Gene Symbol: cd4-1
Description: CD4-1 molecule
Alias: CD4-3, CD4L-1, cd4, cd4-4, CD4-1 molecule, CD4 molecule
Yang D, Liu Q, Ni C, Li S, Wu H, Wang Q, et al
. Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: insights into the basic mechanisms of protection seen in immunized fish. Dev Comp Immunol. 2013;40:132-41 pubmed publisher
..In contrast, the MHC-II antigen processing pathway and the markers of CD4(+) T lymphocyte activation were down-regulated, and IgM transcription and specific IgM antibody titers were not ..
Sun Z, Shen B, Wu H, Zhou X, Wang Q, Xiao J, et al
. The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Fish Shellfish Immunol. 2015;46:638-47 pubmed publisher
..Taken together, our results suggest that FBA can be utilized as a broad-spectrum vaccine against various pathogenic bacteria of aquaculture in the future. ..
Wan F, Hu C, Ma J, Gao K, Xiang L, Shao J. Characterization of ?? T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Front Immunol. 2016;7:675 pubmed publisher
..They possess typical morphological features of lymphocytes with a surface phenotype of ?+?+CD4-CD8+...
Zhang M, Wu H, Li X, Yang M, Chen T, Wang Q, et al
. Edwardsiella tarda flagellar protein FlgD: a protective immunogen against edwardsiellosis. Vaccine. 2012;30:3849-56 pubmed publisher
Gao Y, Wu H, Wang Q, Qu J, Liu Q, Xiao J, et al
. A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 2014;32:5937-44 pubmed publisher
..In summary, a combination vaccine of live attenuated E. tarda WED and V. anguillarum MVAV6203 is effective and could be used widely in the future. ..
Pereiro P, Varela M, Diaz Rosales P, Romero A, Dios S, Figueras A, et al
. Zebrafish Nk-lysins: First insights about their cellular and functional diversification. Dev Comp Immunol. 2015;51:148-59 pubmed publisher
..Moreover, only two of these genes (nkla and nkld) were significantly up-regulated after viral infection, and this observation could be also a consequence of a functional diversification of the zebrafish Nk-lysins. ..
Liu X, Wu H, Liu Q, Wang Q, Xiao J, Chang X, et al
. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2015;45:342-5 pubmed publisher
Dee C, Nagaraju R, Athanasiadis E, Gray C, Fernandez Del Ama L, Johnston S, et al
. CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. J Immunol. 2016;197:3520-3530 pubmed
b>CD4+ T cells are at the nexus of the innate and adaptive arms of the immune system...
Garcia Valtanen P, Martínez López A, López Muñoz A, Bello Perez M, Medina Gali R, Ortega Villaizan M, et al
. Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Front Immunol. 2017;8:121 pubmed publisher
..From this and other studies, it might be concluded that some of the characteristics of mammalian trained immunity are present in lower vertebrates. ..