ca15a

Summary

Gene Symbol: ca15a
Description: carbonic anhydrase XVa
Alias: zgc:158584, carbonic anhydrase XVa, ca4c, carbonic anhydrase IV-like protein, carbonic anhydrase XV a, zCA15a
Species: zebrafish

Top Publications

  1. Yan J, Chou M, Kaneko T, Hwang P. Gene expression of Na+/H+ exchanger in zebrafish H+ -ATPase-rich cells during acclimation to low-Na+ and acidic environments. Am J Physiol Cell Physiol. 2007;293:C1814-23 pubmed
  2. Lin T, Liao B, Horng J, Yan J, Hsiao C, Hwang P. Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells. Am J Physiol Cell Physiol. 2008;294:C1250-60 pubmed publisher
    ..By screening with whole mount in situ hybridization, only zca2-like a and zca15a were found to be expressed in specific groups of cells in zebrafish gills/skin, and further analyses by triple in ..
  3. Lin C, Shih T, Liu S, Hsu H, Hwang P. Cortisol Regulates Acid Secretion of H(+)-ATPase-rich Ionocytes in Zebrafish (Danio rerio) Embryos. Front Physiol. 2015;6:328 pubmed publisher
  4. Nathiga Nambi K, Abdul Majeed S, Taju G, Sivasubbu S, Sarath Babu V, Sahul Hameed A. Effects of nicotine on zebrafish: A comparative response between a newly established gill cell line and whole gills. Comp Biochem Physiol C Toxicol Pharmacol. 2017;195:68-77 pubmed publisher
    ..Collectively, our result suggests that nicotine has the potential to induce reactive oxygen species (ROS) production, oxidative stress and apoptosis in DrG cell line and zebrafish. ..
  5. Matsumoto H, Fujiwara S, Miyagi H, Nakamura N, Shiga Y, Ohta T, et al. Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear. Mar Biotechnol (NY). 2017;19:430-440 pubmed publisher
    ..Thus, our findings demonstrated the importance of potential risk assessment of CA inhibition, especially regarding the formation of otoliths as a one of the most sensitive organs in embryogenesis. ..
  6. Wang Y, Tseng Y, Yan J, Hiroi J, Hwang P. Role of SLC12A10.2, a Na-Cl cotransporter-like protein, in a Cl uptake mechanism in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009;296:R1650-60 pubmed publisher
    ..These results for the first time provide in vivo molecular physiological evidence for the possible role of the NCC in the Cl(-) uptake mechanism in zebrafish skin/gills. ..
  7. Ito Y, Kobayashi S, Nakamura N, Miyagi H, Esaki M, Hoshijima K, et al. Close Association of Carbonic Anhydrase (CA2a and CA15a), Na(+)/H(+) Exchanger (Nhe3b), and Ammonia Transporter Rhcg1 in Zebrafish Ionocytes Responsible for Na(+) Uptake. Front Physiol. 2013;4:59 pubmed publisher
    ..gene expression patterns of zebrafish carbonic anhydrase (CA) isoforms and found that, of 12 CA isoforms, CA2a and CA15a are highly expressed in H-MRCs at larval stages...
  8. Tarbashevich K, Reichman Fried M, Grimaldi C, Raz E. Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Curr Biol. 2015;25:1096-103 pubmed publisher
  9. Guh Y, Tseng Y, Yang C, Hwang P. Endothelin-1 regulates H?-ATPase-dependent transepithelial H? secretion in zebrafish. Endocrinology. 2014;155:1728-37 pubmed publisher
    ..These findings provide evidence that EDN1 signaling is involved in acid-base regulation in zebrafish and enhance our understanding of EDN1 regulation of transepithelial H? secretion in vertebrates. ..

More Information

Publications11

  1. Sumi K, Nou I, Kho K. Identification and expression of a novel carbonic anhydrase isozyme in the pufferfish Takifugu vermicularis. Gene. 2016;588:173-9 pubmed publisher
    ..Our results suggest that the pCAn isozyme might be related to CA IV-like isozymes. Further functional studies are needed to investigate the function of the pCAn isozyme in T. vermicularis. ..
  2. Tseng Y, Chen R, Lee J, Liu S, Lee S, Hwang P. Specific expression and regulation of glucose transporters in zebrafish ionocytes. Am J Physiol Regul Integr Comp Physiol. 2009;297:R275-90 pubmed publisher
    ..Taken together, zGLUT1a, -6, and 13.1, the specific transporters in NaR/NCC cells, GR cells, and HR cells, may absorb glucose into the respective cells to fulfill different physiological demands. ..