Gene Symbol: cahz
Description: carbonic anhydrase
Alias: CAH-Z, cah, cb588, id:ibd5016, wu:cegs2190, wu:fj65c09, carbonic anhydrase, ca2b, carbonate dehydratase, zCA2-like b, zCAb
Species: zebrafish
Products:     cahz

Top Publications

  1. Galloway J, Wingert R, Thisse C, Thisse B, Zon L. Combinatorial regulation of novel erythroid gene expression in zebrafish. Exp Hematol. 2008;36:424-32 pubmed publisher
    ..Additionally, these studies establish that blood gene expression programs are regulated by transcription factors acting in combination during erythroid maturation. ..
  2. Lin T, Liao B, Horng J, Yan J, Hsiao C, Hwang P. Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. Am J Physiol Cell Physiol. 2008;294:C1250-60 pubmed publisher
    ..These results provide molecular physiological evidence to support the roles of these two zCA isoforms in Na+ uptake and acid-base regulation mechanisms in zebrafish HR cells. ..
  3. Gilmour K, Thomas K, Esbaugh A, Perry S. Carbonic anhydrase expression and CO2 excretion during early development in zebrafish Danio rerio. J Exp Biol. 2009;212:3837-45 pubmed publisher
    b>Carbonic anhydrase (CA) is critical for CO2 excretion in adult fish, but little is known of the expression or function of CA during early development...
  4. Kassen S, Ramanan V, Montgomery J, T Burket C, Liu C, Vihtelic T, et al. Time course analysis of gene expression during light-induced photoreceptor cell death and regeneration in albino zebrafish. Dev Neurobiol. 2007;67:1009-31 pubmed
    ..Some of the Stat3-positive Müller cells expressed PCNA at 31 h, suggesting that Stat3 may play a role in signaling a subset of Müller cells to proliferate during the regeneration response. ..
  5. Craig P, Wood C, McClelland G. Gill membrane remodeling with soft-water acclimation in zebrafish (Danio rerio). Physiol Genomics. 2007;30:53-60 pubmed
    ..mRNA expression levels of gill Na(+)-K(+)-ATPase (NKA) alpha1a subunit, epithelium calcium channel (ECaC), carbonic anhydrase-1 and 2 (CA-1, CA-2), Na(+)/H(+) exchanger (NHE-2), V-type proton (H(+))-ATPase, and copper transport ..
  6. Almeida D, De Martinez Gaspar Martins C, de Azevedo Figueiredo M, Lanes C, Bianchini A, Marins L. Growth hormone transgenesis affects osmoregulation and energy metabolism in zebrafish (Danio rerio). Transgenic Res. 2013;22:75-88 pubmed publisher
    ..Genes coding for Na(+), K(+)-ATPase, H(+)-ATPase, plasma carbonic anhydrase and cytosolic carbonic anhydrase were up-regulated in gills of transgenics in freshwater...
  7. Xiong X, Dong C, Xu X, Weng S, Liu Z, He J. Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus. Dev Comp Immunol. 2011;35:431-40 pubmed publisher
    ..These findings provide insight into the interactions between iridoviruses (especially ISKNV) and host, as well as the mechanism and pathogenesis of ISKNV infections. ..
  8. Li W, Zhou L, Li Z, Wang Y, Shi J, Yang Y, et al. Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation. Int J Biol Sci. 2015;11:688-700 pubmed publisher
    ..Furthermore, knockdown of lbh-like increases the activity of Notch pathway and perturbs the balance among proliferation, differentiation and survival of photoreceptor precursors. ..
  9. Tohse H, Murayama E, Ohira T, Takagi Y, Nagasawa H. Localization and diurnal variations of carbonic anhydrase mRNA expression in the inner ear of the rainbow trout Oncorhynchus mykiss. Comp Biochem Physiol B Biochem Mol Biol. 2006;145:257-64 pubmed
    Physiological studies have suggested that carbonic anhydrase (CA) plays a central role in otolith biomineralization via ion transport. However, the presence and exact function of CA in the inner ear have not been determined...

