Gene Symbol: cat
Description: catalase
Alias: fb68a12, wu:fb68a12, catalase
Species: zebrafish
Products:     cat

Top Publications

  1. Gerhard G, Kauffman E, Grundy M. Molecular cloning and sequence analysis of the Danio rerio catalase gene. Comp Biochem Physiol B Biochem Mol Biol. 2000;127:447-57 pubmed
    b>Catalase is an antioxidant enzyme that plays a central role in the protection against oxidative stress through the metabolism of hydrogen peroxide...
  2. Ken C, Lin C, Wu J, Shaw J. Cloning and expression of a cDNA coding for catalase from zebrafish (Danio rerio). J Agric Food Chem. 2000;48:2092-6 pubmed
    A full-length complementary DNA (cDNA) clone encoding a catalase was amplified by the rapid amplication of cDNA ends-polymerase chain reaction (RACE-PCR) technique from zebrafish (Danio rerio) mRNA...
  3. Chang C, Su Y, Her G, Ken C, Hong J. Betanodavirus induces oxidative stress-mediated cell death that prevented by anti-oxidants and zfcatalase in fish cells. PLoS ONE. 2011;6:e25853 pubmed publisher
    ..stage (24-48 h pi), this ROS signal may upregulate some expressions of the anti-oxidant enzymes Cu/Zn SOD and catalase, and eventually expression of the transcription factor Nrf2...
  4. Zhang J, Laurence Souders C, Denslow N, Martyniuk C. Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). Toxicol Appl Pharmacol. 2017;327:30-38 pubmed publisher transcripts related to apoptosis (bcl2, bax, casp3, casp7), but we did observe a decrease in mRNA levels for catalase (cat) in fish exposed to each dose, supporting an oxidative stress response...
  5. Dong X, Zhang Z, Meng S, Pan C, Yang M, Wu X, et al. Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity. Sci Total Environ. 2018;610-611:291-297 pubmed publisher
  6. Park C, Ji H, Kim S, Kil S, Lee J, Kwak S, et al. Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes. Int J Mol Med. 2017;39:960-968 pubmed publisher
    ..mediated at least in part by the restoration of the expression of PPAR???dependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1...
  7. Jin Y, Pan X, Cao L, Ma B, Fu Z. Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish Shellfish Immunol. 2013;34:717-23 pubmed publisher
    ..genes related to oxidative stress, apoptosis and immunotoxicity including Cu/Zn-superoxide dismutase (Cu/Zn-Sod), catalase (Cat), P53, murine double minute 2 (Mdm2), B-cell lymphoma/leukaemia-2 gene (Bcl2), Bcl2 associated X protein (..
  8. Jin Y, Zheng S, Pu Y, Shu L, Sun L, Liu W, et al. Cypermethrin has the potential to induce hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish (Danio rerio). Chemosphere. 2011;82:398-404 pubmed publisher
    ..Hepatic mRNA levels for the genes encoding antioxidant proteins, such as Cu/Zn-Sod, Mn-Sod, Cat, and Gpx, were significantly upregulated when zebrafish were exposed to various concentrations of CYP for 4 or 8 ..
  9. Zheng J, Yuan S, Wu C, Lv Z, Zhu A. Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish. Aquat Toxicol. 2017;182:113-119 pubmed publisher
    ..Taken together, oxidative stress and immunotoxicity in the brain were more serious when fish were exposed to Cd in the evening than in the morning, highlighting the importance of circadian rhythm in Cd-induced neurotoxicity in fish. ..

More Information


  1. Moussavi Nik S, Croft K, Mori T, Lardelli M. The comparison of methods for measuring oxidative stress in zebrafish brains. Zebrafish. 2014;11:248-54 pubmed publisher
    ..hydroperoxides did reveal significant changes in lipid peroxidation under these conditions, while analyses of catalase gene expression and an assay based on 2',7'-dicholorofluorescein oxidation also revealed changes in oxidative ..
  2. de Peralta M, Mouguelar V, Sdrigotti M, Ishiy F, Fanganiello R, Passos Bueno M, et al. Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes. Cell Death Dis. 2016;7:e2397 pubmed publisher
    ..Based on this, we suggest CNBP as an additional target for new alternative therapeutic treatments to reduce craniofacial defects not only in TCS but also in other neurocristopathies. ..
