesis of multi-functional roles for DUB genes during development. ..
  32. Fekany Lee K, Gonzalez E, Miller Bertoglio V, Solnica Krezel L. The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways. Development. 2000;127:2333-45 pubmed
    ..The neural induction defect was correlated with decreased chordino expression and consequent increases in bmp2b/4 expression, and was suppressed by overexpression of BMP ..
  33. Jia S, Wu D, Xing C, Meng A. Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish. Dev Biol. 2009;333:273-84 pubmed publisher
    ..Knockdown of chordin partially inhibits effect of smad3b overexpression on neural induction, implying that Smad2/3 exert their effect ..
  34. Willot V, Mathieu J, Lu Y, Schmid B, Sidi S, Yan Y, et al. Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. Dev Biol. 2002;241:59-78 pubmed
    ..This is shown by partial rescue of the dorsalized mutant snailhouse and of the ventralized mutant chordino, upon admp and tr-admp RNA injection, respectively...
  35. Branam A, Hoffman G, Pelegri F, Greenspan D. Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis. Dev Biol. 2010;341:444-58 pubmed publisher
    b>Chordin is the prototype of a group of cysteine-rich domain-containing proteins that bind and modulate signaling of various TGFbeta-like ligands...
  36. Tsang M, Maegawa S, Kiang A, Habas R, Weinberg E, Dawid I. A role for MKP3 in axial patterning of the zebrafish embryo. Development. 2004;131:2769-79 pubmed
    ..Thus, mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which is initiated at an early stage so as to ensure correct FGF signaling levels at the time of axial patterning. ..
  37. Tucker J, Mintzer K, Mullins M. The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. Dev Cell. 2008;14:108-19 pubmed publisher
    ..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously. ..
  38. Imai Y, Gates M, Melby A, Kimelman D, Schier A, Talbot W. The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. Development. 2001;128:2407-20 pubmed
    ..Expression of dorsal mesodermal genes, including chordin, goosecoid and bozozok, is strongly expanded in embryos that lack vox and vent function, indicating that the ..
  39. Kramer C, Mayr T, Nowak M, Schumacher J, Runke G, Bauer H, et al. Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. Dev Biol. 2002;250:263-79 pubmed
    ..This indicates that maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2/7 signaling to establish the initial dorsoventral asymmetry. ..
  40. Gerdes J, Liu Y, Zaghloul N, Leitch C, Lawson S, Kato M, et al. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet. 2007;39:1350-60 pubmed
  41. Westfall T, Hjertos B, Slusarski D. Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning. Dev Biol. 2003;259:380-91 pubmed
    ..These results provide evidence that modulation of calcium release is critical for early embryonic patterning and acts by influencing the stabilization of beta-catenin protein. ..
  42. Hashiguchi M, Mullins M. Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development. 2013;140:1970-80 pubmed publisher
    ..Thus, DV and AP patterning are intimately coordinated to allow cells to acquire both positional and temporal information simultaneously. ..
  43. Ramel M, Hill C. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol. 2013;378:170-82 pubmed publisher
  44. Dick A, Hild M, Bauer H, Imai Y, Maifeld H, Schier A, et al. Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo. Development. 2000;127:343-54 pubmed
    ..mRNA injection studies and double mutant analyses indicate that Bmp2b and Bmp7 closely cooperate and that Bmp2b/Bmp7 signaling is transduced by Smad5 and antagonized by Chordino.
  45. Gritsman K, Zhang J, Cheng S, Heckscher E, Talbot W, Schier A. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. Cell. 1999;97:121-32 pubmed
    ..Expression of the murine EGF-CFC gene cripto rescues oep mutants. These results suggest a conserved role for EGF-CFC proteins as essential extracellular cofactors for Nodal signaling during vertebrate development. ..
  46. Row R, Kimelman D. Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud. Dev Biol. 2009;329:55-63 pubmed publisher
  47. Van Raay T, Coffey R, Solnica Krezel L. Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol. 2007;309:151-68 pubmed
    ..Finally, reducing Nkd1 function in slb mutants suppressed the axial mesendoderm C&E defect. These data indicate that zebrafish Nkd1 and Nkd2 function to limit both canonical and non-canonical Wnt signaling. ..
  48. Jasuja R, Voss N, Ge G, Hoffman G, Lyman Gingerich J, Pelegri F, et al. bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Mech Dev. 2006;123:548-58 pubmed
    ..two of which, BMP1 and mammalian Tolloid-like 1 (mTLL1), are responsible for cleaving the SOG orthologue Chordin, thereby regulating signaling by DPP orthologues BMP2 and 4...
  49. Westfall T, Brimeyer R, Twedt J, Gladon J, Olberding A, Furutani Seiki M, et al. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol. 2003;162:889-98 pubmed
    ..The Wnt-5 loss-of-function defect is consistent with Ca2+ modulation having an antagonistic interaction with Wnt/beta-catenin signaling. ..
