Gene Symbol: cd74a
Description: CD74 molecule, major histocompatibility complex, class II invariant chain a
Alias: Iclp-1, iclp1, wu:fb11f09, wu:fb12a01, wu:fb13d06, wu:fk94e07, CD74 molecule, major histocompatibility complex, class II invariant chain a, MHC II, invariant chain-like protein 1
Lugo Villarino G, Balla K, Stachura D, Banuelos K, Werneck M, Traver D. Identification of dendritic antigen-presenting cells in the zebrafish. Proc Natl Acad Sci U S A. 2010;107:15850-5 pubmed publisher
..of genes associated with DC function and antigen presentation, including il12, MHC class II invariant chain iclp1, and csf1r. Importantly, we show that PNA(hi) cells can activate T lymphocytes in an antigen-dependent manner...
Shen Y, Thompson D, Kuah M, Wong K, Wu K, Linn S, et al
. The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. Dev Biol. 2012;363:84-94 pubmed publisher
Shao T, Zhu L, Nie L, Shi W, Dong W, Xiang L, et al
. Characterization of surface phenotypic molecules of teleost dendritic cells. Dev Comp Immunol. 2015;49:38-43 pubmed publisher
..Our findings contributed to the current understanding of the evolutionary history of DCs and the DC-regulatory mechanisms of adaptive immunity. ..
Serbanovic Canic J, De Luca A, Warboys C, Ferreira P, Luong L, Hsiao S, et al
. Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arterioscler Thromb Vasc Biol. 2017;37:130-143 pubmed publisher
Lin A, Xiang L, Wang Q, Dong W, Gong Y, Shao J. The DC-SIGN of zebrafish: insights into the existence of a CD209 homologue in a lower vertebrate and its involvement in adaptive immunity. J Immunol. 2009;183:7398-410 pubmed publisher
..We hope that the present study will contribute to a better cross-species understanding of the evolutionary history of the DC-SIGN/CD209 family. ..
Garcia Valtanen P, Martinez Lopez A, Ortega Villaizan M, Perez L, Coll J, Estepa A. In addition to its antiviral and immunomodulatory properties, the zebrafish ?-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Res. 2014;101:136-47 pubmed publisher
..To note that psoriasis can be induced in zebrafish and the over-expression of ?-defensin 2 is implicated in the inflammatory response associated with this human skin disorder. ..
Xu H, Liu E, Li Y, Li X, Ding C. Transcriptome Analysis Reveals Increases in Visceral Lipogenesis and Storage and Activation of the Antigen Processing and Presentation Pathway during the Mouth-Opening Stage in Zebrafish Larvae. Int J Mol Sci. 2017;18: pubmed publisher
..The findings of this study are important for understanding the physiological switches during the mouth-opening stage. ..