  3. Banni M, Chouchene L, Said K, Kerkeni A, Messaoudi I. Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafish Danio rerio. Biometals. 2011;24:981-92 pubmed publisher
    ..Cd exposure significantly inhibited the antioxidant enzyme activities termed as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) and caused a pronounced malondialdehyde (MDA) ..
  4. Cobbina S, Xu H, Zhao T, Mao G, Zhou Z, Wu X, et al. A multivariate assessment of innate immune-related gene expressions due to exposure to low concentration individual and mixtures of four kinds of heavy metals on zebrafish (Danio rerio) embryos. Fish Shellfish Immunol. 2015;47:1032-42 pubmed publisher
    ..Additionally, antioxidant genes were affected, as CAT and GPx gene expressions generally increased, whiles Mn-SOD and Zn/Cu-SOD reduced...
  5. Wu S, Shu L, Liu J, Chen C. Anti-oxidative Responses on Hepatic Tissue of Zebrafish (Danio rerio) in a Short Duration of Sub-lethal Concentrations of Cadmium Exposure. Bull Environ Contam Toxicol. 2017;98:612-618 pubmed publisher
    ..Antioxidants glutathione peroxidase (gpx1a), superoxide dismutase (sod), and catalase (cat) were up regulated after 1-3 h, and metallothionein isoforms (smtB and mt2) increased after 3-6 h of Cd<..
  6. Jaumot J, Navarro A, Faria M, Barata C, Tauler R, Piña B. qRT-PCR evaluation of the transcriptional response of zebra mussel to heavy metals. BMC Genomics. 2015;16:354 pubmed publisher
  7. Hou J, Li L, Xue T, Long M, Su Y, Wu N. Damage and recovery of the ovary in female zebrafish i.p.-injected with MC-LR. Aquat Toxicol. 2014;155:110-8 pubmed publisher
    ..MDA) contents as well as the enzymatic activities and transcriptional levels of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) showed the occurrence of oxidative stress, ..
  8. Wu S, Ji G, Liu J, Zhang S, Gong Y, Shi L. TBBPA induces developmental toxicity, oxidative stress, and apoptosis in embryos and zebrafish larvae (Danio rerio). Environ Toxicol. 2016;31:1241-9 pubmed publisher
    ..studies revealed that TBBPA did not alter the enzyme activities of Copper/Zinc Superoxide dismutase (Cu/Zn-SOD), catalase (CAT), and glutathioneperoxidase (GPx) at 0.10 mg/L, but decreased activities following exposure to 0.40, 0...
  9. Krysko O, Stevens M, Langenberg T, Fransen M, Espeel M, Baes M. Peroxisomes in zebrafish: distribution pattern and knockdown studies. Histochem Cell Biol. 2010;134:39-51 pubmed publisher
    ..In 4-day-old embryos, catalase-containing peroxisomes were obvious in the liver, the pronephric duct and the wall of the yolk sac, but ..
  10. Fitzgerald J, Jameson H, Fowler V, Bond G, Bickley L, Webster T, et al. Hypoxia Suppressed Copper Toxicity during Early Development in Zebrafish Embryos in a Process Mediated by the Activation of the HIF Signaling Pathway. Environ Sci Technol. 2016;50:4502-12 pubmed publisher
    ..These findings change our understanding of the current and future impacts of worldwide oxygen depletion on fish communities challenged by anthropogenic toxicants. ..
  11. Liu H, Sheng N, Zhang W, Dai J. Toxic effects of perfluorononanoic acid on the development of Zebrafish (Danio rerio) embryos. J Environ Sci (China). 2015;32:26-34 pubmed publisher
    ..However, the mRNA expression levels of both ppara and pparg did not show any significant variation after exposure. These findings suggest that PFNA affected the development of zebrafish embryos at relatively low concentrations. ..
  12. Guan B, Ma H, Wang Y, Hu Y, Lin Z, Zhu Z, et al. Vitreoscilla hemoglobin (VHb) overexpression increases hypoxia tolerance in zebrafish (Danio rerio). Mar Biotechnol (NY). 2011;13:336-44 pubmed publisher
    ..alpha 1, heat shock cognate 70-kDa protein, erythropoietin, beta and alpha globin genes, lactate dehydrogenase, catalase, superoxide dismutase, and glutathione peroxidase) of transgenic fish and siblings after hypoxia exposure for 156..