  50. Dal Pra S, F├╝rthauer M, Van Celst J, Thisse B, Thisse C. Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Dev Biol. 2006;298:514-26 pubmed
    ..by the bone morphogenetic proteins (Bmp) activity arising through interaction with antagonists such as Noggin, Chordin and Follistatin...
  51. Krens S, He S, Lamers G, Meijer A, Bakkers J, Schmidt T, et al. Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Dev Biol. 2008;319:370-83 pubmed publisher
    ..Together, our data define distinct roles for ERK1 and ERK2 in developmental cell migration processes during zebrafish embryogenesis. ..
  52. Dixon Fox M, Bruce A. Short- and long-range functions of Goosecoid in zebrafish axis formation are independent of Chordin, Noggin 1 and Follistatin-like 1b. Development. 2009;136:1675-85 pubmed publisher
    ..In striking contrast to Xenopus, the BMP inhibitor Chordin (Chd) is not required for Gsc function...
  53. Jopling C, van Geemen D, den Hertog J. Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. PLoS Genet. 2007;3:e225 pubmed
    ..The finding that defective Shp2 signaling induced cell movement defects as early as gastrulation may have implications for the monitoring and diagnosis of Noonan and LEOPARD syndrome...
  54. Nojima H, Shimizu T, Kim C, Yabe T, Bae Y, Muraoka O, et al. Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. Mech Dev. 2004;121:371-86 pubmed
    ..Inhibition of cytoplasmic calcium release elicited an ectopic and expanded expression of chordin in the wild-type, but did not restore chordin expression efficiently in the tkk embryos...
  55. Bellipanni G, Varga M, Maegawa S, Imai Y, Kelly C, Myers A, et al. Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm. Development. 2006;133:1299-309 pubmed
    ..We propose that the early, dorsal-promoting function of beta-catenin-2 is essential to counteract a later, dorsal- and neurectoderm-repressing function that is shared by both beta-catenin genes...
  56. Patterson S, Bird N, Devoto S. BMP regulation of myogenesis in zebrafish. Dev Dyn. 2010;239:806-17 pubmed publisher
    ..In addition, we show that while BMP overexpression is sufficient to delay myogenic differentiation, inhibition of BMP does not detectably affect this process, suggesting that other factors redundantly inhibit myogenic differentiation. ..
  57. Fisher S, Halpern M. Patterning the zebrafish axial skeleton requires early chordin function. Nat Genet. 1999;23:442-6 pubmed
    ..More dorsally, the organizer region counteracts BMP signalling through secretion of BMP-binding antagonists chordin and noggin, allowing dorsally derived tissues such as neurectoderm and somitic muscle to develop...
  58. Shimizu T, Yabe T, Muraoka O, Yonemura S, Aramaki S, Hatta K, et al. E-cadherin is required for gastrulation cell movements in zebrafish. Mech Dev. 2005;122:747-63 pubmed
    ..These data suggest that E-cadherin-mediated cell adhesion between the DC and EVL plays a role in the epiboly movement in zebrafish. ..
  59. Cao Y, Zhao J, Sun Z, Zhao Z, Postlethwait J, Meng A. fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Dev Biol. 2004;271:130-43 pubmed
    ..Overexpression of fgf17b dorsalizes zebrafish gastrulae by enhancing expression of chordin (chd), which is an antagonist of the ventralizing signals BMPs...
  60. Zhong Y, Lu L, Zhou J, Li Y, Liu Y, Clemmons D, et al. IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos. J Cell Sci. 2011;124:1925-35 pubmed publisher
    ..In vivo expression of Igfbp3 increased chordin expression in zebrafish embryos by alleviating the negative regulation of Bmp2...
  61. Hashimoto H, Itoh M, Yamanaka Y, Yamashita S, Shimizu T, Solnica Krezel L, et al. Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Dev Biol. 2000;217:138-52 pubmed
    ..These data indicate that Dkk1, expressed in dorsal mesendoderm, functions in the formation of both the anterior nervous system and the axial mesendoderm in zebrafish. ..
  62. Mei W, Lee K, Marlow F, Miller A, Mullins M. hnRNP I is required to generate the Ca2+ signal that causes egg activation in zebrafish. Development. 2009;136:3007-17 pubmed publisher
    ..Our studies therefore reveal an important new role of hnrnp I in regulating the fundamental process of IP(3)-mediated Ca(2+) release at egg activation. ..
  63. Jopling C, Hertog J. Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation. Mech Dev. 2007;124:129-36 pubmed
    ..The Csk knock down phenotype was rescued by simultaneous partial knock down of Fyn and Yes. We conclude that Csk acts upstream of Fyn and Yes to control vertebrate gastrulation cell movements. ..