Gene Symbol: c3a.3
Description: complement component c3a, duplicate 3
Alias: C3-3, c3-2, c3c, unp301, zgc:103610, complement component c3a, duplicate 3, c3.3, complement component C3-2, complement component c3c
Wang Z, Zhang S, Wang G. Response of complement expression to challenge with lipopolysaccharide in embryos/larvae of zebrafish Danio rerio: acquisition of immunocompetent complement. Fish Shellfish Immunol. 2008;25:264-70 pubmed publisher
..Taken together, these suggest that the complement operating via the AP is already competent by responding to challenge with LPS in the hatched larvae of Danio rerio. ..
Gongora R, Figueroa F, Klein J. Independent duplications of Bf and C3 complement genes in the zebrafish. Scand J Immunol. 1998;48:651-8 pubmed
..Independent duplications of the Bf and C3 genes in bony fishes suggest that complement plays a prominent part in the immune response of this class of vertebrates. ..
Jiang C, Wang P, Li M, Liu S, Zhang S. Dietary ?-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish. Dev Comp Immunol. 2016;65:107-113 pubmed publisher
..Collectively, these data show for the first time that ?-glucan can be safely used to promote the non-specific immunity in offspring of fishes. ..
Huang S, Cheng C, Chen J, Gong H, Liu W, Wu J. Inducible liver-specific overexpression of gankyrin in zebrafish results in spontaneous intrahepatic cholangiocarcinoma and hepatocellular carcinoma formation. Biochem Biophys Res Commun. 2017;490:1052-1058 pubmed publisher
..Herein, we demonstrate an excellent zebrafish model for liver cancers that will be useful for studying the molecular mechanisms of tumorgenesis. ..
Wang C, Chen Y, Bian W, Xie S, Qi G, Liu L, et al
. Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish Shellfish Immunol. 2018;72:572-580 pubmed publisher
..While each paralogue contributes to the response to bacterial insult, mstnb affects the immune system through activation of the NF-?B pathway, and mstna is likely to act upstream of NF-?B at some as yet unidentified target. ..
Lu A, Hu X, Xue J, Zhu J, Wang Y, Zhou G. Gene expression profiling in the skin of zebrafish infected with Citrobacter freundii. Fish Shellfish Immunol. 2012;32:273-83 pubmed publisher
..This is first report that skin play important roles in innate immune responses to bacterial infection, which contribute to understanding the defense mechanisms of the skin in fish. ..
Lu A, Hu X, Wang Y, Shen X, Zhu A, Shen L, et al
. Comparative analysis of the acute response of zebrafish Danio rerio skin to two different bacterial infections. J Aquat Anim Health. 2013;25:243-51 pubmed publisher
..g., ceruloplasmin, alpha-1-microglobulin, vitellogenin, and heat shock protein). These results suggest that the skin of fish plays an important role in the innate immune responses to bacterial infection. ..
Forn Cuni G, Reis E, Dios S, Posada D, Lambris J, Figueras A, et al
. The evolution and appearance of C3 duplications in fish originate an exclusive teleost c3 gene form with anti-inflammatory activity. PLoS ONE. 2014;9:e99673 pubmed publisher
Lima A, Cha B, Amin J, Smith L, Anderson B. Zebrafish embryo model of Bartonella henselae infection. Zebrafish. 2014;11:434-46 pubmed publisher
..Thus, the zebrafish embryo provides the first practical model of Bh infection that will facilitate efforts to identify virulence factors and define molecular mechanisms of Bh pathogenesis. ..