  13. Brun N, Lenz M, Wehrli B, Fent K. Comparative effects of zinc oxide nanoparticles and dissolved zinc on zebrafish embryos and eleuthero-embryos: importance of zinc ions. Sci Total Environ. 2014;476-477:657-66 pubmed publisher
    ..Transcripts of oxidative stress related genes cat and Cu/Zn sod were also altered...
  14. Mukaigasa K, Nguyen L, Li L, Nakajima H, Yamamoto M, Kobayashi M. Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress. Mol Cell Biol. 2012;32:4455-61 pubmed publisher
  15. Mu X, Chai T, Wang K, Zhang J, Zhu L, Li X, et al. Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages. Aquat Toxicol. 2015;160:57-68 pubmed publisher
    ..At 8 dpe, the modification in the transcription of the tested genes in the embryos and adult fish was similar, except for the genes related to the synthesis of sterols. ..
  16. Yuan S, Xu H, Liu L, Zheng J. Different effects of blue and red light-emitting diodes on antioxidant responses in the liver and ovary of zebrafish Danio rerio. Fish Physiol Biochem. 2017;43:411-419 pubmed publisher
    ..damage by LDB could be attributed to the up-regulated levels of mRNA, protein, and activity of Cu/Zn-SOD and CAT. A failure to activate the activity of both enzymes may result in the enhanced PC levels under LDR condition, ..
  17. Lyche J, Nourizadeh Lillabadi R, Karlsson C, Stavik B, Berg V, Skåre J, et al. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Aquat Toxicol. 2011;102:197-204 pubmed publisher
  18. Cunha V, Rodrigues P, Santos M, Moradas Ferreira P, Ferreira M. Danio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development. Aquat Toxicol. 2016;178:182-9 pubmed publisher
    ..e., abcb4, abcc1, abcc2, abcg2, cyp1a, cyp3a65, gst, sod, cat, ahr, pxr, ppar?, ppar?, ppar?, rxraa, rxrab, rxrbb, rxrga, rxrgb, raraa, rarab, rarga evaluated...
  19. Sarkar S, Mukherjee S, Chattopadhyay A, Bhattacharya S. Differential modulation of cellular antioxidant status in zebrafish liver and kidney exposed to low dose arsenic trioxide. Ecotoxicol Environ Saf. 2017;135:173-182 pubmed publisher
    ..Significant increase in GPx and CAT activities in liver and kidney confirmed oxidative stress in zebrafish which correlated with mRNA expression of ..
  20. Moussavi Nik S, Wilson L, Newman M, Croft K, Mori T, Musgrave I, et al. The BACE1-PSEN-A?PP regulatory axis has an ancient role in response to low oxygen/oxidative stress. J Alzheimers Dis. 2012;28:515-30 pubmed publisher
    ..Hypoxia increases catalase gene mRNA indicating increased oxidative stress but we did not observe increased levels of F2-isoprostanes that ..
  21. Zhao X, Ren X, Zhu R, Luo Z, Ren B. Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria-mediated apoptosis in zebrafish embryos. Aquat Toxicol. 2016;180:56-70 pubmed publisher
    ..increased lipid peroxidation, and by increased expression of genes related to the antioxidant defense system (sod1, cat, gpx1a, and ppar?), which were altered at different degrees...
  22. Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
    ..These findings agree with the role of globins in oxidative energy metabolism, but may also hint at a specific function in antioxidative defense. ..
  23. Seo S, Dananjaya S, Nikapitiya C, Park B, Gooneratne R, Kim T, et al. Silver nanoparticles enhance wound healing in zebrafish (Danio rerio). Fish Shellfish Immunol. 2017;68:536-545 pubmed publisher
    ..and -13, pro-inflammatory cytokines (IL-1β and TNF-α) and antioxidant enzymes (superoxide dismutase and catalase), which observed differentiation at 12 and 24 h against the control; but the results were not consistently ..
  24. Randazzo B, Chemello G, Tortarolo I, Chiarello G, Zalas M, Santini A, et al. A Novel Photocatalytic Purification System for Fish Culture. Zebrafish. 2017;14:411-421 pubmed publisher
    ..No significant biological alterations were detectable on the cultured fish. ..
