ccne2

Summary

Gene Symbol: ccne2
Description: cyclin E2
Alias: cb165, sb:cb165, zgc:86724, G1/S-specific cyclin-E2
Species: zebrafish

Top Publications

  1. Yuan B, Wang X, Fan C, You J, Liu Y, Weber J, et al. DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle. Mol Cell Biol. 2016;36:2903-2917 pubmed
  2. Shkumatava A, Neumann C. Shh directs cell-cycle exit by activating p57Kip2 in the zebrafish retina. EMBO Rep. 2005;6:563-9 pubmed
    ..These findings raise the possibility that stimulation of cell-cycle exit through regulation of core cell-cycle components may be part of a general mechanism required for Hh-directed differentiation. ..
  3. Shepard J, Amatruda J, Stern H, Subramanian A, Finkelstein D, Ziai J, et al. A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A. 2005;102:13194-9 pubmed
    ..Our findings show that zebrafish screens can uncover cancer pathways, and demonstrate that loss of function of bmyb is associated with cancer. ..
  4. Berndt J, Halloran M. Semaphorin 3d promotes cell proliferation and neural crest cell development downstream of TCF in the zebrafish hindbrain. Development. 2006;133:3983-92 pubmed
    ..Finally, Sema3d overexpression rescues reduced proliferation caused by DeltaTCF expression, suggesting that Sema3d lies downstream of Wnt/TCF signaling in the molecular pathway thought to control cell cycle in NCC precursors. ..
  5. Hu J, Sun S, Jiang Q, Sun S, Wang W, Gui Y, et al. Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Int J Biol Sci. 2013;9:267-78 pubmed publisher
    ..In conclusion, our results revealed that zebrafish yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis. ..
  6. Zhai G, Song J, Shu T, Yan J, Jin X, He J, et al. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. J Genet Genomics. 2017;44:307-317 pubmed publisher
    ..These data provide evidence for the crosstalk between the PC/LRH-1 and Wnt/β-catenin signaling pathways during the expansion growth of endoderm organs. ..
  7. Shkumatava A, Fischer S, Muller F, Strahle U, Neumann C. Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina. Development. 2004;131:3849-58 pubmed
    ..By performing mosaic analysis, we demonstrate that Shh directs these events as a short-range signal within the neural retina. ..
  8. Stadler J, Shkumatava A, Norton W, Rau M, Geisler R, Fischer S, et al. Histone deacetylase 1 is required for cell cycle exit and differentiation in the zebrafish retina. Dev Dyn. 2005;233:883-9 pubmed
    ..These results demonstrate that the in vivo role of HDAC1 in regulating cell cycle progression is region-specific, as HDAC1 promotes cell cycle exit in the retina but stimulates proliferation in other cellular contexts. ..
  9. Koltowska K, Apitz H, Stamataki D, Hirst E, Verkade H, Salecker I, et al. Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Development. 2013;140:1912-8 pubmed publisher

More Information

Publications11

  1. Crippa S, Nemir M, Ounzain S, Ibberson M, Berthonneche C, Sarre A, et al. Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Cardiovasc Res. 2016;110:73-84 pubmed publisher
    ..This novel strategy identifies a series of miRNAs and associated pathways, in particular miR-26a, which represent attractive therapeutic targets for inducing repair in the injured heart. ..
  2. Zhao X, Zhao L, Tian T, Zhang Y, Tong J, Zheng X, et al. Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish. J Biol Chem. 2010;285:27924-34 pubmed publisher
    ..Taken together, our findings uncover an essential role of cenph in mitosis and embryonic development and its association with tumor development. ..