Gene Symbol: casr
Description: calcium-sensing receptor
Alias: casrl, extracellular calcium-sensing receptor, zmp:0000001046
Species: zebrafish

Top Publications

  1. Lin C, Su C, Hwang P. Calcium-sensing receptor mediates Ca(2+) homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology. 2014;155:56-67 pubmed publisher
    ..of the synthesis and/or secretion of hypocalcemic and hypercalcemic hormones by the calcium-sensing receptor (CaSR) is believed to be a major pathway for maintaining Ca(2+) homeostasis in vertebrates, based primarily on findings ..
  2. Lin C, Hu H, Hwang P. Molecular Physiology of the Hypocalcemic Action of Fibroblast Growth Factor 23 in Zebrafish (Danio rerio). Endocrinology. 2017;158:1347-1358 pubmed publisher
    ..Calcium-sensing receptor (CaSR), which senses changes in extracellular Ca2+ levels and modulates calciotropic hormones in organs controlling Ca2+ ..
  3. Pillar N, Pleniceanu O, Fang M, Ziv L, Lahav E, Botchan S, et al. A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Hum Genet. 2017;136:835-845 pubmed publisher an extremely rare disorder, which to date has been linked to several loci including mutations in CASR, GCM2, and PTH, as well as a rare condition defined as X-linked recessive hypoparathyroidism, previously associated ..
  4. Okabe M, Graham A. The origin of the parathyroid gland. Proc Natl Acad Sci U S A. 2004;101:17716-9 pubmed publisher
  5. Dai W, Bai Y, Hebda L, Zhong X, Liu J, Kao J, et al. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ. 2014;21:568-81 pubmed publisher
    ..These results uncover a novel and evolutionarily conserved signaling mechanism that contributes to the abnormal epithelial proliferation associated with Ca(2+) deficiency. ..
  6. Kwong R, Auprix D, Perry S. Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium. Am J Physiol Regul Integr Comp Physiol. 2014;306:R211-21 pubmed publisher
    The involvement of the calcium-sensing receptor (CaSR) in Ca(2+) homeostasis was investigated in larval zebrafish, Danio rerio...
  7. Kumai Y, Kwong R, Perry S. A role for transcription factor glial cell missing 2 in Ca2+ homeostasis in zebrafish, Danio rerio. Pflugers Arch. 2015;467:753-65 pubmed publisher
    ..Overexpression of gcm2 mRNA resulted in a significant increase in the numbers of ecac-expressing ionocytes and Ca(2+) uptake. These observations reveal a critical role for gcm2 in Ca(2+) homeostasis in zebrafish larvae. ..
  8. Bjarnadóttir T, Fredriksson R, Schioth H. The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene. 2005;362:70-84 pubmed
    ..GPCRs form four main phylogenetic groups with a total of eight subgroups (Group I: V2R, TAS1R, GPRC6A, and CASR, Group II: GRM, Group III: GABA together with previously unpublished GPR158 and GPR158L and Group IV: GPRC5)...
  9. Alioto T, Ngai J. The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids. BMC Genomics. 2006;7:309 pubmed

More Information


  1. Herberger A, Loretz C. Morpholino oligonucleotide knockdown of the extracellular calcium-sensing receptor impairs early skeletal development in zebrafish. Comp Biochem Physiol A Mol Integr Physiol. 2013;166:470-81 pubmed publisher
    ..The extracellular calcium-sensing receptor (CaSR) is linked to homeostatic regulation of calcium through its expression in endocrine glands that secrete calcium ..