  25. Parolini M, Ghilardi A, Della Torre C, Magni S, Prosperi L, Calvagno M, et al. Environmental concentrations of cocaine and its main metabolites modulated antioxidant response and caused cyto-genotoxic effects in zebrafish embryo cells. Environ Pollut. 2017;226:504-514 pubmed publisher
    ..the mechanism of action (MoA) of all tested drugs was assessed by measuring the activity of defense enzymes (SOD, CAT, GPx, and GST) and the expression of their encoding genes...
  26. Jeon H, Lee Y, Kim M, Choi S, Park B, Lee S. Integrated biomarkers induced by chlorpyrifos in two different life stages of zebrafish (Danio rerio) for environmental risk assessment. Environ Toxicol Pharmacol. 2016;43:166-74 pubmed publisher
    ..Finally, the expression level of acetylcholinesterase (AChE) and catalase (CAT) decreased, whereas that of superoxide dismutase (SOD) did not differ significantly...
  27. Christen V, Faltermann S, Brun N, Kunz P, Fent K. Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in vitro and in zebrafish eleuthero-embryos. Sci Total Environ. 2017;586:1204-1218 pubmed publisher
    ..Barquat and BAC let to induction of ER stress and inflammation in vitro, and BAC and glutaraldehyde at non-toxic concentrations in vivo, while benzalkonium chloride induced expression of tnf-? only. ..
  28. Song Y, Wu B, Chiu C, Chen C, Zhou J, Liang S, et al. Coral-Derived Natural Marine Compound GB9 Impairs Vascular Development in Zebrafish. Int J Mol Sci. 2017;18: pubmed publisher
    ..Moreover, exogenous N-acetyl-cysteine (NAC) treatment rescued the vascular defects in GB9 treated embryos. Our results showed that GB9 exposure causes vascular defects likely mediated by the imbalance of redox homeostasis. ..
  29. Mu X, Chai T, Wang K, Zhu L, Huang Y, Shen G, et al. The developmental effect of difenoconazole on zebrafish embryos: A mechanism research. Environ Pollut. 2016;212:18-26 pubmed publisher
    ..Genes related to hatching, retinoic acid metabolism and lipid homeostasis were up-regulated by difenoconazole. ..
  30. Chen Q, Sun Y, Liu Z, Li Y. Sex-dependent effects of subacute mercuric chloride exposure on histology, antioxidant status and immune-related gene expression in the liver of adult zebrafish (Danio rerio). Chemosphere. 2017;188:1-9 pubmed publisher
    ..In females, Hg2+ exposure decreased CAT activity and its mRNA levels, while increased GSH content and the expressions of sod1, gpx1a, gstr and keap1...
  31. Zhu L, Mu X, Wang K, Chai T, Yang Y, Qiu L, et al. Cyhalofop-butyl has the potential to induce developmental toxicity, oxidative stress and apoptosis in early life stage of zebrafish (Danio rerio). Environ Pollut. 2015;203:40-9 pubmed publisher
    ..Therefore, we speculated that oxidative stress-induced apoptosis should be responsible for abnormal development during embryogenesis after cyhalofop-butyl exposure. ..
  32. Tseng Y, Chen R, Lucassen M, Schmidt M, Dringen R, Abele D, et al. Exploring uncoupling proteins and antioxidant mechanisms under acute cold exposure in brains of fish. PLoS ONE. 2011;6:e18180 pubmed publisher
    ..In addition, the specific activity of superoxide dismutase (SOD) and the mRNA level of catalase (CAT) were increased after cold exposure by about 60% (6 h) and by 60%-90% (1 and 24 h), respectively, while the ..
  33. Faltermann S, Hutter S, Christen V, Hettich T, Fent K. Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio). Toxins (Basel). 2016;8: pubmed publisher
    ..The data further demonstrate that pathways that are influenced by microcystin-LR are not affected by aeruginosin 828A. ..
  34. Si J, Zhang H, Wang Z, Wu Z, Lu J, Di C, et al. Effects of (12)C(6+) ion radiation and ferulic acid on the zebrafish (Danio rerio) embryonic oxidative stress response and gene expression. Mutat Res. 2013;745-746:26-33 pubmed publisher
    ..MDA) content, decreased glutathione (GSH) content and alterations in antioxidant enzyme activities (such as catalase [CAT] and superoxide dismutase [SOD])...
