Gene Symbol: calb2b
Description: calbindin 2b
Alias: calb2, wu:fq17g09, zgc:73099, calbindin 2, calbindin 2, (calretinin), calretinin
Species: zebrafish
Products:     calb2b

Top Publications

  1. Kapsimali M, Kaushik A, Gibon G, Dirian L, Ernest S, Rosa F. Fgf signaling controls pharyngeal taste bud formation through miR-200 and Delta-Notch activity. Development. 2011;138:3473-84 pubmed publisher
    ..We determine that Fgf activity is required within pharyngeal endoderm for formation of Calb2b(+) cells and reveal miR-200 and Delta-Notch signaling as key factors in this process...
  2. Yin J, Brocher J, Fischer U, Winkler C. Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa. Mol Neurodegener. 2011;6:56 pubmed publisher
    ..Analyzing the AD5 effects in our animal model in vivo, our data imply that aberrant splicing of distinct retinal transcripts contributes to the observed retina defects. ..
  3. Hortopan G, Dinday M, Baraban S. Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish. J Neurosci. 2010;30:13718-28 pubmed publisher
    ..This work may have important implications for neurological and neurodevelopmental disorders associated with mutations in ubiquitin ligase activity. ..
  4. Bernardos R, Lentz S, Wolfe M, Raymond P. Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina. Dev Biol. 2005;278:381-95 pubmed
    ..In contrast to neurons, Müller glia failed to differentiate suggesting an instructive role for Notch-Delta signaling in gliogenesis. ..
  5. Castro A, Becerra M, Manso M, Anadón R. Calretinin immunoreactivity in the brain of the zebrafish, Danio rerio: distribution and comparison with some neuropeptides and neurotransmitter-synthesizing enzymes. I. Olfactory organ and forebrain. J Comp Neurol. 2006;494:435-59 pubmed
    The distribution of calretinin (CR) in the forebrain and the olfactory system of the adult zebrafish was studied by using immunocytochemical techniques...
  6. Volkmann K, Chen Y, Harris M, Wullimann M, Köster R. The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. J Comp Neurol. 2010;518:2794-817 pubmed publisher
  7. Jusuf P, Harris W. Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina. Neural Dev. 2009;4:34 pubmed publisher
    ..This work sets the stage for future studies looking at genetic specification of amacrine subtypes. ..
  8. Mueller T, Guo S. The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. J Comp Neurol. 2009;516:553-68 pubmed publisher
  9. Vitorino M, Jusuf P, Maurus D, Kimura Y, Higashijima S, Harris W. Vsx2 in the zebrafish retina: restricted lineages through derepression. Neural Dev. 2009;4:14 pubmed publisher
    ..Our data thus suggest Vsx2-positive RPCs are fully multipotent retinal progenitors and that when Vsx2 is downregulated, Vsx2-negative progenitors escape Vsx2 repression and so are able to express factors that restrict lineage potential. ..