More Information


  1. Agathon A, Thisse C, Thisse B. The molecular nature of the zebrafish tail organizer. Nature. 2003;424:448-52 pubmed
    ..In contrast to induction of the vertebrate head, known to result from the triple inhibition of BMP, Nodal and Wnt, here we show that induction of the tail results from the triple stimulation of BMP, Nodal and Wnt8 signalling pathways. ..
  2. Galloway J, Wingert R, Thisse C, Thisse B, Zon L. Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell. 2005;8:109-16 pubmed
    ..Our studies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstrate that gata1 plays an integral role in directing myelo-erythroid lineage fate decisions during embryogenesis. ..
  3. Ito Y, Kobayashi S, Nakamura N, Miyagi H, Esaki M, Hoshijima K, et al. Close Association of Carbonic Anhydrase (CA2a and CA15a), Na(+)/H(+) Exchanger (Nhe3b), and Ammonia Transporter Rhcg1 in Zebrafish Ionocytes Responsible for Na(+) Uptake. Front Physiol. 2013;4:59 pubmed publisher
    ..mechanism for the Na(+) uptake, we performed a systematic analysis of gene expression patterns of zebrafish carbonic anhydrase (CA) isoforms and found that, of 12 CA isoforms, CA2a and CA15a are highly expressed in H-MRCs at larval ..
  4. Qian F, Zhen F, Ong C, Jin S, Meng Soo H, Stainier D, et al. Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Dev Dyn. 2005;233:1163-72 pubmed
    ..We further determine that of these 13 new targets, 8 genes, including coproporphyrinogen oxidase (cpo), carbonic anhydrase (cahz), claudin g (cldn g), zinc-finger-like gene 2 (znfl2), neutrophil cytosol factor 1 (ncf1), matrix ..
  5. Esbaugh A, Perry S, Gilmour K. Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish, Danio rerio. Am J Physiol Regul Integr Comp Physiol. 2009;296:R150-60 pubmed publisher
    Recent evidence suggests that carbonic anhydrase (CA) IX in humans is under the regulatory control of hypoxia-inducible factor and is overexpressed in certain cancers...
  6. Abbas L, Whitfield T. Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva. Development. 2009;136:2837-48 pubmed publisher
    ..This exemplifies the use of morpholinos as potential therapeutic agents for genetic disease...
  7. Yurco P, Cameron D. Responses of Müller glia to retinal injury in adult zebrafish. Vision Res. 2005;45:991-1002 pubmed
    ..The results suggested a model of retinal regeneration in which lesions are filled, in part, by a localized en place cytogenesis within intact retina surrounding the lesion site. ..
  8. Tarbashevich K, Reichman Fried M, Grimaldi C, Raz E. Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Curr Biol. 2015;25:1096-103 pubmed publisher
    ..Specifically, we show that Carbonic Anhydrase 15b, an enzyme controlling the pH in many cell types, including metastatic cancer cells, is expressed in ..
  9. Matsumoto H, Fujiwara S, Miyagi H, Nakamura N, Shiga Y, Ohta T, et al. Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear. Mar Biotechnol (NY). 2017;19:430-440 pubmed publisher
    ..Thus, our findings demonstrated the importance of potential risk assessment of CA inhibition, especially regarding the formation of otoliths as a one of the most sensitive organs in embryogenesis. ..
  10. Morris A, Scholz T, Brockerhoff S, Fadool J. Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Dev Neurobiol. 2008;68:605-19 pubmed publisher
    ..These two genetic models therefore offer new opportunities for investigating the molecular mechanisms of selective degeneration and regeneration of rods and cones. ..
  11. Catalano A, Raymond P, Goldman D, Wei X. Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina. Dev Dyn. 2007;236:1295-306 pubmed
    ..Identification and further study of the dou yan gene will enhance our understanding of the molecular mechanisms regulating retinal cellular homeostasis, i.e., the balance between cell proliferation and cell death. ..
  12. Morris A, Schroeter E, Bilotta J, Wong R, Fadool J. Cone survival despite rod degeneration in XOPS-mCFP transgenic zebrafish. Invest Ophthalmol Vis Sci. 2005;46:4762-71 pubmed
    ..This raises important questions about the significance of rod-cone interactions in zebrafish and their potential as a model of human inherited retinal degenerations. ..