  35. Mukhopadhyay D, Chattopadhyay A. Induction of oxidative stress and related transcriptional effects of sodium fluoride in female zebrafish liver. Bull Environ Contam Toxicol. 2014;93:64-70 pubmed publisher
    ..Antioxidant enzyme (GST, CAT, SOD) activities in the liver altered significantly; the mRNA levels for the genes encoding antioxidant proteins, ..
  36. da Rosa C, Figueiredo M, Lanes C, Almeida D, Marins L. Genotype-dependent gene expression profile of the antioxidant defense system (ADS) in the liver of a GH-transgenic zebrafish model. Transgenic Res. 2011;20:85-9 pubmed publisher
    ..The expression of the Cu, Zn-superoxide dismutase (SOD1) and catalase (CAT) genes was reduced in HO and HE groups, respectively...
  37. Chai T, Cui F, Mu X, Yang Y, Wang C, Qiu J. Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels. PLoS ONE. 2016;11:e0155263 pubmed publisher
    ..Thus, the information in our study could provide new insights to assess the environmental risk of chiral PCBs in aquatic systems. ..
  38. Nathiga Nambi K, Abdul Majeed S, Taju G, Sivasubbu S, Sarath Babu V, Sahul Hameed A. Effects of nicotine on zebrafish: A comparative response between a newly established gill cell line and whole gills. Comp Biochem Physiol C Toxicol Pharmacol. 2017;195:68-77 pubmed publisher
    ..of lipid peroxidation (LPO) while depletion of reduced glutathione (GSH), manganese superoxide dismutase (MnSOD), catalase (CAT), glutathione S-transferase (GST) and glutathione peroxidise(GPx1a) was observed...
  39. Mukhopadhyay D, Priya P, Chattopadhyay A. Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1. Environ Toxicol Pharmacol. 2015;40:352-9 pubmed publisher
    ..Levels of glutathione-s-transferase (GST), catalase (CAT) and superoxide dismutase were also elevated in the treatment groups...
  40. Safari R, Hoseinifar S, Kavandi M. Modulation of antioxidant defense and immune response in zebra fish (Danio rerio) using dietary sodium propionate. Fish Physiol Biochem. 2016;42:1733-1739 pubmed
    ..At the end of the feeding trial, mucosal immune parameters (TNF-?, IL-1?, Lyz), antioxidant enzyme (SOD, CAT) as well as heat shock protein 70 (HSP70) gene expression were measured...
  41. Jin Y, Liu Z, Peng T, Fu Z. The toxicity of chlorpyrifos on the early life stage of zebrafish: a survey on the endpoints at development, locomotor behavior, oxidative stress and immunotoxicity. Fish Shellfish Immunol. 2015;43:405-14 pubmed publisher
    ..CPF affected not only the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione S-transferase (GST), but also the transcriptional levels of ..
  42. Lobo G, Isken A, Hoff S, Babino D, von Lintig J. BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway. Development. 2012;139:2966-77 pubmed publisher
    ..Thus, our study identifying BCDO2 as a crucial protective component against oxidative stress establishes this enzyme as mitochondrial carotenoid scavenger and a gatekeeper of the intrinsic apoptotic pathway. ..
  43. Brun N, Wehrli B, Fent K. Ecotoxicological assessment of solar cell leachates: Copper indium gallium selenide (CIGS) cells show higher activity than organic photovoltaic (OPV) cells. Sci Total Environ. 2016;543:703-14 pubmed publisher
    ..on model water and solar cell, transcriptional alterations occurred in genes involved in oxidative stress (cat), hormonal activity (vtg1, ar), metallothionein (mt2), ER stress (bip, chop), and apoptosis (casp9)...
  44. Hagenaars A, Vergauwen L, Benoot D, Laukens K, Knapen D. Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity. Chemosphere. 2013;91:844-56 pubmed publisher
    ..Despite this increase in metabolic expenditure, no effects on reproduction were found indicating that the fish seemed to cope with exposure to the tested concentrations of PFOA during the exposure period of 1 month. ..
