Gene Symbol: casp6
Description: caspase 6, apoptosis-related cysteine peptidase
Alias: zgc:112960, caspase-6, caspase 6, apoptosis-related cysteine protease, caspase-6a
Inohara N, Nunez G. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ. 2000;7:509-10 pubmed
Sanden M, Jørgensen S, Hemre G, Ørnsrud R, Sissener N. Zebrafish (Danio rerio) as a model for investigating dietary toxic effects of deoxynivalenol contamination in aquaculture feeds. Food Chem Toxicol. 2012;50:4441-8 pubmed publisher
..We do not know if effects observed on fecundity and larvae swimming activity are attributed to a direct interaction of DON with the reproductive organ or secondary to the maternal/paternal liver oxidative imbalance. ..
Felix L, Serafim C, Valentim A, Antunes L, Matos M, Coimbra A. Apoptosis-related genes induced in response to ketamine during early life stages of zebrafish. Toxicol Lett. 2017;279:1-8 pubmed publisher
..Thus, ketamine teratogenicity seems to be dependent on the functional mechanisms present in each developmental stage. ..
Lin H, Lee S, Wu J, Duann Y, Chen J. Development of Cre-loxP technology in zebrafish to study the regulation of fish reproduction. Fish Physiol Biochem. 2013;39:1525-39 pubmed publisher
..Accordingly, this transgenic zebrafish model system provides a method to produce infertile fish and may be useful for application to genetically modified fish...
Sanden M, Ornsrud R, Sissener N, Jorgensen S, Gu J, Bakke A, et al
. Cross-generational feeding of Bt (Bacillus thuringiensis)-maize to zebrafish (Danio rerio) showed no adverse effects on the parental or offspring generations. Br J Nutr. 2013;110:2222-33 pubmed publisher
..Liver gene transcript levels of caspase 6 were significantly lower for the nBt-nBt group than for the Bt-Bt group...
Zhang Q, Cheng J, Xin Q. Effects of tetracycline on developmental toxicity and molecular responses in zebrafish (Danio rerio) embryos. Ecotoxicology. 2015;24:707-19 pubmed publisher
..The overall results indicate that tetracycline can produce oxidative stress and induce apoptosis, which brings about significant developmental delay in zebrafish embryos. ..
Luzio A, Matos M, Santos D, Fontaínhas Fernandes A, Monteiro S, Coimbra A. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17?-ethinylestradiol and fadrozole exposures. Aquat Toxicol. 2016;177:269-84 pubmed publisher
..Overall, our findings show that apoptosis pathways are involved in zebrafish gonad differentiation and that EDCs can disrupt this process. ..
Zhao J, Huang G, Xu T, Yin D, Bai J, Gu W. Early developmental exposure to pentachlorophenol causes alterations on mRNA expressions of caspase protease family in zebrafish embryos. Chemosphere. 2017;180:141-148 pubmed publisher
..Our results suggested that PCP had different effects on varied caspase genes, which probably resulting in a profound impact on caspase proteins and apoptosis processes and, ultimately, developmental abnormality. ..