cdk5

Summary

Gene Symbol: cdk5
Description: cyclin-dependent kinase 5
Alias: zgc:101604, cyclin-dependent-like kinase 5, cyclin-dependent protein kinase 5
Species: zebrafish
Products:     cdk5

Top Publications

  1. Kanungo J, Li B, Zheng Y, Pant H. Cyclin-dependent kinase 5 influences Rohon-Beard neuron survival in zebrafish. J Neurochem. 2006;99:251-9 pubmed
    Cyclin-dependent kinase 5 (cdk5), a member of the cyclin-dependent kinase family, is expressed predominantly in post-mitotic cell populations. Unlike the other cdks, cdk5 is abundant and most active in differentiated neurons...
  2. Kanungo J, Li B, Goswami M, Zheng Y, Ramchandran R, Pant H. Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5. Neurosci Lett. 2007;412:233-8 pubmed
    Cyclin-dependent kinase 5 (cdk5) is a ubiquitous protein activated by neuron-specific activators, p35 and p39. Cdk5 regulates neuronal migration, differentiation, axonogenesis, synaptic transmission and apoptosis...
  3. Leung Y, Ma P, Link B, Dowling J. Factorial microarray analysis of zebrafish retinal development. Proc Natl Acad Sci U S A. 2008;105:12909-14 pubmed publisher
    ..Biological significance was confirmed by further analysis of components of the Cdk5 signaling pathway and Irx transcription factor family, representing genes identified in category 1...
  4. Kanungo J, Zheng Y, Amin N, Kaur S, Ramchandran R, Pant H. Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo. Biochem Biophys Res Commun. 2009;386:263-7 pubmed publisher
    Cyclin-dependent kinase 5 (cdk5) is a ubiquitous protein activated by specific activators, p35 and p39. Cdk5 regulates neuronal migration, differentiation, axonogenesis, synaptic transmission and apoptosis...
  5. Groeneweg J, White Y, Kokel D, Peterson R, Zukerberg L, Berin I, et al. cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish. Mol Reprod Dev. 2011;78:22-32 pubmed publisher
    ..Lastly, marked reductions in p35, but not Cdk5, were observed in cables1 morphants...
  6. Tanaka H, Morimura R, Ohshima T. Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish. Dev Biol. 2012;370:223-36 pubmed publisher
    ..A similar phenotype was observed in the cdk5 and dyrk2 double morphants. Dpysl2 and Dpysl3 phosphorylation mimics recovered this phenotype...
  7. Kanungo J, Zheng Y, Mishra B, Pant H. Zebrafish Rohon-Beard neuron development: cdk5 in the midst. Neurochem Res. 2009;34:1129-37 pubmed publisher
    Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39...
  8. Zhang L, Li Y, Chen T, Xia W, Zhou Y, Wan Y, et al. Abnormal development of motor neurons in perfluorooctane sulphonate exposed zebrafish embryos. Ecotoxicology. 2011;20:643-52 pubmed publisher
    ..we examined the expression of alpha-tubulin, proliferating cell nuclear antigen (PCNA), cyclin-dependent kinase 5 (CDK5), and peroxiredoxin 2 (PRX2) after PFOS exposure until 120 hpf...
  9. Easley Neal C, Fierro J, Buchanan J, Washbourne P. Late recruitment of synapsin to nascent synapses is regulated by Cdk5. Cell Rep. 2013;3:1199-212 pubmed publisher
    ..Importantly, cyclin-dependent kinase 5 (Cdk5) specifically regulated the late recruitment of synapsin transport packets at synapses...

More Information

Publications11

  1. Morimura R, Nozawa K, Tanaka H, Ohshima T. Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord. Dev Neurobiol. 2013;73:911-20 pubmed publisher
    ..The knockdown of cdk5 and dyrk2 by AMO also caused similar phenotype in the positioning of CaP motor neurons, and this phenotype was ..
  2. Dimri M, Bilogan C, Pierce L, Naegele G, Vasanji A, Gibson I, et al. Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish. Development. 2017;144:2595-2605 pubmed publisher
    ..Utilizing the algorithm, we showed that inhibition of Cyclin-dependent kinase 5 (Cdk5) led to reduced branching in the intrahepatic biliary network in zebrafish...