  45. Han P, Zhou X, Chang N, Xiao C, Yan S, Ren H, et al. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Res. 2014;24:1091-107 pubmed publisher
    ..Decreasing H2O2 formation with the Duox inhibitors diphenyleneiodonium (DPI) or apocynin, or scavenging H2O2 by catalase overexpression markedly impaired cardiac regeneration while exogenous H2O2 rescued the inhibitory effects of DPI ..
  46. Lerebours A, Gonzalez P, Adam C, Camilleri V, Bourdineaud J, Garnier Laplace J. Comparative analysis of gene expression in brain, liver, skeletal muscles, and gills of zebrafish (Danio rerio) exposed to environmentally relevant waterborne uranium concentrations. Environ Toxicol Chem. 2009;28:1271-8 pubmed publisher
    ..In skeletal muscles, coxI, atp5f1, and cat were induced at day 3, suggesting an impact on the mitochondrial metabolism and production of reactive oxygen ..
  47. Craig P, Wood C, McClelland G. Oxidative stress response and gene expression with acute copper exposure in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2007;293:R1882-92 pubmed
    ..exposure resulted in significant increases in gene expression of cytochrome c oxidase subunit 17 (COX-17) and catalase, associated with both increased Cu load and protein carbonyl concentrations in the gill and liver after 48 h...
  48. Yuan S, Lv Z, Zhu A, Zheng J, Wu C. Negative effect of chronic cadmium exposure on growth, histology, ultrastructure, antioxidant and innate immune responses in the liver of zebrafish: Preventive role of blue light emitting diodes. Ecotoxicol Environ Saf. 2017;139:18-26 pubmed publisher
    ..Finally, for the first time, our data demonstrated that LDB could protect fish against Cd toxicity. ..
  49. Zhang Q, Li Y, Liu Z, Chen Q. Exposure to mercuric chloride induces developmental damage, oxidative stress and immunotoxicity in zebrafish embryos-larvae. Aquat Toxicol. 2016;181:76-85 pubmed publisher
    ..exposure (especially in the 16?g/L Hg2+ group) induced oxidative stress affecting antioxidant enzyme (CAT, GST and GPX) activities, endogenous GSH and MDA contents, as well as the mRNA levels of genes (cat1, sod1, gstr, ..
  50. Hrubik J, Glisic B, Samardzija D, Stanic B, Pogrmic Majkic K, Fa S, et al. Effect of PMA-induced protein kinase C activation on development and apoptosis in early zebrafish embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2016;190:24-31 pubmed publisher
    ..PMA caused oxidative stress in the embryos as demonstrated by decreased mRNA expression of catalase and superoxide dismutase 2...
  51. Rodríguez Fuentes G, Rubio Escalante F, Noreña Barroso E, Escalante Herrera K, Schlenk D. Impacts of oxidative stress on acetylcholinesterase transcription, and activity in embryos of zebrafish (Danio rerio) following Chlorpyrifos exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2015;172-173:19-25 pubmed publisher
    ..These results give additional evidence to support the role of prooxidants in AChE activity and expression. ..
  52. Zheng J, Yuan S, Wu C, Lv Z. Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio). Aquat Toxicol. 2016;180:36-44 pubmed publisher
    ..The increase may result from the disturbance of genes including copper and zinc superoxide dismutase (Cu/Zn-SOD), catalase (CAT), inducible nitric oxide synthase (iNOS), and ciclooxigenase-2 (COX-2) at mRNA, protein and activity levels...
  53. Lyche J, Nourizadeh Lillabadi R, Almaas C, Stavik B, Berg V, Skåre J, et al. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. J Toxicol Environ Health A. 2010;73:1032-57 pubmed publisher
    ..The effects observed in the experimental zebrafish model raise the question whether chemical pollution represents a risk to reproductive health of wild fish inhabitating the freshwater system. ..
  54. Priyadarshini M, Tuimala J, Chen Y, Panula P. A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling. Neurobiol Dis. 2013;54:127-38 pubmed publisher
    ..Furthermore, we verified that potentially important genes such as hif1?, catalase, SOD3, and atp1a2a were downregulated in pink1 morphants, whereas genes such as fech, pax2a, and notch1a were ..
  55. Zheng J, Yuan S, Wu C, Li W. Chronic waterborne zinc and cadmium exposures induced different responses towards oxidative stress in the liver of zebrafish. Aquat Toxicol. 2016;177:261-8 pubmed publisher
    ..The reduced activity of Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and catalase (CAT) may result in the enhanced hepatic oxidative damage, though the mRNA and protein levels of both genes ..
