Genomes and Genes
Gene Symbol: cebpb
Description: CCAAT enhancer binding protein beta
Alias: c/ebpb, cb380, fe11e05, wu:fe11e05, CCAAT/enhancer-binding protein beta, CCAAT/enhancer binding protein (C/EBP), beta
- Garcia Reyero N, Escalon B, Prats E, Stanley J, Thienpont B, Melby N, et al. Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health. Environ Int. 2014;63:216-23 pubmed publisher..Once accumulated, our data also show that BDE-209 has the potential to cause impacts on both human and environmental health. ..
- Shimada Y, Kuroyanagi J, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, et al. Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice. Int J Obes (Lond). 2014;38:1053-60 pubmed publisher..Integrated analysis of human and zebrafish transcriptomes allows identification of a novel therapeutic target against human obesity and further associated metabolic disease. ..
- Lam S, Lee S, Lin C, Thomsen J, Fu P, Murthy K, et al. Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. BMC Med Genomics. 2011;4:41 pubmed publisher..Our study provides first evidence of molecular conservation of estrogen-responsiveness between zebrafish and human cancer cell lines, hence demonstrating the potential of zebrafish for estrogen-related cancer research. ..
- Hall C, Flores M, Oehlers S, Sanderson L, Lam E, Crosier K, et al. Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide. Cell Stem Cell. 2012;10:198-209 pubmed publisher..These results provide new insights into the reactive capacity of HSPCs and how the blood system is "fine-tuned" in response to inflammatory stress. ..
- Hall C, Boyle R, Astin J, Flores M, Oehlers S, Sanderson L, et al. Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating ?-oxidation-dependent mitochondrial ROS production. Cell Metab. 2013;18:265-78 pubmed publisher..These results reveal IRG1 as a key component of the immunometabolism axis, connecting infection, cellular metabolism, and macrophage effector function...
- Amali A, Rekha R, Lin C, Wang W, Gong H, Her G, et al. Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. J Biomed Sci. 2006;13:225-32 pubmed..Moreover, non-availability of specific drugs to prevent steatohepatitis, this animal model may serve as a powerful preclinical platform to study the therapeutic strategies and for evaluating chemoprevention strategies for this disease...
- Wang Y, Lin C, Chuang M, Hsieh W, Lan C, Chuang Y, et al. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. BMC Syst Biol. 2013;7:79 pubmed publisher..With continued accumulation of interspecies transcriptomics data, the proposed method could be used to explore progressive network rewiring over time, which could benefit the development of network medicine for infectious diseases. ..
- Wang W, Hong J, Lin G, Liu W, Gong H, Lu M, et al. Stage-specific expression of TNF? regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells. PLoS ONE. 2011;6:e16740 pubmed publisher..i.). Taken together, our results indicate that IPNV triggers two death pathways via up-stream induction of the pro-inflammatory cytokine TNF?, and these results may provide new insights into the pathogenesis of RNA viruses. ..
- Sabel J, d Alençon C, O Brien E, Van Otterloo E, Lutz K, Cuykendall T, et al. Maternal Interferon Regulatory Factor 6 is required for the differentiation of primary superficial epithelia in Danio and Xenopus embryos. Dev Biol. 2009;325:249-62 pubmed publisher..These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio. This epithelium constitutes a novel model tissue in which to explore the Irf6 regulatory pathway. ..
- Mesquita S, van Drooge B, Oliveira E, Grimalt J, Barata C, Vieira N, et al. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environ Pollut. 2015;206:535-42 pubmed publisher..The observed effects can be directly related to air pollution-related human disorders, suggesting different potential adverse outcomes for human populations exposed to air pollution from specific sources. ..
- Eisinger A, Nadauld L, Shelton D, Peterson P, Phelps R, Chidester S, et al. The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. J Biol Chem. 2006;281:20474-82 pubmed
- Kenyon A, Gavriouchkina D, Zorman J, Napolitani G, Cerundolo V, Sauka Spengler T. Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Sci Rep. 2017;7:6505 pubmed publisher..Further perturbation of the IEGs exposes egr3 as a key transcriptional regulator controlling il1Î² transcription. ..
- Li E, Truong D, Hallett S, Mukherjee K, Schutte B, Liao E. Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model. PLoS Genet. 2017;13:e1007009 pubmed publisher..Furthermore, it unlocked the possibility for characterizing yet undiscovered human IRF6 missense gene variants from orofacial cleft patients, and illustrated a generalizable functional genomics paradigm in personalized medicine. ..
- Powell C, Elsaeidi F, Goldman D. Injury-dependent Müller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b. J Neurosci. 2012;32:1096-109 pubmed publisher..These data identify an essential role for Apobec proteins during retina and optic nerve regeneration and suggest DNA demethylation may underlie the reprogramming of cells to mount a regenerative response. ..
- Imrie D, Sadler K. White adipose tissue development in zebrafish is regulated by both developmental time and fish size. Dev Dyn. 2010;239:3013-23 pubmed publisher..6 mm standard length contained the adult repertoire of WAT depots. Pancreatic, esophageal, and subcutaneous WAT appearance correlated with size, not age, as found for other features appearing during postembryonic zebrafish development. ..
- Pfefferli C, Muller F, Jazwinska A, Wicky C. Specific NuRD components are required for fin regeneration in zebrafish. BMC Biol. 2014;12:30 pubmed publisher..These results provide in vivo evidence for the involvement of key epigenetic factors in the cellular reprogramming processes occurring during epimorphic regeneration in zebrafish. ..
- Minchin J, Dahlman I, Harvey C, Mejhert N, Singh M, Epstein J, et al. Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proc Natl Acad Sci U S A. 2015;112:4363-8 pubmed publisher..Together, our findings identify Plxnd1 as a novel regulator of VAT growth, body fat distribution, and insulin sensitivity in both zebrafish and humans. ..
- Ung C, Lam S, Hlaing M, Winata C, Korzh S, Mathavan S, et al. Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics. 2010;11:212 pubmed publisher..The molecular conservation of mercury-induced hepatotoxicity between zebrafish and human cell line reveals the feasibility of using zebrafish to model molecular toxicity in human for toxicant risk assessments. ..
- Huang C, Chen P, Huang C, Yu J. Aristolochic Acid induces heart failure in zebrafish embryos that is mediated by inflammation. Toxicol Sci. 2007;100:486-94 pubmed