More Information


  1. Garcia Crespo D, Vecino E. Differential expression of calretinin in the developing and regenerating zebrafish visual system. Histol Histopathol. 2004;19:1193-9 pubmed publisher
    b>Calretinin is a calcium-binding protein which participates in a variety of functions including calcium buffering and neuronal protection. It also serves as a developmental marker of retinal ganglion cells (RGCs)...
  2. Yokoi H, Yan Y, Miller M, Bremiller R, Catchen J, Johnson E, et al. Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Dev Biol. 2009;329:1-15 pubmed publisher
    ..Results identified genes expressed in cartilage (col2a1a and col11a2), retina (calb2a, calb2b, crx, neurod, rs1, sox4a and vsx1) and pectoral fin bud (klf2b and EST AI722369) as candidate targets for Sox9...
  3. Boyer B, Ernest S, Rosa F. Egr-1 induction provides a genetic response to food aversion in zebrafish. Front Behav Neurosci. 2013;7:51 pubmed publisher
    ..Altogether, our data indicate that egr-1 participates specifically in food aversion. The existence of reward-coupled changes in taste sensitivity in humans suggests that our results are relevant to situations in humans. ..
  4. Doi T, Puri P, Bannigan J, Thompson J. Disruption of calreticulin-mediated cellular adhesion signaling in the cadmium-induced omphalocele in the chick model. Pediatr Surg Int. 2010;26:91-5 pubmed publisher
    ..05). There were no significant differences at 8H. Downregulation of CRT, E-cadherin and beta-catenin genes may cause omphalocele in the Cd chick model by disrupting CRT-mediated Ca(2+) signaling and AJs. ..
  5. Duggan C, DeMaria S, Baudhuin A, Stafford D, Ngai J. Foxg1 is required for development of the vertebrate olfactory system. J Neurosci. 2008;28:5229-39 pubmed publisher
    ..Therefore, we identified an evolutionarily conserved requirement for Foxg1 in the development of the vertebrate olfactory system. ..
  6. Hendricks M, Jesuthasan S. Asymmetric innervation of the habenula in zebrafish. J Comp Neurol. 2007;502:611-9 pubmed
    ..Our data establish that there is asymmetric innervation of the habenula from the telencephalon, suggesting a mechanism by which habenula asymmetry might contribute to lateralized behavior. ..
  7. McFarland K, Topczewska J, Weidinger G, Dorsky R, Appel B. Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum. Dev Biol. 2008;318:162-71 pubmed publisher
    ..Specifically, we propose that Hedgehog limits the range of Wnt signaling, which is necessary for olig2(+) neuron development. ..
  8. Bae Y, Kani S, Shimizu T, Tanabe K, Nojima H, Kimura Y, et al. Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Dev Biol. 2009;330:406-26 pubmed publisher
    ..Our data provide a platform for future studies of zebrafish cerebellar development. ..
  9. Bhoyar R, Jadhao A, Sivasubbu S, Singh A, Sabharwal A, Palande N, et al. Neuroanatomical demonstration of calbindin 2a- and calbindin 2b-like calcium binding proteins in the early embryonic development of zebrafish: mRNA study. Int J Dev Neurosci. 2017;60:26-33 pubmed publisher
    ..We have investigated the mRNA expression of CaBPs, calbindin 2a (Calb2a) and calbindin 2b (Calb2b) in the zebrafish embryos 24, 36, 48 and 72h post fertilization (hpf)...
  10. Graña P, Anadón R, Yáñez J. Immunocytochemical study of calretinin and calbindin D-28K expression in the retina of three cartilaginous fishes and a cladistian (Polypterus). Brain Res Bull. 2008;75:375-8 pubmed publisher
    The distribution of two calcium-binding proteins, calbindin D-28K (CB) and calretinin (CR) was studied in the retina of a cladistian, Polypterus senegalus, and three cartilaginous fishes (Scyliorhinus canicula, Raja undulata and Torpedo ..
  11. Levanti M, Montalbano G, Laura R, Ciriaco E, Cobo T, Garcia Suarez O, et al. Calretinin in the peripheral nervous system of the adult zebrafish. J Anat. 2008;212:67-71 pubmed publisher
    b>Calretinin is a calcium-binding protein found widely distributed in the central nervous system and chemosensory cells of the teleosts, but its presence in the peripheral nervous system of fishes is unknown...
  12. Rohrschneider M, Elsen G, Prince V. Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Dev Biol. 2007;309:358-72 pubmed
    ..Using morpholino knock-down and cell transplantation, we demonstrate that the Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity. ..
  13. Gonzalez Nunez V, Nocco V, Budd A. Characterization of drCol 15a1b: a novel component of the stem cell niche in the zebrafish retina. Stem Cells. 2010;28:1399-411 pubmed publisher
  14. Germana A, Paruta S, Germanà G, Ochoa Erena F, Montalbano G, Cobo J, et al. Differential distribution of S100 protein and calretinin in mechanosensory and chemosensory cells of adult zebrafish (Danio rerio). Brain Res. 2007;1162:48-55 pubmed
    ..and Western blot were used to investigate the occurrence and the distribution of S100 protein and calretinin in mechanosensory (neuromasts of the lateral line system; maculae and cristae ampullaris of the inner ear) as ..
  15. Bernardos R, Raymond P. GFAP transgenic zebrafish. Gene Expr Patterns. 2006;6:1007-13 pubmed
    ..GFP expression in glia co-localized with anti-GFAP antibodies, but did not co-localize with the neuronal antibodies HuC/D or calretinin in mature neurons.
  16. Castro A, Becerra M, Manso M, Anadón R. Calretinin immunoreactivity in the brain of the zebrafish, Danio rerio: distribution and comparison with some neuropeptides and neurotransmitter-synthesizing enzymes. II. Midbrain, hindbrain, and rostral spinal cord. J Comp Neurol. 2006;494:792-814 pubmed
    The distribution of calretinin (CR) in the brainstem and rostral spinal cord of the adult zebrafish was studied by using immunocytochemical techniques...
  17. Viloria A, Rodríguez Alonso M, Costas V, Pérez Fernández J, Pombal M, Megias M. Developmental changes of calretinin immunoreactivity in the lamprey spinal cord. Brain Res Bull. 2008;75:428-32 pubmed publisher
    We studied the distribution of calretinin immunoreactivity (CR-ir) in the rostral and intermediate levels of the spinal cord of lampreys from embryonic to adult periods...