  56. Stancová V, Ziková A, Svobodová Z, Kloas W. Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2015;40:343-8 pubmed publisher
    ..The mRNA level for the antioxidant enzyme CAT was up-regulated significantly at both the concentrations used...
  57. Sarkar S, Mukherjee S, Chattopadhyay A, Bhattacharya S. Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: expression of antioxidant genes. Ecotoxicol Environ Saf. 2014;107:1-8 pubmed publisher
    ..brain due to As2O3 exposure was further evidenced by significant alteration of glutathione peroxidase (GPx) and catalase (CAT) activity, which converts H2O2 to water and helps in detoxication...
  58. Kishi S, Bayliss P, Uchiyama J, Koshimizu E, Qi J, Nanjappa P, et al. The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet. 2008;4:e1000152 pubmed publisher
    ..Our current strategy of mutant screening for a senescence-associated biomarker in zebrafish embryos may thus prove to be a useful new tool for the genetic dissection of vertebrate stress response and senescence mechanisms. ..
  59. Brun N, Christen V, Furrer G, Fent K. Indium and indium tin oxide induce endoplasmic reticulum stress and oxidative stress in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:11679-87 pubmed publisher
    ..Our study provides first evidence of ER stress and oxidative stress induction by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation. ..
  60. Jin Y, Zhang X, Shu L, Chen L, Sun L, Qian H, et al. Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere. 2010;78:846-52 pubmed publisher
    ..Antioxidant enzyme activities (SOD and CAT), in addition to the GSH and MDA content, in the liver altered significantly; the mRNA levels for the genes ..
  61. Skjærven K, Jakt L, Dahl J, Espe M, Aanes H, Hamre K, et al. Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes. Sci Rep. 2016;6:34535 pubmed publisher
    ..This emphasises the importance of parental micronutrient status for the health of the offspring. ..
  62. Fent K, Chew G, Li J, Gomez E. Benzotriazole UV-stabilizers and benzotriazole: Antiandrogenic activity in vitro and activation of aryl hydrocarbon receptor pathway in zebrafish eleuthero-embryos. Sci Total Environ. 2014;482-483:125-36 pubmed publisher
    ..Forthcoming studies should show whether the observed antiandrogenic activities and transcriptional changes translate into physiological effects . ..
  63. Wang Y, Wu S, Chen J, Zhang C, Xu Z, Li G, et al. Single and joint toxicity assessment of four currently used pesticides to zebrafish (Danio rerio) using traditional and molecular endpoints. Chemosphere. 2018;192:14-23 pubmed publisher
    ..Taken together, increased toxicity might be triggered by the simultaneous presence of several pesticides in the aquatic environment, which seriously damaged the non-target organisms...
  64. Kim S, Ji K, Lee S, Lee J, Kim J, Kim S, et al. Perfluorooctane sulfonic acid exposure increases cadmium toxicity in early life stage of zebrafish, Danio rerio. Environ Toxicol Chem. 2011;30:870-7 pubmed publisher
  65. Cunha V, Santos M, Moradas Ferreira P, Ferreira M. Simvastatin effects on detoxification mechanisms in Danio rerio embryos. Environ Sci Pollut Res Int. 2016;23:10615-29 pubmed publisher
    ..mRNA expression levels of abcb4, abcc1, abcc2, abcg2, cyp1a, cyp3a65, gst, sod, cat was evaluated...
  66. Wan G, Chan K. A study of somatolactin actions by ectopic expression in transgenic zebrafish larvae. J Mol Endocrinol. 2010;45:301-15 pubmed publisher
    ..element binding protein 1, and fatty acid synthase, as well as the expression level of vitellogenin and proopiomelanocortin, while causing reduced levels of catalase and glutathione S-transferase in the larvae of transgenic zebrafish.
  67. Dale K, Rasinger J, Thorstensen K, Penglase S, Ellingsen S. Vitamin E reduces endosulfan-induced toxic effects on morphology and behavior in early development of zebrafish (Danio rerio). Food Chem Toxicol. 2017;101:84-93 pubmed publisher
    ..Elevated ESF concentrations caused down-regulation of the antioxidant genes cuzn-sod, gpx1a and cat, suggesting that ESF promoted oxidative stress in the embryos...
