Gene Symbol: ca2
Description: carbonic anhydrase II
Alias: ca2a, cb1082, wu:fb50f02, wu:fk91a02, carbonic anhydrase II, zCA2-like a
Species: zebrafish

Top Publications

  1. Esaki M, Hoshijima K, Kobayashi S, Fukuda H, Kawakami K, Hirose S. Visualization in zebrafish larvae of Na(+) uptake in mitochondria-rich cells whose differentiation is dependent on foxi3a. Am J Physiol Regul Integr Comp Physiol. 2007;292:R470-80 pubmed
    ..We also utilized a set of ion transport inhibitors to assess the molecules involved in the process and discuss the observations. ..
  2. Yan J, Chou M, Kaneko T, Hwang P. Gene expression of Na+/H+ exchanger in zebrafish H+ -ATPase-rich cells during acclimation to low-Na+ and acidic environments. Am J Physiol Cell Physiol. 2007;293:C1814-23 pubmed
  3. Lin T, Liao B, Horng J, Yan J, Hsiao C, Hwang P. Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. Am J Physiol Cell Physiol. 2008;294:C1250-60 pubmed publisher
    ..These results provide molecular physiological evidence to support the roles of these two zCA isoforms in Na+ uptake and acid-base regulation mechanisms in zebrafish HR cells. ..
  4. Fitzgerald J, Jameson H, Fowler V, Bond G, Bickley L, Webster T, et al. Hypoxia Suppressed Copper Toxicity during Early Development in Zebrafish Embryos in a Process Mediated by the Activation of the HIF Signaling Pathway. Environ Sci Technol. 2016;50:4502-12 pubmed publisher
    ..These findings change our understanding of the current and future impacts of worldwide oxygen depletion on fish communities challenged by anthropogenic toxicants. ..
  5. Sumi K, Kim S, Natarajan S, Choi K, Choi M, Kim H, et al. Molecular cloning and characterization of secretory carbonic anhydrase VI in pufferfish (Takifugu rubripes). Gene. 2018;640:57-65 pubmed publisher
    ..Reverse transcription-polymerase chain reaction (PCR), quantitative PCR and in situ hybridization results revealed that, the pufferfish CA VI is highly expressed in liver tissue...
  6. Perkins B, Nicholas C, Baye L, Link B, Dowling J. dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina. Dev Dyn. 2005;233:680-94 pubmed
    ..Taken together, our studies suggest a role for the dazed gene in rod and Muller cell development and overall retinal cell survival and maintenance. ..
  7. Baker B, Yee J, Meyer D, Yang D, Baker T. Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Zebrafish. 2016;13:413-23 pubmed publisher
    ..These data will inform future investigations to elucidate the mechanism of adult-onset and transgenerational infertility due to TCDD exposure in zebrafish. ..
  8. Lin C, Shih T, Liu S, Hsu H, Hwang P. Cortisol Regulates Acid Secretion of H(+)-ATPase-rich Ionocytes in Zebrafish (Danio rerio) Embryos. Front Physiol. 2015;6:328 pubmed publisher
  9. Tarbashevich K, Reichman Fried M, Grimaldi C, Raz E. Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Curr Biol. 2015;25:1096-103 pubmed publisher

