cerkl

Summary

Gene Symbol: cerkl
Description: ceramide kinase-like
Alias: zgc:162213, ceramide kinase-like protein
Species: zebrafish
Products:     cerkl

Top Publications

  1. Riera M, Burguera D, Garcia Fern ndez J, Gonz lez Duarte R. CERKL knockdown causes retinal degeneration in zebrafish. PLoS ONE. 2013;8:e64048 pubmed publisher
    The human CERKL gene is responsible for common and severe forms of retinal dystrophies...
  2. Li C, Wang L, Zhang J, Huang M, Wong F, Liu X, et al. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014;1842:1121-9 pubmed publisher
    Mutations in the ceramide kinase-like gene (CERKL) are associated with severe retinal degeneration. However, the exact function of the encoded protein (CERKL) remains unknown...
  3. Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, et al. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017;26:2335-2345 pubmed publisher
    In humans, CERKL mutations cause widespread retinal degeneration: early dysfunction and loss of rod and cone photoreceptors in the outer retina and, progressively, death of cells in the inner retina...