Gene Symbol: casp2
Description: caspase 2, apoptosis-related cysteine peptidase
Alias: caspase-2, caspase 2, apoptosis-related cysteine protease
Inohara N, Nunez G. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ. 2000;7:509-10 pubmed
Sidi S, Sanda T, Kennedy R, Hagen A, Jette C, Hoffmans R, et al
. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell. 2008;133:864-77 pubmed publisher
..The evolutionarily conserved "Chk1-suppressed" pathway defines a novel apoptotic process, whose responsiveness to Chk1 inhibitors and insensitivity to p53 and BCL2 alterations have important implications for cancer therapy. ..
Espín R, Roca F, Candel S, Sepulcre M, González Rosa J, Alcaraz Pérez F, et al
. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech. 2013;6:383-96 pubmed publisher
..We have identified an evolutionarily conserved apoptotic pathway involved in vascular homeostasis that provides new therapeutic targets for the control of inflammation- and tumor-driven angiogenesis. ..
Wu Z, Zhang W, Lu Y, Lu C. Transcriptome profiling of zebrafish infected with Streptococcus suis. Microb Pathog. 2010;48:178-87 pubmed publisher
..The data may provide further validation of this model, which will contribute to understanding of S. suis pathogenic mechanisms. ..
Zhang J, Sun P, Kong T, Yang F, Guan W. Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Aquat Toxicol. 2016;170:208-215 pubmed publisher
..In short, TBT can produce multiple and complex alterations in transcriptional activity of lipid metabolism and cell damage, which provides potential molecular evidence of TBT on hepatic steatosis. ..
Luzio A, Matos M, Santos D, Fontaínhas Fernandes A, Monteiro S, Coimbra A. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17?-ethinylestradiol and fadrozole exposures. Aquat Toxicol. 2016;177:269-84 pubmed publisher
..Overall, our findings show that apoptosis pathways are involved in zebrafish gonad differentiation and that EDCs can disrupt this process. ..
Zhao J, Huang G, Xu T, Yin D, Bai J, Gu W. Early developmental exposure to pentachlorophenol causes alterations on mRNA expressions of caspase protease family in zebrafish embryos. Chemosphere. 2017;180:141-148 pubmed publisher
..Our results suggested that PCP had different effects on varied caspase genes, which probably resulting in a profound impact on caspase proteins and apoptosis processes and, ultimately, developmental abnormality. ..