  68. Du J, Cai J, Wang S, You H. Oxidative stress and apotosis to zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonate (PFOS) and ZnO nanoparticles. Int J Occup Med Environ Health. 2017;30:213-229 pubmed publisher
    ..8+25 and 1.6+50 mg/l) mixture solutions until 96 h post-fertilization. Activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx) and malondialdehyde (MDA) content were measured in zebrafish embryos after ..
  69. Jin Y, Liu Z, Liu F, Ye Y, Peng T, Fu Z. Embryonic exposure to cadmium (II) and chromium (VI) induce behavioral alterations, oxidative stress and immunotoxicity in zebrafish (Danio rerio). Neurotoxicol Teratol. 2015;48:9-17 pubmed publisher
    ..Our results suggested that Cd and Cr have the potential to cause behavior alterations, oxidative stress and immunotoxicity in the larval zebrafish. ..
  70. Sun L, Xin L, Peng Z, Jin R, Jin Y, Qian H, et al. Toxicity and enantiospecific differences of two ?-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio). Environ Toxicol. 2014;29:1367-78 pubmed publisher
    ..These results also demonstrated that the enantiospecific toxicity of chiral ?-blockers should be investigated when performing an ecological risk assessment. ..
  71. Chai T, Cui F, Mu X, Yang Y, Qi S, Zhu L, et al. Stereoselective induction by 2,2',3,4',6-pentachlorobiphenyl in adult zebrafish (Danio rerio): Implication of chirality in oxidative stress and bioaccumulation. Environ Pollut. 2016;215:66-76 pubmed publisher
    ..Our findings might be helpful for elucidating the environmental risk of the two enantiomers of PCB91 that induce toxicity in aquatic organisms. ..
  72. Yang Y, Liu W, Mu X, Qi S, Fu B, Wang C. Biological response of zebrafish embryos after short-term exposure to thifluzamide. Sci Rep. 2016;6:38485 pubmed publisher
    ..we quantitatively evaluated the enzyme activities [succinate dehydrogenase (SDH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), caspases], the contents of malonaldehyde (MDA) and interleukin-8 (IL-8) and ..
  73. Choi J, Kim S, Ahn J, Youn P, Kang J, Park K, et al. Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish. Aquat Toxicol. 2010;100:151-9 pubmed publisher
    ..The mRNA levels of the oxyradical-scavenging enzymes catalase and glutathione peroxidase 1a were reduced in the tissues...
  74. Hirayama J, Cho S, Sassone Corsi P. Circadian control by the reduction/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish. Proc Natl Acad Sci U S A. 2007;104:15747-52 pubmed
    ..b>Catalase (Cat), an antioxidant enzyme degrading H(2)O(2), shows an oscillating pattern of expression and activity, ..
  75. De Wit M, Keil D, van der Ven K, Vandamme S, Witters E, De Coen W. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). Gen Comp Endocrinol. 2010;167:190-201 pubmed publisher
    ..Overall, this study demonstrated that a proteomics approach can lift the biological interpretation of microarrays to a higher level, and moreover, opens a window for identification of possible new biomarkers. ..
  76. Hou J, Li L, Xue T, Long M, Su Y, Wu N. Hepatic positive and negative antioxidant responses in zebrafish after intraperitoneal administration of toxic microcystin-LR. Chemosphere. 2015;120:729-36 pubmed publisher
    ..antioxidation and detoxification, the activities and transcriptional levels of antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferases (GST), and ..
  77. Safari R, Hoseinifar S, Van Doan H, Dadar M. The effects of dietary Myrtle (Myrtus communis) on skin mucus immune parameters and mRNA levels of growth, antioxidant and immune related genes in zebrafish (Danio rerio). Fish Shellfish Immunol. 2017;66:264-269 pubmed publisher
    ..Furthermore, fish fed 20 g kg-1 showed remarkably higher antioxidant (sod and cat) enzymes gene expression compared other treatment...
  78. Faltermann S, Grundler V, Gademann K, Pernthaler J, Fent K. Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress. Aquat Toxicol. 2016;171:77-87 pubmed publisher
    ..This is probably due to action to specific organs such as liver and kidneys that could not be identified by whole-embryo sampling. ..