cd8a

Summary

Gene Symbol: cd8a
Description: CD8a molecule
Alias: zgc:136643, CD8a molecule, CD8 alpha, CD8 antigen, alpha polypeptide
Species: zebrafish

Top Publications

  1. Takizawa F, Araki K, Ito K, Moritomo T, Nakanishi T. Expression analysis of two Eomesodermin homologues in zebrafish lymphoid tissues and cells. Mol Immunol. 2007;44:2324-31 pubmed
    ..These results suggest that both Eomes genes are involved in the zebrafish immune response, particularly in lymphocyte function as has been found in mammals. ..
  2. Liu X, Wu H, Liu Q, Wang Q, Xiao J, Chang X, et al. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2015;45:342-5 pubmed publisher
  3. Wan F, Hu C, Ma J, Gao K, Xiang L, Shao J. Characterization of ?? T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Front Immunol. 2016;7:675 pubmed publisher
    ..It is anticipated that this study would be used as a guide to develop a zebrafish model for the cross-species investigation of ?? T cell biology. ..
  4. Somamoto T, Yoshiura Y, Nakanishi T, Ototake M. Molecular cloning and characterization of two types of CD8alpha from ginbuna crucian carp, Carassius auratus langsdorfii. Dev Comp Immunol. 2005;29:693-702 pubmed
    ..These results suggest that expression analysis of these two gbCD8alpha sequences provides a useful tool to address the involvement of cytotoxic T-lymphocytes during the cell-meditated immune response in fish. ..
  5. Gao Y, Wu H, Wang Q, Qu J, Liu Q, Xiao J, et al. A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 2014;32:5937-44 pubmed publisher
    ..In summary, a combination vaccine of live attenuated E. tarda WED and V. anguillarum MVAV6203 is effective and could be used widely in the future. ..
  6. Pereiro P, Varela M, Diaz Rosales P, Romero A, Dios S, Figueras A, et al. Zebrafish Nk-lysins: First insights about their cellular and functional diversification. Dev Comp Immunol. 2015;51:148-59 pubmed publisher
    ..Moreover, only two of these genes (nkla and nkld) were significantly up-regulated after viral infection, and this observation could be also a consequence of a functional diversification of the zebrafish Nk-lysins. ..
  7. Sun Z, Shen B, Wu H, Zhou X, Wang Q, Xiao J, et al. The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Fish Shellfish Immunol. 2015;46:638-47 pubmed publisher
    ..Taken together, our results suggest that FBA can be utilized as a broad-spectrum vaccine against various pathogenic bacteria of aquaculture in the future. ..
  8. Liu X, Xu J, Zhang H, Liu Q, Xiao J, Zhang Y. Design and evaluation of an Edwardsiella tarda DNA vaccine co-encoding antigenic and adjuvant peptide. Fish Shellfish Immunol. 2016;59:189-195 pubmed publisher
    ..These results suggest that co-encoding antigenic and adjuvant proteins might be an efficient strategy to develop DNA vaccines in aquaculture in the future. ..
  9. Garcia Valtanen P, Martínez López A, López Muñoz A, Bello Perez M, Medina Gali R, Ortega Villaizan M, et al. Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Front Immunol. 2017;8:121 pubmed publisher
    ..From this and other studies, it might be concluded that some of the characteristics of mammalian trained immunity are present in lower vertebrates. ..

More Information

Publications16

  1. Zhang M, Wu H, Li X, Yang M, Chen T, Wang Q, et al. Edwardsiella tarda flagellar protein FlgD: a protective immunogen against edwardsiellosis. Vaccine. 2012;30:3849-56 pubmed publisher
    ..tarda. ..
  2. Kavaliauskis A, Arnemo M, Kim S, Ulanova L, Speth M, Novoa B, et al. Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 2015;12:421-31 pubmed publisher
    ..Our results show that poly(I:C) is a promising candidate as an adjuvant for fish vaccination against viral pathogens, and that the zebrafish is a promising model for aquaculture-relevant vaccination studies. ..
  3. Kavaliauskis A, Arnemo M, Speth M, Lagos L, Rishovd A, Estepa A, et al. Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Dev Comp Immunol. 2016;61:248-57 pubmed publisher
    ..Our results suggest that chitosan-poly(I:C) NPs are a promising adjuvant candidate for future vaccine formulations. ..
  4. Dee C, Nagaraju R, Athanasiadis E, Gray C, Fernandez Del Ama L, Johnston S, et al. CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. J Immunol. 2016;197:3520-3530 pubmed
  5. Sugimoto K, Hui S, Sheng D, Nakayama M, Kikuchi K. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Dev Comp Immunol. 2017;73:156-162 pubmed publisher
  6. Yang D, Liu Q, Ni C, Li S, Wu H, Wang Q, et al. Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: insights into the basic mechanisms of protection seen in immunized fish. Dev Comp Immunol. 2013;40:132-41 pubmed publisher
    ..This mechanism involved the induction of the TLR-5 signaling pathway, the MHC-I antigen processing pathway and CTL effector function, and CTL function seems play a major role in the protection against E. tarda infection in zebrafish. ..
  7. Varela M, Forn Cuní G, Dios S, Figueras A, Novoa B. Proinflammatory Caspase A Activation and an Antiviral State Are Induced by a Zebrafish Perforin after Possible Cellular and Functional Diversification from a Myeloid Ancestor. J Innate Immun. 2016;8:43-56 pubmed publisher
    ..In particular, one of the genes, prf19b, which is mainly produced by myeloid cells, seemed to be involved in antiviral defense, conferring protection after an in vivo infection. ..