cga

Summary

Gene Symbol: cga
Description: glycoprotein hormones, alpha polypeptide
Alias: GPHa, GTH-alpha, gsu-alpha, glycoprotein hormones alpha chain, gonadotropin alpha subunit
Species: zebrafish
Products:     cga

Top Publications

  1. Li X, He J, Hu W, Yin Z. The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 2009;150:2767-74 pubmed publisher
    ..Our research here has demonstrated that zebrafish is a unique model for functional studies of endogenous ghrelin, especially during embryonic development. ..
  2. Nica G, Herzog W, Sonntag C, Nowak M, Schwarz H, Zapata A, et al. Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis. Dev Biol. 2006;292:189-204 pubmed
    ..Eya1 is required for lineage-specific differentiation of adenohypophyseal cells, but not for their survival, thereby uncoupling the differentiation-promoting and anti-apoptotic effects of Eya proteins seen in other tissues. ..
  3. Pogoda H, von der Hardt S, Herzog W, Kramer C, Schwarz H, Hammerschmidt M. The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis. Development. 2006;133:1079-89 pubmed
    ..Together, this suggests that Ascl1a might act downstream of diencephalic Fgf3 signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis...
  4. Nica G, Herzog W, Sonntag C, Hammerschmidt M. Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism. Mol Endocrinol. 2004;18:1196-209 pubmed
    ..In sum, our data point to both conserved and class-specific aspects of Pit1 function during pituitary development in different vertebrate species. ..
  5. Huang W, Hsieh J, Chiou M, Chen J, Wu J, Kuo C. Application of RNAi technology to the inhibition of zebrafish GtHalpha, FSHbeta, and LHbeta expression and to functional analyses. Zoolog Sci. 2008;25:614-21 pubmed publisher
    ..Taken together, these results show that GtHalpha-shRNA, which more efficiently targets RNAi, may have an essential role in the further development of sterility technology of transgenic fish for biosafety purposes. ..
  6. Liu Y, Wang J, Fang X, Zhang H, Dai J. The thyroid-disrupting effects of long-term perfluorononanoate exposure on zebrafish (Danio rerio). Ecotoxicology. 2011;20:47-55 pubmed publisher
    ..Our results provide the first evidence for the thyroid-disrupting effects of long-term PFNA exposure in zebrafish. ..
  7. Dutta S, Dietrich J, Westerfield M, Varga Z. Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary. Dev Biol. 2008;319:248-57 pubmed publisher
    ..We propose that Notch mediated lateral inhibition regulates the relative numbers of specified hormone cell types in the three pituitary subdomains. ..
  8. Guner B, Ozacar A, Thomas J, Karlstrom R. Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis. Endocrinology. 2008;149:4435-51 pubmed publisher
    ..These data suggest that there are distinct origins and signaling requirements for the PD and PI. ..
  9. Wong A, Van Eenennaam A. Gonadotropin hormone and receptor sequences from model teleost species. Zebrafish. 2004;1:203-21 pubmed publisher
    ..The gonadotropin alpha-subunit (Cga) is highly conserved among teleosts and tetrapods...

More Information

Publications21

  1. Graf M, Teo Qi Wen E, Sarusie M, Rajaei F, Winkler C. Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary. Mol Endocrinol. 2015;29:187-99 pubmed publisher
    ..Intriguingly, its effect on gonadotrope numbers defines a first nongonadal role for a dmrt family member that appears crucial for the activity of the reproductive system. ..
  2. Kwok H, So W, Wang Y, Ge W. Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors--evidence for their distinct functions in follicle development. Biol Reprod. 2005;72:1370-81 pubmed
    ..These results suggest differential roles for Fshr and Lhr in zebrafish ovarian follicle development. ..
  3. Chen W, Ge W. Ontogenic expression profiles of gonadotropins (fshb and lhb) and growth hormone (gh) during sexual differentiation and puberty onset in female zebrafish. Biol Reprod. 2012;86:73 pubmed publisher
    ..However, the significance of the location change of Fsh cells during this period will be interesting to investigate. ..
  4. Quiroz Y, Lopez M, Mavropoulos A, Motte P, Martial J, Hammerschmidt M, et al. The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish. Mol Endocrinol. 2012;26:1014-27 pubmed publisher
  5. Cheng X, Chen X, Jin X, He J, Yin Z. Generation and characterization of gsu?:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. Toxicol Appl Pharmacol. 2014;278:78-84 pubmed publisher
    ..These reporter fish can serve as a novel platform to perform screenings of endocrine-disrupting chemicals (EDCs) in vivo as well. ..
  6. Cheng X, Chen X, Li D, Jin X, He J, Yin Z. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. Gen Comp Endocrinol. 2015;214:87-94 pubmed publisher
    ..Our current results raised the cautions to the intensively application of MTZ in clinical practices and biomedical researches. ..
  7. Chen W, Lau S, Fan Y, Wu R, Ge W. Juvenile exposure to bisphenol A promotes ovarian differentiation but suppresses its growth - Potential involvement of pituitary follicle-stimulating hormone. Aquat Toxicol. 2017;193:111-121 pubmed publisher
    ..Our data in the zebrafish suggest that sex differentiation involves estrogens and it is a sensitive window for evaluating estrogenic activities of compounds and their impacts on wildlife reproduction...
  8. Dickmeis T, Lahiri K, Nica G, Vallone D, Santoriello C, Neumann C, et al. Glucocorticoids play a key role in circadian cell cycle rhythms. PLoS Biol. 2007;5:e78 pubmed
    ..Instead, they act in concert with a systemic signaling environment of which glucocorticoids are an essential part. ..
  9. Li Y, Tsoi S, Mannen H, Shoei Lung Li S. Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. J Mol Evol. 2002;54:614-24 pubmed
    ..Other gene duplication events were also discovered in Xenopus, the first duplication occurring approximately 60-70 mya in both Ldh-A and Ldh-B, followed by another recent gene duplication event, approximately 20 mya, in Ldh-B. ..
  10. Yu X, Lin S, Kobayashi M, Ge W. Expression of recombinant zebrafish follicle-stimulating hormone (FSH) in methylotropic yeast Pichia pastoris. Fish Physiol Biochem. 2010;36:273-81 pubmed publisher
    ..One form (zfFSH) was produced as the molecule closer to the native form, with the two subunits (Cga and Fshb) expressed separately under different promoters...
  11. So W, Kwok H, Ge W. Zebrafish gonadotropins and their receptors: II. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone subunits--their spatial-temporal expression patterns and receptor specificity. Biol Reprod. 2005;72:1382-96 pubmed
    ..In the present study, we cloned and characterized zebrafish FSHbeta (fshb), LHbeta (lhb), and GTHalpha (cga) subunits...
  12. Spicer O, Wong T, Zmora N, Zohar Y. Targeted Mutagenesis of the Hypophysiotropic Gnrh3 in Zebrafish (Danio rerio) Reveals No Effects on Reproductive Performance. PLoS ONE. 2016;11:e0158141 pubmed publisher
    ..However, other than changes in mRNA levels of pituitary gonadotropin genes (fshb, lhb, and cga) during early development, which are corrected by adulthood, there were no changes in ontogeny and reproduction in ..