More Information


  1. Rodius S, Nazarov P, Nepomuceno Chamorro I, Jeanty C, González Rosa J, Ibberson M, et al. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. BMC Genomics. 2014;15:852 pubmed publisher
    ..For example, ptgis and ca2 were overexpressed, while usp2a, a regulator of the p53 pathway, was down-regulated in our in vivo models...
  2. Gilmour K, Thomas K, Esbaugh A, Perry S. Carbonic anhydrase expression and CO2 excretion during early development in zebrafish Danio rerio. J Exp Biol. 2009;212:3837-45 pubmed publisher
    ..These results suggest that between 24 h.p.f. and 48 h.p.f., developing zebrafish begin to rely on CA to meet requirements for increased CO2 excretion. ..
  3. Esbaugh A, Perry S, Gilmour K. Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish, Danio rerio. Am J Physiol Regul Integr Comp Physiol. 2009;296:R150-60 pubmed publisher
  4. Christensen A, Jensen A. Tissue-specific requirements for specific domains in the FERM protein Moe/Epb4.1l5 during early zebrafish development. BMC Dev Biol. 2008;8:3 pubmed publisher
    ..1l5long, and suggest that additional C' terminal sequences are important for zebrafish retinal development. Additionally, our data provide further evidence that Moe is a negative regulator of rod outer segment size. ..
  5. Rohrschneider M, Elsen G, Prince V. Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Dev Biol. 2007;309:358-72 pubmed
    ..Using morpholino knock-down and cell transplantation, we demonstrate that the Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity. ..
  6. Ito Y, Kobayashi S, Nakamura N, Miyagi H, Esaki M, Hoshijima K, et al. Close Association of Carbonic Anhydrase (CA2a and CA15a), Na(+)/H(+) Exchanger (Nhe3b), and Ammonia Transporter Rhcg1 in Zebrafish Ionocytes Responsible for Na(+) Uptake. Front Physiol. 2013;4:59 pubmed publisher
    ..of gene expression patterns of zebrafish carbonic anhydrase (CA) isoforms and found that, of 12 CA isoforms, CA2a and CA15a are highly expressed in H-MRCs at larval stages...
  7. Guh Y, Tseng Y, Yang C, Hwang P. Endothelin-1 regulates H?-ATPase-dependent transepithelial H? secretion in zebrafish. Endocrinology. 2014;155:1728-37 pubmed publisher
    ..These findings provide evidence that EDN1 signaling is involved in acid-base regulation in zebrafish and enhance our understanding of EDN1 regulation of transepithelial H? secretion in vertebrates. ..
  8. Miller S, Pollack J, Bradshaw J, Kumai Y, Perry S. Cardiac responses to hypercapnia in larval zebrafish (Danio rerio): the links between CO2 chemoreception, catecholamines and carbonic anhydrase. J Exp Biol. 2014;217:3569-78 pubmed publisher
    ..75% CO2) was reduced in fish at 5 d.p.f. exposed to acetazolamide, a CA inhibitor, and in fish experiencing zCAc (CA2-like a) knockdown...
  9. Kazokaitė J, Aspatwar A, Kairys V, Parkkila S, Matulis D. Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide. Drug Chem Toxicol. 2017;40:309-319 pubmed publisher
    ..Therefore, the exposure to VD11-4-2 and VD12-09 at concentrations below LC50 did not lead to deleterious effects on the zebrafish embryonic development and thus both inhibitors may be further developed as drugs. ..
  10. Hsiao C, You M, Guh Y, Ma M, Jiang Y, Hwang P. A positive regulatory loop between foxi3a and foxi3b is essential for specification and differentiation of zebrafish epidermal ionocytes. PLoS ONE. 2007;2:e302 pubmed
  11. Matsumoto H, Fujiwara S, Miyagi H, Nakamura N, Shiga Y, Ohta T, et al. Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear. Mar Biotechnol (NY). 2017;19:430-440 pubmed publisher
    ..Thus, our findings demonstrated the importance of potential risk assessment of CA inhibition, especially regarding the formation of otoliths as a one of the most sensitive organs in embryogenesis. ..
  12. Craig P, Wood C, McClelland G. Gill membrane remodeling with soft-water acclimation in zebrafish (Danio rerio). Physiol Genomics. 2007;30:53-60 pubmed
    ..This not only enhances our understanding of ionoregulatory processes in fish but also highlights the need for proper experimental design for studies involving preacclimation to soft water (e.g., metal toxicity). ..
  13. Almeida D, De Martinez Gaspar Martins C, de Azevedo Figueiredo M, Lanes C, Bianchini A, Marins L. Growth hormone transgenesis affects osmoregulation and energy metabolism in zebrafish (Danio rerio). Transgenic Res. 2013;22:75-88 pubmed publisher