Gene Symbol: cflara
Description: CASP8 and FADD-like apoptosis regulator a
Alias: Clarp1, FLIP, cflar, CASP8 and FADD-like apoptosis regulator a
Inohara N, Koseki T, Hu Y, Chen S, Nunez G. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Proc Natl Acad Sci U S A. 1997;94:10717-22 pubmed
..The human clarp gene maps to 2q33. Thus, CLARP represents a regulator of the upstream caspase-8, which may play a role in apoptosis during tissue development and homeostasis. ..
Inohara N, Nunez G. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ. 2000;7:509-10 pubmed
Santoro M, Samuel T, Mitchell T, Reed J, Stainier D. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet. 2007;39:1397-402 pubmed
Rodriguez Aznar E, Nieto M. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. Cell Death Differ. 2011;18:1196-207 pubmed publisher
..Our data indicate that the regulatory loop linking p53/Puma with Scratch is active in the vertebrate nervous system, not only controlling cell death in response to damage but also during normal embryonic development. ..
Zhang D, Golubkov V, Han W, Correa R, Zhou Y, Lee S, et al
. Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival. Dev Biol. 2014;395:96-110 pubmed publisher
..A role for Anxa4 in cell survival may have implications for the mechanism of diabetic ÃŸ-cell apoptosis and cancer cell chemoresistance. ..
Zhou Z, Sun L. Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Front Cell Infect Microbiol. 2016;6:76 pubmed publisher
..tarda prevents apoptosis in teleost as a strategy for intracellular survival, and that some putative apoptotic genes of teleost function in the apoptosis pathway probably in a manner similar to that in mammalian systems. ..
Sakamaki K, Iwabe N, Iwata H, Imai K, Takagi C, Chiba K, et al
. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Biochem Biophys Rep. 2015;3:175-189 pubmed publisher
Cellular FLICE-like inhibitory protein (c-FLIP, gene symbol CFLAR) was first identified as a negative regulator of death receptor-mediated apoptosis in mammals...