Gene Symbol: cd40lg
Description: CD40 ligand
Alias: CD40 ligand, CD154, TNFSF5
Lin A, Xiang L, Wang Q, Dong W, Gong Y, Shao J. The DC-SIGN of zebrafish: insights into the existence of a CD209 homologue in a lower vertebrate and its involvement in adaptive immunity. J Immunol. 2009;183:7398-410 pubmed publisher
..We hope that the present study will contribute to a better cross-species understanding of the evolutionary history of the DC-SIGN/CD209 family. ..
Xu X, Hu J, Ma J, Nie L, Shao T, Xiang L, et al
. Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model. J Immunol. 2016;196:1686-99 pubmed publisher
..This study enriches the current knowledge on TIM-mediated immunity and provides a cross-species understanding of the evolutionary history of costimulatory systems throughout vertebrate evolution. ..
Gong Y, Xiang L, Shao J. CD154-CD40 interactions are essential for thymus-dependent antibody production in zebrafish: insights into the origin of costimulatory pathway in helper T cell-regulated adaptive immunity in early vertebrates. J Immunol. 2009;182:7749-62 pubmed publisher
The CD154-CD40-mediated costimulatory pathway is critical for T-B cell cooperation in thymus-dependent (TD) immune response in mammals. However, little is known about its existence and occurrence in lower vertebrates...
Wan F, Hu C, Ma J, Gao K, Xiang L, Shao J. Characterization of ?? T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Front Immunol. 2016;7:675 pubmed publisher
..It is anticipated that this study would be used as a guide to develop a zebrafish model for the cross-species investigation of ?? T cell biology. ..