Gene Symbol: cd40
Description: CD40 molecule, TNF receptor superfamily member 5
Alias: si:ch211-231h20.3, CD40 molecule, TNF receptor superfamily member 5, CD40 antigen, TNFR superfamily member 5, tnfsrf5
Wiens G, Glenney G. Origin and evolution of TNF and TNF receptor superfamilies. Dev Comp Immunol. 2011;35:1324-35 pubmed publisher
..The increasing interest and use of TNFSF and TNFRSF modulators in human and animal medicine underscores the need to understand the evolutionary origins as well as conserved and novel functions of these biologically important molecules. ..
Page D, Wittamer V, Bertrand J, Lewis K, Pratt D, Delgado N, et al
. An evolutionarily conserved program of B-cell development and activation in zebrafish. Blood. 2013;122:e1-11 pubmed publisher
..The IgM1:eGFP reporter fish are the first nonmammalian B-cell reporter animals to be described. They will be important for further investigation of immune cell evolution and development and host-pathogen interactions in zebrafish...
Tandberg J, Lagos L, Langlete P, Berger E, Rishovd A, Roos N, et al
. Comparative Analysis of Membrane Vesicles from Three Piscirickettsia salmonis Isolates Reveals Differences in Vesicle Characteristics. PLoS ONE. 2016;11:e0165099 pubmed publisher
..salmonis derived MVs, highlighting strain-specific vesicle characteristics. The results further illustrate that the MV proteome from one bacterial strain is not representative of all bacterial strains within one species. ..
Gong Y, Xiang L, Shao J. CD154-CD40 interactions are essential for thymus-dependent antibody production in zebrafish: insights into the origin of costimulatory pathway in helper T cell-regulated adaptive immunity in early vertebrates. J Immunol. 2009;182:7749-62 pubmed publisher
The CD154-CD40-mediated costimulatory pathway is critical for T-B cell cooperation in thymus-dependent (TD) immune response in mammals. However, little is known about its existence and occurrence in lower vertebrates...
Xiong R, Nie L, Xiang L, Shao J. Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution. J Immunol. 2012;188:2653-68 pubmed publisher
..It presents valuable clues for improving the understanding of not only the negative regulation of cytokine signaling in fish but also the evolutionary history of the PIAS family from fish to mammals as a whole. ..
Zhu L, Pan P, Fang W, Shao J, Xiang L. Essential role of IL-4 and IL-4R? interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates. J Immunol. 2012;188:5571-84 pubmed publisher
..The DrIL-4-DrIL-4R? interaction promoted CD40 expression on B cells and enhanced the CD154-CD40 costimulatory response, both of which are crucial for the ..
Wan F, Hu C, Ma J, Gao K, Xiang L, Shao J. Characterization of ?? T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Front Immunol. 2016;7:675 pubmed publisher
..It is anticipated that this study would be used as a guide to develop a zebrafish model for the cross-species investigation of ?? T cell biology. ..
Tandberg J, Oliver C, Lagos L, Gaarder M, Yañez A, Ropstad E, et al
. Membrane vesicles from Piscirickettsia salmonis induce protective immunity and reduce development of salmonid rickettsial septicemia in an adult zebrafish model. Fish Shellfish Immunol. 2017;67:189-198 pubmed publisher
..1, tnf?, il1b, il10 and il6. The MVs induced the secretion of IgM upon immunization, indicating an immunogenic effect of the vesicles. Taken together, the data demonstrate a vaccine potential of MVs against P. salmonis. ..
Lagos L, Tandberg J, Becker M, Winther Larsen H. Immunomodulatory properties of Concholepas concholepas hemocyanin against francisellosis in a zebrafish model. Fish Shellfish Immunol. 2017;67:571-574 pubmed publisher
..Taken together, the data report the immunoregulatory properties of CCH and its potential use as a vaccine adjuvant for aquaculture. ..